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Ninety\u2010six Swiss mice received intraperitoneal injection of Haloperidol (1\u00a0mg\/kg) to block dopaminergic receptors. <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>a receptors antagonists Bicuculline (1 and 5\u00a0mg\/kg) and Flumazenil (3 and 6\u00a0mg\/kg) were used for the assessment of the interaction among these neurotransmitters, in this PD model. The motor behavior of the animals was evaluated in the catalepsy test (30, 60, and 90\u00a0min after drugs application), through open field test (after 60\u00a0min) and trough functional gait assessment (after 60\u00a0min). Both Bicuculline and Flumazenil were able to partially reverse catalepsy induced by Haloperidol. In the open field test, Haloperidol reduced the number of horizontal and vertical exploration of the animals, which was not reversed trough application of <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>a antagonists. Furthermore, the functional gait assessment was not sensitive enough to detect motor changes in this animal model of PD. There is an interaction between dopamine and <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> in the basal ganglia and the blocking <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>a receptors may have therapeutic potential in the treatment of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p>","DOI":"10.14814\/phy2.13081","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:10:09Z","timestamp":1490746209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of <scp>GABA<\/scp>a receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice"],"prefix":"10.14814","volume":"5","author":[{"given":"Karla De Michelis","family":"Mograbi","sequence":"first","affiliation":[{"name":"Laboratory of Biophysiopharmacology Universidade Federal de Mato Grosso do Sul Campo Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolini Ferreira","family":"de Castro","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysiopharmacology Universidade Federal de Mato Grosso do Sul Campo Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jainny Aniely Rocha","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysiopharmacology Universidade Federal de Mato Grosso do Sul Campo Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Jean Barbosa","family":"Sales","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysiopharmacology Universidade Federal de Mato Grosso do Sul Campo Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene","family":"Covolan","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology Universidade Federal de S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane Aparecida","family":"Del Bel","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology Universidade de S\u00e3o Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Schiaveto","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Biophysiopharmacology Universidade Federal de Mato Grosso do Sul Campo Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052323"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"A mouse model of non\u2010motor symptom on Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions","volume":"27","author":"Bonito\u2010Oliva A.","year":"2014","journal-title":"Front. 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