{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:20Z","timestamp":1787022380213,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["G12P6417"],"award-info":[{"award-number":["G12P6417"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The exercise paradox infers that, despite the well\u2010established cardioprotective effects of repeated episodic exercise (training), the risk of acute atherothrombotic events may be transiently increased during and soon after an exercise bout. However, the acute impact of different exercise modalities on platelet function has not previously been addressed. We hypothesized that distinct modalities of exercise would have differing effects on\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    platelet activation and reactivity to agonists which induce monocyte\u2010platelet aggregate (\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    ) formation. Eight middle\u2010aged (53.5\u00a0\u00b1\u00a01.6\u00a0years) male participants took part in four 30\u00a0min experimental interventions (aerobic\n                    <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                    , resistance\n                    <jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>\n                    , combined aerobic\/resistance exercise\n                    <jats:styled-content style=\"fixed-case\">CARE<\/jats:styled-content>\n                    , or no\u2010exercise\n                    <jats:styled-content style=\"fixed-case\">NE<\/jats:styled-content>\n                    ), in random order. Blood samples were collected before, immediately after, and 1\u00a0h after each intervention, and incubated with one of three agonists of physiologically\/clinically relevant pathways of platelet activation (thrombin receptor activating peptide\u20106\n                    <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\n                    , arachidonic acid\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    , and cross\u2010linked collagen\u2010related peptide\n                    <jats:styled-content style=\"fixed-case\">xCRP<\/jats:styled-content>\n                    ). In the presence of\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">xCRP<\/jats:styled-content>\n                    , both\n                    <jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">CARE<\/jats:styled-content>\n                    evoked increases in\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    s immediately post\u2010exercise (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.01), whereas only\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    significantly increased\n                    <jats:styled-content style=\"fixed-case\">MPA<\/jats:styled-content>\n                    s immediately after\n                    <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                    (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.01). These increases in platelet activation post\u2010exercise were transient, as responses approached pre\u2010exercise levels by 1\u00a0h. These are the first data to suggest that exercise involving a resistance component in humans may transiently increase platelet\u2010mediated thrombotic risk more than aerobic modalities.\n                  <\/jats:p>","DOI":"10.14814\/phy2.12951","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T11:48:16Z","timestamp":1476791296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of commonly prescribed exercise interventions on platelet activation in physically inactive and overweight men"],"prefix":"10.14814","volume":"4","author":[{"given":"Andrew","family":"Haynes","sequence":"first","affiliation":[{"name":"School of Sport Science, Exercise and Health University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Linden","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Robey","sequence":"additional","affiliation":[{"name":"School of Sport Science, Exercise and Health University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald F.","family":"Watts","sequence":"additional","affiliation":[{"name":"Cardiometabolic Services Department of Cardiology Royal Perth Hospital Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Barrett","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology Royal Perth Hospital Unit University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise H.","family":"Naylor","sequence":"additional","affiliation":[{"name":"School of Sport Science, Exercise and Health University of Western Australia Crawley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Green","sequence":"additional","affiliation":[{"name":"School of Sport Science, Exercise and Health University of Western Australia Crawley Western Australia Australia"},{"name":"Research Institute for Sport and Exercise Science Liverpool John Moores University Liverpool United Kingdom"},{"name":"Principal Research Fellow National Health and Medical Research Council Canberra ACT Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"(ACSM)ACoSM.2013.ACSM's Guidelines For Exercise Testing And Prescription. 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