{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:37:01Z","timestamp":1772890621537,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32HL114272-01A1"],"award-info":[{"award-number":["F32HL114272-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14SDG18320033"],"award-info":[{"award-number":["14SDG18320033"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.14814\/phy2.13213","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T20:10:16Z","timestamp":1491941416000},"page":"e13213","source":"Crossref","is-referenced-by-count":26,"title":["Cholinergic agonists reduce blood pressure in a mouse model of systemic lupus erythematosus"],"prefix":"10.14814","volume":"5","author":[{"given":"Amber S.","family":"Fairley","sequence":"first","affiliation":[{"name":"Institute for Cardiovascular and Metabolic Diseases; University of North Texas Health Science Center; Fort Worth Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisa W.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular and Metabolic Diseases; University of North Texas Health Science Center; Fort Worth Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"10.14814\/phy2.13213-BIB0001|phy213213-cit-0001","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1152\/ajprenal.00507.2011","article-title":"Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria","volume":"302","author":"Agarwal","year":"2012","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.14814\/phy2.13213-BIB0002|phy213213-cit-0002","first-page":"493","article-title":"Cardiovascular risk factor screening in systemic lupus erythematosus","volume":"30","author":"Al-Herz","year":"2003","journal-title":"J. Rheumatol."},{"key":"10.14814\/phy2.13213-BIB0003|phy213213-cit-0003","first-page":"515","article-title":"Effects of nicotine and tobacco smoke on blood pressure and release of catecholamines from the adrenal glands","volume":"25","author":"Armitage","year":"1965","journal-title":"Brit. J. Pharmacol."},{"key":"10.14814\/phy2.13213-BIB0004|phy213213-cit-0004","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1566-0702(00)00233-2","article-title":"Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation","volume":"85","author":"Borovikova","year":"2000a","journal-title":"Auto. Neurosci."},{"key":"10.14814\/phy2.13213-BIB0005|phy213213-cit-0005","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000b","journal-title":"Nature"},{"key":"10.14814\/phy2.13213-BIB0006|phy213213-cit-0006","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archinte.1976.03630090033009","article-title":"Hypertension and renal disease in systemic lupus erythematosus","volume":"136","author":"Budman","year":"1976","journal-title":"Arch. Intern. Med."},{"key":"10.14814\/phy2.13213-BIB0007|phy213213-cit-0007","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/0961203308098191","article-title":"Lupus and T cells","volume":"18","author":"Cava","year":"2009","journal-title":"Lupus"},{"key":"10.14814\/phy2.13213-BIB0008|phy213213-cit-0008","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2261-12-38","article-title":"Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats","volume":"12","author":"Chen","year":"2012","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.14814\/phy2.13213-BIB0009|phy213213-cit-0009","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1152\/ajpregu.00373.2009","article-title":"Lymphocyte responses exacerbate angiotensin II-dependent hypertension","volume":"298","author":"Crowley","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13213-BIB0010|phy213213-cit-0010","doi-asserted-by":"crossref","first-page":"R1136","DOI":"10.1152\/ajpregu.00298.2009","article-title":"T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats","volume":"298","author":"Miguel","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13213-BIB0011|phy213213-cit-0011","doi-asserted-by":"crossref","first-page":"576","DOI":"10.2119\/2007-00067.Dowling","article-title":"Nicotine inhibits cytokine production by placenta cells via NFKB: potential role in pregnancy-induced hypertension","volume":"13","author":"Dowling","year":"2007","journal-title":"Mol. Med."},{"key":"10.14814\/phy2.13213-BIB0012|phy213213-cit-0012","doi-asserted-by":"crossref","first-page":"208.e9","DOI":"10.1016\/j.ajog.2012.06.021","article-title":"Sex-specific effects of nicotine exposure on developmental programming of blood pressure and vascular reactivity in the C57Bl\/6J mouse","volume":"207","author":"Fox","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.14814\/phy2.13213-BIB0013|phy213213-cit-0013","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2119\/2006-00108.Goldstein","article-title":"Cholinergic anti-inflammatory pathway activity and high mobility group box-1 (HMGB1) serum levels in patients with rheumatoid arthritis","volume":"13","author":"Goldstein","year":"2007","journal-title":"Mol. Med."},{"key":"10.14814\/phy2.13213-BIB0014|phy213213-cit-0014","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II-induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.14814\/phy2.13213-BIB0015|phy213213-cit-0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF00053022","article-title":"Nicotine and sympathetic neurotransmission","volume":"10","author":"Haass","year":"1996","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.14814\/phy2.13213-BIB0016|phy213213-cit-0016","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/hr.2013.99","article-title":"Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats","volume":"37","author":"Heijnen","year":"2013","journal-title":"Hypertens. Res."},{"key":"10.14814\/phy2.13213-BIB0017|phy213213-cit-0017","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2006080918","article-title":"Mycophenolate mofetil treatment improves hypertension in patients with psoriasis and rheumatoid arthritis","volume":"17","author":"Herrera","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13213-BIB0018|phy213213-cit-0018","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)70151-3","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"10.14814\/phy2.13213-BIB0019|phy213213-cit-0019","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/096120339600500110","article-title":"Heart rate variability and cardiac autonomic function in systemic lupus erythematosus","volume":"5","author":"Lagana","year":"1996","journal-title":"Lupus"},{"key":"10.14814\/phy2.13213-BIB0020|phy213213-cit-0020","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/CIRCRESAHA.111.245563","article-title":"Role of the cholinergic anti-inflammatory pathway in murine autoimmune myocarditis","volume":"109","author":"Leib","year":"2011","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13213-BIB0021|phy213213-cit-0021","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/HYPERTENSIONAHA.110.160077","article-title":"Dysfunction of the cholinergic anti-inflammatory pathway mediated organ damage in hypertension","volume":"57","author":"Li","year":"2011","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13213-BIB0022|phy213213-cit-0022","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/ard.53.10.671","article-title":"Autonomic neuropathy in systemic lupus erythematosus: cardiovascular autonomic function assessment","volume":"53","author":"Liote","year":"1994","journal-title":"Ann. Rheum. Dis."},{"key":"10.14814\/phy2.13213-BIB0023|phy213213-cit-0023","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/qjmed\/92.2.97","article-title":"Cardiovascular autonomic nervous system dysfunction in patients with rheumatoid arthritis and systemic lupus erythematosus","volume":"92","author":"Louthrenoo","year":"1999","journal-title":"Q J. Med."},{"key":"10.14814\/phy2.13213-BIB0024|phy213213-cit-0024","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1152\/ajpregu.00386.2011","article-title":"Blood pressure in a hypertensive mouse model of SLE is not salt-sensitive","volume":"301","author":"Mathis","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13213-BIB0025|phy213213-cit-0025","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/HYPERTENSIONAHA.111.190009","article-title":"Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus","volume":"59","author":"Mathis","year":"2012","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13213-BIB0026|phy213213-cit-0026","doi-asserted-by":"crossref","first-page":"R711","DOI":"10.1152\/ajpregu.00602.2012","article-title":"Hypertension in an experimental model of systemic lupus erythematosus occures independently of the renal nerves","volume":"301","author":"Mathis","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13213-BIB0027|phy213213-cit-0027","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1161\/HYPERTENSIONAHA.114.04006","article-title":"Preventing autoimmunity protects against the development of hypertension and renal injury","volume":"64","author":"Mathis","year":"2014","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13213-BIB0028|phy213213-cit-0028","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-2249.1997.4501466.x","article-title":"Autonomic nervous dysfunction in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA): possible pathogenic role of autoantibodies to autonomic nervous structures","volume":"110","author":"Maule","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.14814\/phy2.13213-BIB0029|phy213213-cit-0029","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCRESAHA.116.303697","article-title":"Inflammation, immunity, and hypertensive end-organ damage","volume":"116","author":"McMaster","year":"2015","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13213-BIB0030|phy213213-cit-0030","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1152\/ajpregu.00298.2009","article-title":"T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats","volume":"298","author":"Miguel","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13213-BIB0031|phy213213-cit-0031","first-page":"62","article-title":"Pain control by vagus nerve stimulation: from animal to man and back","volume":"105","author":"Multon","year":"2005","journal-title":"Acta neurol."},{"key":"10.14814\/phy2.13213-BIB0032|phy213213-cit-0032","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.4049\/jimmunol.0902212","article-title":"Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses","volume":"183","author":"Nizri","year":"2009","journal-title":"J. Immunol."},{"key":"10.14814\/phy2.13213-BIB0033|phy213213-cit-0033","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2119\/molmed.2011.00405","article-title":"alpha7 Nicotinic acetylcholine receptor (a7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex","volume":"18","author":"Olofsson","year":"2012","journal-title":"Mol. Med."},{"key":"10.14814\/phy2.13213-BIB0034|phy213213-cit-0034","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1046\/j.1523-1755.2001.00737.x","article-title":"Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure","volume":"59","author":"Rodriguez-Iturbe","year":"2001","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13213-BIB0035|phy213213-cit-0035","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Rosas-Ballina","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.14814\/phy2.13213-BIB0036|phy213213-cit-0036","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetycholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"key":"10.14814\/phy2.13213-BIB0037|phy213213-cit-0037","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3899\/jrheum.101132","article-title":"Prevalence of and factors associated with hypertension in young and old women with systemic lupus erythematosus","volume":"38","author":"Sabio","year":"2011","journal-title":"J. Rheumatol."},{"key":"10.14814\/phy2.13213-BIB0038|phy213213-cit-0038","doi-asserted-by":"crossref","first-page":"e469","DOI":"10.1371\/journal.pone.0000469","article-title":"Nicotine protects kidney from renal ischemia\/reperfusion injury through the cholinergic anti-inflammatory pathway","volume":"2","author":"Sadis","year":"2007","journal-title":"PLoS ONE"},{"key":"10.14814\/phy2.13213-BIB0039|phy213213-cit-0039","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/art.38238","article-title":"Population-based incidence and prevalence of systemic lupus erythematosus","volume":"66","author":"Somers","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.14814\/phy2.13213-BIB0040|phy213213-cit-0040","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/S0140-6736(03)13302-8","article-title":"Essential hypertension","volume":"361","author":"Staessen","year":"2003","journal-title":"Lancet"},{"key":"10.14814\/phy2.13213-BIB0041|phy213213-cit-0041","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ni1078","article-title":"Elaborate interactions between the immune and nervous systems","volume":"5","author":"Steinman","year":"2004","journal-title":"Nature Immunol."},{"key":"10.14814\/phy2.13213-BIB0042|phy213213-cit-0042","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0961203306076223","article-title":"Cardiovascular autonomic dysfunction in systemic lupus, rheuamtoid arthritis, primary Sjogren syndrome and other autoimmune diseases","volume":"16","author":"Stojanovich","year":"2007","journal-title":"Lupus"},{"key":"10.14814\/phy2.13213-BIB0043|phy213213-cit-0043","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/advan.00094.2013","article-title":"Neural control of the immune system","volume":"38","author":"Sundman","year":"2014","journal-title":"Adv. Physiol. Edu."},{"key":"10.14814\/phy2.13213-BIB0044|phy213213-cit-0044","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.14814\/phy2.13213-BIB0045|phy213213-cit-0045","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nri2566","article-title":"Reflex control of immunity","volume":"9","author":"Tracey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.14814\/phy2.13213-BIB0046|phy213213-cit-0046","first-page":"1","article-title":"Transcutaneous vagal nerve stimulation (tVNS): a new neuromodulation tool in healthy humans?","volume":"6","author":"Leusden","year":"2015","journal-title":"Front Psychol."},{"key":"10.14814\/phy2.13213-BIB0047|phy213213-cit-0047","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/art.24177","article-title":"Stimulation of nicotinic receptors attenuates collagen-induced arthritis in mice","volume":"60","author":"Maanen","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.14814\/phy2.13213-BIB0048|phy213213-cit-0048","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/HYPERTENSIONAHA.110.157685","article-title":"Tumor necrosis factor-alpha antagonist etanercept decreases blood pressure and protects the kidney in a mouse model of systemic lupus erythematosus","volume":"56","author":"Venegas-Pont","year":"2010","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13213-BIB0049|phy213213-cit-0049","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor a7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.14814\/phy2.13213-BIB0050|phy213213-cit-0050","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.14814\/phy2.13213-BIB0051|phy213213-cit-0051","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306010","article-title":"Renal denervation prevents immune cell activation and renal inflammation in angiotensin II-induced hypertension","volume":"117","author":"Xiao","year":"2015","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13213-BIB0052|phy213213-cit-0052","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ki.2008.94","article-title":"Cholinergic agonists attenuate renal ischemia-reperfusion injury in rats","volume":"74","author":"Yeboah","year":"2008","journal-title":"Kidney Int."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13213\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T11:05:09Z","timestamp":1521198309000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13213","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}