{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:16:47Z","timestamp":1791415007395,"version":"4.3.3"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vascular bubble models, which present a realistic biophysical approach, hold great promise for devising suitable diver decompression procedures. Nanobubbles were found to nucleate on a flat hydrophobic surface, expanding to form bubbles after decompression. Such active hydrophobic spots (<jats:styled-content style=\"fixed-case\">AHS<\/jats:styled-content>) were formed from lung surfactants on the luminal aspect of ovine blood vessels. Many of the phenomena observed in these bubbling vessels correlated with those known to occur in diving. On the basis of our previous studies, which proposed a new model for the formation of arterial bubbles, we now suggest the biophysical model presented herein. There are two phases of bubble expansion after decompression. The first is an extended initiation phase, during which nanobubbles are transformed into gas micronuclei and begin to expand. The second, shorter phase is one of simple diffusion\u2010driven growth, the inert gas tension in the blood remaining almost constant during bubble expansion. Detachment of the bubble occurs when its buoyancy exceeds the intermembrane force. Three mechanisms underlying the appearance of arterial bubbles should be considered: patent foramen ovale, intrapulmonary arteriovenous anastomoses, and the evolution of bubbles in the distal arteries with preference for the spinal cord. Other parameters that may be quantified include age, acclimation, distribution of bubble volume, <jats:styled-content style=\"fixed-case\">AHS<\/jats:styled-content>, individual sensitivity, and frequency of bubble formation. We believe that the vascular bubble model we propose adheres more closely to proven physiological processes. Its predictability may therefore be higher than other models, with appropriate adjustments for decompression illness (<jats:styled-content style=\"fixed-case\">DCI<\/jats:styled-content>) data.<\/jats:p>","DOI":"10.14814\/phy2.13191","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T01:40:41Z","timestamp":1490060441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A biophysical vascular bubble model for devising decompression procedures"],"prefix":"10.14814","volume":"5","author":[{"given":"Ran","family":"Arieli","sequence":"first","affiliation":[{"name":"Israel Naval Medical Institute, Haifa, and Eliachar Research Laboratory Western Galilee Medical Center Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Marmur","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Technion\u2010Israel Institute of Technology Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(86)90148-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2006.07.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.11.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2011.02.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2012.11.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.04.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2014.05.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.11.010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2015.05.001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00649.2016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.00696"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-103589"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300436"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9370-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880040110"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2009.00884.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02409-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00723.1999"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3357\/AMHP.4392.2015"},{"key":"e_1_2_6_21_1","unstructured":"D'Aoust B. 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