{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:15:52Z","timestamp":1789071352713,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK105118"],"award-info":[{"award-number":["R01 DK105118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.14814\/phy2.13443","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T21:15:18Z","timestamp":1506374118000},"page":"e13443","source":"Crossref","is-referenced-by-count":203,"title":["Gut inflammation and dysbiosis in human motor neuron disease"],"prefix":"10.14814","volume":"5","author":[{"given":"Julie","family":"Rowin","sequence":"first","affiliation":[{"name":"Wellness and Integrative Neurology; Westchester Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglin","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology; Department of Medicine; University of Illinois at Chicago; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology; Department of Medicine; University of Illinois at Chicago; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-3133","authenticated-orcid":false,"given":"Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology; Department of Medicine; University of Illinois at Chicago; Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"10.14814\/phy2.13443-BIB0001|phy213443-cit-0001","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fncel.2013.00153","article-title":"Alzheimer's disease and the microbiome","volume":"7","author":"Bhattacharjee","year":"2013","journal-title":"Front Cell Neurosci."},{"key":"10.14814\/phy2.13443-BIB0002|phy213443-cit-0002","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrgastro.2014.40","article-title":"A role for the gut microbiota in IBS","volume":"11","author":"Collins","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.14814\/phy2.13443-BIB0003|phy213443-cit-0003","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3389\/fmicb.2016.01479","article-title":"Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing","volume":"7","author":"Fang","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.14814\/phy2.13443-BIB0004|phy213443-cit-0004","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/14660820310017344","article-title":"A survey of clinicians' practice in the symptomatic treatment of ALS","volume":"4","author":"Forshew","year":"2003","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord."},{"key":"10.14814\/phy2.13443-BIB0005|phy213443-cit-0005","doi-asserted-by":"crossref","first-page":"e28032","DOI":"10.1371\/journal.pone.0028032","article-title":"Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease","volume":"6","author":"Forsyth","year":"2011","journal-title":"PLoS ONE"},{"key":"10.14814\/phy2.13443-BIB0006|phy213443-cit-0006","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"},{"key":"10.14814\/phy2.13443-BIB0007|phy213443-cit-0007","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.clnu.2016.08.015","article-title":"Clinical and metabolic response to probiotic supplementation in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Kouchaki","year":"2017","journal-title":"Clin. Nutr."},{"key":"10.14814\/phy2.13443-BIB0008|phy213443-cit-0008","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/WNL.0b013e3181bc01a4","article-title":"Woolley SC and Quality Standards Subcommittee of the American Academy of N. Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive\/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"73","author":"Miller","year":"2009","journal-title":"Neurology"},{"key":"10.14814\/phy2.13443-BIB0009|phy213443-cit-0009","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fmicb.2016.00455","article-title":"Gut microbiota diversity and human diseases: should we reintroduce key predators in our ecosystem?","volume":"7","author":"Mosca","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.14814\/phy2.13443-BIB0010|phy213443-cit-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12765","article-title":"Intestinal dysbiosis and probiotic applications in autoimmune diseases","volume":"152","author":"Oliveira","year":"2017","journal-title":"Immunology"},{"key":"10.14814\/phy2.13443-BIB0011|phy213443-cit-0011","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1600-0404.2010.01333.x","article-title":"Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?","volume":"122","author":"Rentzos","year":"2010","journal-title":"Acta Neurol. Scand."},{"issue":"1469-1480","key":"10.14814\/phy2.13443-BIB0012|phy213443-cit-0012","first-page":"e12","article-title":"Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson's disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.14814\/phy2.13443-BIB0013|phy213443-cit-0013","doi-asserted-by":"crossref","first-page":"13","DOI":"10.29245\/2572.942X\/2017\/6.1136","article-title":"Commentary: target intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis","volume":"2","author":"Sun","year":"2017","journal-title":"J Neurol Neuromed"},{"key":"10.14814\/phy2.13443-BIB0014|phy213443-cit-0014","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.gendis.2014.08.001","article-title":"Exploring gut microbes in human health and disease: pushing the envelope","volume":"1","author":"Sun","year":"2014","journal-title":"Genes Dis."},{"key":"10.14814\/phy2.13443-BIB0015|phy213443-cit-0015","first-page":"375","article-title":"Does the gut drive ALS progression?","volume":"5","author":"Sun","year":"2015","journal-title":"Future Medicine."},{"key":"10.14814\/phy2.13443-BIB0016|phy213443-cit-0016","first-page":"1","volume":"53","author":"Tamboli","year":"2004","journal-title":"Dysbiosis in Inflammatory Bowel Disease. Gut."},{"key":"10.14814\/phy2.13443-BIB0017|phy213443-cit-0017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/146608299300079484","article-title":"Gastrointestinal dysfunction in amyotrophic lateral sclerosis","volume":"1","author":"Toepfer","year":"1999","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord."},{"key":"10.14814\/phy2.13443-BIB0018|phy213443-cit-0018","first-page":"21","article-title":"Fecal calprotectin in inflammatory bowel disease","volume":"9","author":"Walsham","year":"2016","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.14814\/phy2.13443-BIB0019|phy213443-cit-0019","doi-asserted-by":"crossref","first-page":"e12356","DOI":"10.14814\/phy2.12356","article-title":"Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model","volume":"3","author":"Wu","year":"2015a","journal-title":"Physiol. Rep."},{"key":"10.14814\/phy2.13443-BIB0020|phy213443-cit-0020","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/gutjnl-2014-307436","article-title":"Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis","volume":"64","author":"Wu","year":"2015b","journal-title":"Gut"},{"key":"10.14814\/phy2.13443-BIB0021|phy213443-cit-0021","volume-title":"Mechanisms underlying host-microbiome interactions in pathophysiology of human diseases","author":"Xia","year":"2017"},{"key":"10.14814\/phy2.13443-BIB0022|phy213443-cit-0022","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2008.09.017","article-title":"Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)","volume":"206","author":"Zhang","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.14814\/phy2.13443-BIB0023|phy213443-cit-0023","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clinthera.2016.12.014","article-title":"Target Intestinal microbiota to alleviate disease progression in amyotrophic lateral sclerosis","volume":"39","author":"Zhang","year":"2017","journal-title":"Clin. Ther."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13443","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13443\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T11:39:50Z","timestamp":1521200390000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":23,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,9]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13443","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}