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Patients that receive lithium therapy develop polyuria associated\n                    <jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>\n                    that might be secondary to downregulation of renal\n                    <jats:styled-content style=\"fixed-case\">AQP<\/jats:styled-content>\n                    2. We hypothesized that\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    \u2010His attenuates indices of\n                    <jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>\n                    associated with lithium treatment. Eight\u2010week\u2010old male C57\/\n                    <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\n                    6 mice consumed chow supplemented with LiCl (40\u00a0mmol\/kg diets) for 14\u00a0days. For the last 7\u00a0days mice received either\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    \u2010His [30\u00a0\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/(kg\u00a0day), i.v.;\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    ] or vehicle (Veh) via minipump. Control (Con) mice consumed standard chow for 14\u00a0days. Compared to Con mice, 14\u2010d LiCl treatment elevated water intake and urine volume, and decreased urine osmolality, regardless of\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    \u2010His or Veh administration. These data indicate that\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    \u2010His treatment does not attenuate indices of\n                    <jats:styled-content style=\"fixed-case\">NDI<\/jats:styled-content>\n                    evoked by lithium. Unexpectedly, epididymal fat mass was lower, adipocyte\n                    <jats:styled-content style=\"fixed-case\">UCP<\/jats:styled-content>\n                    1\n                    <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>\n                    and protein expression were higher, and multilocular lipid morphology was enhanced, in LiCl\u2010fed mice treated with\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    \u2010His versus vehicle. The beiging of white adipose tissue is a novel metabolic benefit of manipulating the\n                    <jats:styled-content style=\"fixed-case\">sPRR<\/jats:styled-content>\n                    in the context of lithium\u2010induced NDI.\n                  <\/jats:p>","DOI":"10.14814\/phy2.13410","type":"journal-article","created":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T20:10:41Z","timestamp":1510690241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The soluble (Pro) renin receptor does not influence lithium\u2010induced diabetes insipidus but does provoke beiging of white adipose tissue in mice"],"prefix":"10.14814","volume":"5","author":[{"given":"Kevin T.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Utah Salt Lake City Utah"},{"name":"College of Health University of Utah Salt Lake City Utah"},{"name":"Molecular Medicine Program University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Salt Lake City Utah"},{"name":"Research Service Veterans Affairs Medical Center Salt Lake City Utah"},{"name":"Institute of Hypertension Sun Yat\u2010sen University Zhongshan School of Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Salt Lake City Utah"},{"name":"Research Service Veterans Affairs Medical Center Salt Lake City Utah"},{"name":"Institute of Hypertension Sun Yat\u2010sen University Zhongshan School of Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Salt Lake City Utah"},{"name":"Research Service Veterans Affairs Medical Center Salt Lake City Utah"},{"name":"Institute of Hypertension Sun Yat\u2010sen University Zhongshan School of Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Salt Lake City Utah"},{"name":"Research Service Veterans Affairs Medical Center Salt Lake City Utah"},{"name":"Institute of Hypertension Sun Yat\u2010sen University Zhongshan School of Medicine Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"David Symons","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Salt Lake City Utah"},{"name":"College of Health University of Utah Salt Lake City Utah"},{"name":"Molecular Medicine Program University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2016.12.012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000089566.28106.F6"},{"key":"e_1_2_7_4_1","article-title":"Soluble (Pro) renin receptor is a predictor of gestational diabetes mellitus","author":"Bonakdaran S.","year":"2016","journal-title":"Curr. 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