{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:26:01Z","timestamp":1770513961238,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000835","name":"University of Bath","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to establish whether vigorous\u2010intensity exercise offers additional adipose\u2010related health benefits and metabolic improvements compared to energy\u2010matched moderate\u2010intensity exercise. Thirty\u2010eight sedentary overweight men (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) and postmenopausal women (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) aged 52\u00a0\u00b1\u00a05\u00a0years (mean \u00b1 standard deviations [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>]) were prescribed a 3\u2010week energy deficit (29302 <jats:styled-content style=\"fixed-case\">kJ<\/jats:styled-content>\u2219week<jats:sup>\u22121<\/jats:sup>) achieved by increased isocaloric moderate or vigorous\u2010intensity exercise (+8372 <jats:styled-content style=\"fixed-case\">kJ<\/jats:styled-content>\u2219week<jats:sup>\u22121<\/jats:sup>) and simultaneous restricted energy intake (\u221220930 <jats:styled-content style=\"fixed-case\">kJ<\/jats:styled-content>\u2219week<jats:sup>\u22121<\/jats:sup>). Participants were randomly assigned to either an energy\u2010matched vigorous (<jats:styled-content style=\"fixed-case\">VIG<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a018) or moderate (<jats:styled-content style=\"fixed-case\">MOD<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a020) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow\u2010up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted. Body mass was reduced similarly in both groups (\u2206 2.4\u00a0\u00b1\u00a01.1\u00a0kg and \u2206 2.4\u00a0\u00b1\u00a01.4\u00a0kg, respectively, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Insulinemic responses to a standard glucose load decreased similarly at follow\u2010up relative to baseline in <jats:styled-content style=\"fixed-case\">VIG<\/jats:styled-content> (\u2206 8.6\u00a0\u00b1\u00a015.4\u00a0nmol.120\u00a0min.l<jats:sup>\u22121<\/jats:sup>) and <jats:styled-content style=\"fixed-case\">MOD<\/jats:styled-content> (\u2206 5.4\u00a0\u00b1\u00a08.5\u00a0nmol.120\u00a0min.l<jats:sup>\u22121<\/jats:sup>; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Expression of <jats:styled-content style=\"fixed-case\">SREBP<\/jats:styled-content>\u20101c and <jats:styled-content style=\"fixed-case\">FAS<\/jats:styled-content> in adipose tissue was significantly down\u2010regulated, whereas expression of <jats:styled-content style=\"fixed-case\">PDK<\/jats:styled-content>4 and hormone\u2010sensitive lipase (<jats:styled-content style=\"fixed-case\">HSL<\/jats:styled-content>) was significantly up\u2010regulated in both groups (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Thus, when energy expenditure and energy deficit are matched, vigorous or moderate\u2010intensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression.<\/jats:p>","DOI":"10.14814\/phy2.13026","type":"journal-article","created":{"date-parts":[[2016,12,31]],"date-time":"2016-12-31T02:05:16Z","timestamp":1483149916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women"],"prefix":"10.14814","volume":"4","author":[{"given":"Jean\u2010Philippe","family":"Walhin","sequence":"first","affiliation":[{"name":"Department for Health University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie C.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department for Health University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Betts","sequence":"additional","affiliation":[{"name":"Department for Health University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dylan","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department for Health University of Bath Bath UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/ptsp.2002.0123"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.058"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2009.04.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28085"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008483-200003000-00003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0033"},{"key":"e_1_2_7_8_1","first-page":"A505","article-title":"Regulation of leptin by agouti and insulin","volume":"12","author":"Claycombe K. 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