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An untoward cardiac incident is related to the degree of <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>, suggesting that the occurrence of a significant cardiac event is significantly higher for individuals with <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>. Thus, understanding the fundamental hemodynamic mechanisms mediating the response to myocardial ischemia has the potential to positively impact individuals and families living with <jats:styled-content style=\"fixed-case\">SCI<\/jats:styled-content>. Accordingly, we systematically investigated if thoracic level 5 spinal cord transection (T<jats:sub>5<\/jats:sub>X; paraplegia) alters the arterial blood pressure response to coronary artery occlusion and if the different arterial blood pressure responses to coronary artery occlusion between intact and paraplegic mice are mediated by changes in cardiac output and or systemic peripheral resistance and whether differences in cardiac output are caused by changes in heart rate and or stroke volume. To achieve this goal, the tolerance to 3\u00a0min of coronary artery occlusion was determined in conscious intact and paraplegic mice. Paraplegic mice had an impaired ability to maintain arterial blood pressure during coronary artery occlusion as arterial pressure fell to near lethal levels by 1.38\u00a0\u00b1\u00a00.64\u00a0min. The lower arterial pressure was mediated by a lower cardiac output as systemic peripheral resistance was elevated in paraplegic mice. The lower cardiac output was mediated by a reduced heart rate and stroke volume. These results indicate that in paraplegic mice, the arterial pressure response to coronary artery occlusion is hemodynamically mediated primarily by cardiac output which is determined by heart rate and stroke volume.<\/jats:p>","DOI":"10.14814\/phy2.13214","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:13:19Z","timestamp":1490314399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fundamental hemodynamic mechanisms mediating the response to myocardial ischemia in conscious paraplegic mice: cardiac output versus peripheral resistance"],"prefix":"10.14814","volume":"5","author":[{"given":"Heidi L.","family":"Lujan","sequence":"first","affiliation":[{"name":"Department of Physiology Wayne State University School of Medicine Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"DiCarlo","sequence":"additional","affiliation":[{"name":"Department of Physiology Wayne State University School of Medicine Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1937.sp003485"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01818891"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013412"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1310\/sci1204-35"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102161"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1992.136"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9993(93)90036-A"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/0003-9993(94)90669-6","article-title":"Cardiac stress testing with thallium\u2010201 imaging reveals silent ischemia in individuals with paraplegia","volume":"75","author":"Bauman W. 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