{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:57:41Z","timestamp":1776211061757,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305936\/2013-1"],"award-info":[{"award-number":["305936\/2013-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/05629-4"],"award-info":[{"award-number":["2013\/05629-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/18151-7"],"award-info":[{"award-number":["2010\/18151-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/09014-9"],"award-info":[{"award-number":["2011\/09014-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.14814\/phy2.12961","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:48:32Z","timestamp":1474505312000},"page":"e12961","source":"Crossref","is-referenced-by-count":20,"title":["Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats"],"prefix":"10.14814","volume":"4","author":[{"given":"Silvania da Silva","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics; Institute of Biomedical Sciences; University of S\u00e3o Paulo; S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C.","family":"Panveloski-Costa","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics; Institute of Biomedical Sciences; University of S\u00e3o Paulo; S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics; Institute of Biomedical Sciences; University of S\u00e3o Paulo; S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana P.","family":"Monteiro Schiavon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics; State University of Maringa; Maringa Parana Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Any de Castro","family":"Ruiz Marque","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics; State University of Maringa; Maringa Parana Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel S.","family":"Campello","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics; Institute of Biomedical Sciences; University of S\u00e3o Paulo; S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto B.","family":"Bazotte","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics; State University of Maringa; Maringa Parana Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics; Institute of Biomedical Sciences; University of S\u00e3o Paulo; S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"10.14814\/phy2.12961-BIB0001|phy212961-cit-0001","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2826.2009.01932.x","article-title":"Central and peripheral effects of thyroid hormone signalling in the control of energy metabolism","volume":"22","author":"Alkemade","year":"2010","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.14814\/phy2.12961-BIB0002|phy212961-cit-0002","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tem.2005.03.010","article-title":"FoxO proteins in insulin action and metabolism","volume":"16","author":"Barthel","year":"2005","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"10.14814\/phy2.12961-BIB0103|phy212961-cit-0103","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/thy.2010.0409","article-title":"T3 rapidly increases SLC2A4 gene expression and GLUT4 trafficking to the plasma membrane in skeletal muscle of rat and improves glucose homeostasis","volume":"22","author":"Brunetto","year":"2012","journal-title":"Thyroid."},{"key":"10.14814\/phy2.12961-BIB0003|phy212961-cit-0003","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.lfs.2009.02.024","article-title":"Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase","volume":"84","author":"Caton","year":"2009","journal-title":"Life Sci."},{"key":"10.14814\/phy2.12961-BIB0004|phy212961-cit-0004","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrd3180","article-title":"SGLT2 inhibition-a novel strategy for diabetes treatment","volume":"9","author":"Chao","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.14814\/phy2.12961-BIB0005|phy212961-cit-0005","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1089\/ars.2010.3370","article-title":"Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models","volume":"14","author":"Cheng","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.14814\/phy2.12961-BIB0006|phy212961-cit-0006","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11010-012-1531-4","article-title":"Inhibitory effect of tumor necrosis factor \u03b1 on gluconeogenesis in perfused rat liver","volume":"375","author":"Rocha","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.14814\/phy2.12961-BIB0007|phy212961-cit-0007","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pharep.2013.12.005","article-title":"Tumor necrosis factor alpha abolished the suppressive effect of insulin on hepatic glucose production and glycogenolysis stimulated by cAMP","volume":"66","author":"Rocha","year":"2014","journal-title":"Pharmacol. Rep. PR"},{"key":"10.14814\/phy2.12961-BIB0008|phy212961-cit-0008","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0026-0495(89)90129-7","article-title":"Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake","volume":"38","author":"DeFronzo","year":"1989","journal-title":"Metabolism"},{"issue":"Suppl 2","key":"10.14814\/phy2.12961-BIB0009|phy212961-cit-0009","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1055\/s-2001-18584","article-title":"Thyroid hormone excess and glucose intolerance","volume":"109","author":"Dimitriadis","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes Off. J. Ger. Soc. Endocrinol. Ger. Diabetes Assoc"},{"key":"10.14814\/phy2.12961-BIB0010|phy212961-cit-0010","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1016\/S0021-9258(18)51841-X","article-title":"Liver glycogen synthesis in intact alloxan diabetic rats","volume":"238","author":"Friedmann","year":"1963","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.12961-BIB0011|phy212961-cit-0011","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1124\/jpet.108.140210","article-title":"Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models","volume":"327","author":"Fujimori","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.14814\/phy2.12961-BIB0012|phy212961-cit-0012","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s001250050746","article-title":"Effect of feeding, fasting, and diabetes on liver glycogen synthase activity, protein, and mRNA in rats","volume":"40","author":"Gannon","year":"1997","journal-title":"Diabetologia"},{"key":"10.14814\/phy2.12961-BIB0013|phy212961-cit-0013","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0950-351X(05)80207-1","article-title":"Control of glycaemia","volume":"7","author":"Gerich","year":"1993","journal-title":"Bailli\u00e8res Clin. Endocrinol. Metab."},{"key":"10.14814\/phy2.12961-BIB0014|phy212961-cit-0014","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1464-5491.2009.02894.x","article-title":"Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications","volume":"27","author":"Gerich","year":"2010","journal-title":"Diabet. Med. J. Br. Diabet. Assoc."},{"key":"10.14814\/phy2.12961-BIB0015|phy212961-cit-0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-5793(99)00642-0","article-title":"Action of thyroid hormones at the cellular level: the mitochondrial target","volume":"452","author":"Goglia","year":"1999","journal-title":"FEBS Lett."},{"key":"10.14814\/phy2.12961-BIB0016|phy212961-cit-0016","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1006\/bbrc.1996.0629","article-title":"Triiodothyronine increases glucose transporter isotype 4 mRNA expression, glucose transport, and glycogen synthesis in adult rat cardiomyocytes in long-term culture","volume":"221","author":"Gosteli-Peter","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.14814\/phy2.12961-BIB0017|phy212961-cit-0017","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2337\/diab.46.4.541","article-title":"New insights into the role and mechanism of glycogen synthase activation by insulin","volume":"46","author":"Lawrence","year":"1997","journal-title":"Diabetes"},{"key":"10.14814\/phy2.12961-BIB0018|phy212961-cit-0018","volume-title":"Lehninger principles of biochemistry, 3rd","author":"Lehninger","year":"2000"},{"key":"10.14814\/phy2.12961-BIB0019|phy212961-cit-0019","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1476-5381.2010.01056.x","article-title":"Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes","volume":"162","author":"Lin","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.14814\/phy2.12961-BIB0020|phy212961-cit-0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1001\/archinte.1969.00300130066010","article-title":"Role of insulin in the hepatic handling of glucose","volume":"123","author":"Madison","year":"1969","journal-title":"Arch. Intern. Med."},{"key":"10.14814\/phy2.12961-BIB0021|phy212961-cit-0021","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1210\/me.2004-0542","article-title":"Cytosolic action of thyroid hormone leads to induction of hypoxia-inducible factor-1alpha and glycolytic genes","volume":"19","author":"Moeller","year":"2005","journal-title":"Mol. Endocrinol. Baltim. Md"},{"key":"10.14814\/phy2.12961-BIB0022|phy212961-cit-0022","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jdiacomp.2015.12.027","article-title":"Incidence and prevalence of thyroid dysfunction in type 1 diabetes","volume":"30","author":"Nederstigt","year":"2016","journal-title":"J. Diabetes Complications"},{"key":"10.14814\/phy2.12961-BIB0023|phy212961-cit-0023","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1530\/JOE-11-0105","article-title":"Intensive insulin treatment induces insulin resistance in diabetic rats by impairing glucose metabolism-related mechanisms in muscle and liver","volume":"211","author":"Okamoto","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.14814\/phy2.12961-BIB0024|phy212961-cit-0024","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/apha.12647","article-title":"Thyroid hormone reduces inflammatory cytokines improving glycemia control in alloxan-induced\u00a0diabetic wistar rats","volume":"217","author":"Panveloski-Costa","year":"2016","journal-title":"Acta Physiol. Oxf. Engl"},{"key":"10.14814\/phy2.12961-BIB0025|phy212961-cit-0025","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1172\/JCI579","article-title":"Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans","volume":"101","author":"Petersen","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.14814\/phy2.12961-BIB0026|phy212961-cit-0026","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1590\/S0004-27302008000200003","article-title":"Mediators\u00a0and mechanisms of pancreatic beta-cell death in type 1 diabetes","volume":"52","author":"Pirot","year":"2008","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.14814\/phy2.12961-BIB0027|phy212961-cit-0027","first-page":"254","article-title":"Excess thyroid hormone and carbohydrate metabolism","volume":"15","author":"Potenza","year":"2009","journal-title":"Endocr. Pract. Off. J. Am. Coll. Endocrinol. Am. Assoc. Clin. Endocrinol."},{"key":"10.14814\/phy2.12961-BIB0028|phy212961-cit-0028","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1021\/tx0497705","article-title":"Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase","volume":"18","author":"Sakai","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.14814\/phy2.12961-BIB0029|phy212961-cit-0029","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2215\/CJN.04010609","article-title":"Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target","volume":"5","author":"Santer","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol. CJASN"},{"key":"10.14814\/phy2.12961-BIB0030|phy212961-cit-0030","doi-asserted-by":"crossref","first-page":"E761","DOI":"10.1152\/ajpendo.2001.280.5.E761","article-title":"T(3) increases mitochondrial ATP production in oxidative muscle despite increased expression of UCP2 and -3","volume":"280","author":"Short","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.14814\/phy2.12961-BIB0031|phy212961-cit-0031","first-page":"E731","article-title":"Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion","volume":"260","author":"Shulman","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"Pt 1","key":"10.14814\/phy2.12961-BIB0032|phy212961-cit-0032","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bj2960015","article-title":"Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling","volume":"296","author":"Sutherland","year":"1993","journal-title":"Biochem. J."},{"key":"10.14814\/phy2.12961-BIB0033|phy212961-cit-0033","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.2337\/diab.43.10.1185","article-title":"Thyroid hormone increases basal and insulin-stimulated glucose transport in skeletal muscle. The role of GLUT4 glucose transporter expression","volume":"43","author":"Weinstein","year":"1994","journal-title":"Diabetes"},{"key":"10.14814\/phy2.12961-BIB0034|phy212961-cit-0034","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/1060028015573564","article-title":"Empagliflozin, an SGLT2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus: a Review of the Evidence","volume":"49","author":"White","year":"2015","journal-title":"Ann. Pharmacother."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.12961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.12961\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T23:41:59Z","timestamp":1657323719000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.12961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":35,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016,9]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.12961","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]}}}