{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:20:21Z","timestamp":1767986421448,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010DK92179"],"award-info":[{"award-number":["R01\u2010DK92179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1\u2010TR000135"],"award-info":[{"award-number":["UL1\u2010TR000135"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum\u2010derived bovine immunoglobulin\/protein isolate (SBI), an oral nutritional therapy, is efficacious in diverse diarrheal diseases. In an open\u2010label study in 15 patients with irritable bowel syndrome\u2010diarrhea (IBS\u2010D), we evaluated effects of SBI (5.0\u00a0g, twice a day) for 8\u00a0weeks on safety, on bowel function and abdominal pain, tryptophan metabolism (K:T ratio), intestinal permeability (<jats:sup>13<\/jats:sup>C\u2010mannitol and lactulose excretion), bile acid synthesis (fasting serum FGF\u201019 and C4), duodenal and stool microbiome, and the expression of 90 genes related to inflammation, immune function, and tight junctions in duodenal mucosa. Statistical analysis (paired tests, baseline vs. treatment) was based on intention to treat (ITT) principles. One of 15 Caucasian patients (13F, 2M, age 40.3\u00a0\u00b1\u00a02.3y, BMI 34.3\u00a0\u00b1\u00a03.0\u00a0kg\/m<jats:sup>2<\/jats:sup>) withdrew without completing studies. There were improvements in stools\/day (decrease, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), ease of passage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035), and evacuation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) with SBI therapy. Worst pain severity was numerically reduced in last 2\u00a0weeks' treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.078). Duodenal mucosal mRNA expression; serum C4, FGF\u201019, and KT ratio; small bowel or colon permeability; and stool microbiome were not significantly different after SBI therapy, compared to baseline. In duodenal brushings, there was considerable microbiota structure difference (<jats:italic>\u03b2<\/jats:italic> diversity analysis <jats:italic>P<\/jats:italic>\u00a0=\u00a00.072, UniFrac) and, on taxonomic analysis, increased abundance of <jats:italic>Proteobacteria Burkholderiales, Firmicutes Catonella,<\/jats:italic> and unclassified genus organisms with SBI therapy. Thus, SBI therapy for 8\u00a0weeks in IBS\u2010D patients is associated with improved bowel function; the mechanism of benefit is unclear, though there were microbiota structure differences in duodenal brushings. Further studies in patients with low\u2010grade inflammation and intestinal barrier dysfunction at baseline are indicated.<\/jats:p>","DOI":"10.14814\/phy2.13170","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T01:10:34Z","timestamp":1489021834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Potential mechanisms of effects of serum\u2010derived bovine immunoglobulin\/protein isolate therapy in patients with diarrhea\u2010predominant irritable bowel syndrome"],"prefix":"10.14814","volume":"5","author":[{"given":"Nelson","family":"Valentin","sequence":"first","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Carlson","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean C.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Eckert","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duane","family":"Burton","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER) Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey L.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Entera Health Inc. 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