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MV<\/jats:styled-content> is known to induce lung inflammation, while spinal cord injury (SCI<\/jats:styled-content>) is known to contribute to local inflammatory response. Interaction between MV<\/jats:styled-content> and SCI<\/jats:styled-content> was evaluated in order to assess the impact it may have on the pulmonary inflammatory profile. Sprague Dawley rats were anesthetized for 24\u00a0h and randomized to receive either MV<\/jats:styled-content> or not. The MV<\/jats:styled-content> group included C4\u2013C5 SCI, T10 SCI<\/jats:styled-content> and uninjured animals. The nonventilated (NV<\/jats:styled-content>) group included T10 SCI<\/jats:styled-content> and uninjured animals. Inflammatory cytokine profile, inflammation related to the SCI<\/jats:styled-content> level, and oxidative stress mediators were measured in the bronchoalveolar lavage (BAL<\/jats:styled-content>). The cytokine profile in BAL<\/jats:styled-content> of MV<\/jats:styled-content> animals showed increased levels of TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic>, IL<\/jats:styled-content>\u20101\u03b2<\/jats:italic>, IL<\/jats:styled-content>\u20106 and a decrease in IL<\/jats:styled-content>\u201010 (P<\/jats:italic>\u00a0=\u00a00.007) compared to the NV<\/jats:styled-content> group. SCI<\/jats:styled-content> did not modify IL<\/jats:styled-content>\u20106 and IL<\/jats:styled-content>\u201010 levels either in the MV<\/jats:styled-content> or the NV<\/jats:styled-content> groups, but cervical injury induced a decrease in IL<\/jats:styled-content>\u20101\u03b2<\/jats:italic> levels in MV<\/jats:styled-content> animals. Cervical injury also reduced MV<\/jats:styled-content>\u2010induced pulmonary oxidative stress responses by decreasing isoprostane levels while increasing heme oxygenase\u20101 level. The thoracic SCI<\/jats:styled-content> in NV<\/jats:styled-content> animals increased M\u2010CSF<\/jats:styled-content> expression and promoted antioxidant pulmonary responses with low isoprostane and high heme oxygenase\u20101 levels. SCI<\/jats:styled-content> shows a positive impact on MV<\/jats:styled-content>\u2010induced pulmonary inflammation, modulating specific lung immune and oxidative stress responses. Inflammation induced by MV<\/jats:styled-content> and SCI<\/jats:styled-content> interact closely and may have strong clinical implications since effective treatment of ventilated SCI patients may amplify pulmonary biotrauma.<\/jats:p>","DOI":"10.14814\/phy2.13009","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T02:05:16Z","timestamp":1483149916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spinal cord injury modulates the lung inflammatory response in mechanically ventilated rats: a comparative animal study"],"prefix":"10.14814","volume":"4","author":[{"given":"Karine","family":"Truflandier","sequence":"first","affiliation":[{"name":"Research Center Sacr\u00e9\u2010C\u0153ur Hospital of Montreal Department of Medicine Universit\u00e9 de Montr\u00e9al Montreal Quebec 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