{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:49:50Z","timestamp":1778939390871,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL66072"],"award-info":[{"award-number":["R01 HL66072"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL51971"],"award-info":[{"award-number":["P01 HL51971"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121334"],"award-info":[{"award-number":["P20GM121334"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.14814\/phy2.13461","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T20:10:21Z","timestamp":1508443821000},"page":"e13461","source":"Crossref","is-referenced-by-count":30,"title":["Consequences of advanced aging on renal function in chronic hyperandrogenemic female rat model: implications for aging women with polycystic ovary syndrome"],"prefix":"10.14814","volume":"5","author":[{"given":"Chetan N.","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Physiology; The Women's Health Research Center; University of Mississippi Medical Center; Jackson Mississippi"},{"name":"Department of Biophysics; The Women's Health Research Center; University of Mississippi Medical Center; Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine C.","family":"Racusen","sequence":"additional","affiliation":[{"name":"Department of Pathology; Johns Hopkins University School of Medicine; Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane F.","family":"Reckelhoff","sequence":"additional","affiliation":[{"name":"Department of Physiology; The Women's Health Research Center; University of Mississippi Medical Center; Jackson Mississippi"},{"name":"Department of Biophysics; The Women's Health Research Center; University of Mississippi Medical Center; Jackson Mississippi"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"10.14814\/phy2.13461-BIB0001|phy213461-cit-0001","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.14814\/phy2.13461-BIB0002|phy213461-cit-0002","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/gerona\/gls171","article-title":"Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity","volume":"67","author":"Baylis","year":"2012","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.14814\/phy2.13461-BIB0003|phy213461-cit-0003","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejogrb.2010.08.024","article-title":"The association of urinary albumin excretion and metabolic complications in polycystic ovary syndrome","volume":"154","author":"Caglar","year":"2011","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.14814\/phy2.13461-BIB0004|phy213461-cit-0004","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1161\/ATVBAHA.114.304136","article-title":"Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness: the Coronary Artery Risk Development in Young Adults Women's study","volume":"34","author":"Calderon-Margalit","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.14814\/phy2.13461-BIB0005|phy213461-cit-0005","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1210\/en.2015-1617","article-title":"Cardiometabolic effects of chronic hyperandrogenemia in a new model of postmenopausal polycystic ovary syndrome","volume":"157","author":"Dalmasso","year":"2016","journal-title":"Endocrinology"},{"key":"10.14814\/phy2.13461-BIB0006|phy213461-cit-0006","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1017\/S1462399408000598","article-title":"Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications","volume":"10","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"10.14814\/phy2.13461-BIB0007|phy213461-cit-0007","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tem.2007.07.003","article-title":"Abdominal adiposity and the polycystic ovary syndrome","volume":"18","author":"Escobar-Morreale","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"10.14814\/phy2.13461-BIB0008|phy213461-cit-0008","first-page":"176","article-title":"Association of glomerular filtration rate with inflammation in polycystic ovary syndrome","volume":"9","author":"Gozukara","year":"2015","journal-title":"Int. J. Fertil. Steril."},{"key":"10.14814\/phy2.13461-BIB0009|phy213461-cit-0009","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1210\/jc.2009-1693","article-title":"Extremes of endogenous testosterone are associated with increased risk of incident coronary events in older women","volume":"95","author":"Laughlin","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.14814\/phy2.13461-BIB0010|phy213461-cit-0010","doi-asserted-by":"crossref","first-page":"R708","DOI":"10.1152\/ajpregu.00411.2014","article-title":"Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats","volume":"308","author":"Maranon","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13461-BIB0011|phy213461-cit-0011","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1089\/jwh.2015.5441","article-title":"Cardiovascular disease and 10-year mortality in postmenopausal women with clinical features of polycystic ovary syndrome","volume":"25","author":"Merz","year":"2016","journal-title":"J. Women's Health"},{"key":"10.14814\/phy2.13461-BIB0012|phy213461-cit-0012","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4158\/EP.14.2.193","article-title":"Premicroalbuminuria in women with polycystic ovary syndrome: a metabolic risk marker","volume":"14","author":"Patel","year":"2008","journal-title":"Endocr. Pract."},{"key":"10.14814\/phy2.13461-BIB0013|phy213461-cit-0013","doi-asserted-by":"crossref","first-page":"F395","DOI":"10.1152\/ajprenal.00454.2015","article-title":"Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-alpha ratio and attenuating T-cell infiltration","volume":"311","author":"Patil","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.14814\/phy2.13461-BIB0014|phy213461-cit-0014","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1210\/jc.2015-2123","article-title":"Androgen profile through life in women with polycystic ovary syndrome: a Nordic multicenter collaboration study","volume":"100","author":"Pinola","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.14814\/phy2.13461-BIB0015|phy213461-cit-0015","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/0024-3205(94)00521-4","article-title":"Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging","volume":"55","author":"Reckelhoff","year":"1994","journal-title":"Life Sci."},{"key":"10.14814\/phy2.13461-BIB0016|phy213461-cit-0016","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1161\/01.HYP.31.1.435","article-title":"Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats","volume":"31","author":"Reckelhoff","year":"1998","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13461-BIB0017|phy213461-cit-0017","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/HJH.0b013e328344db3a","article-title":"Renal denervation: a potential new treatment modality for polycystic ovary syndrome?","volume":"29","author":"Schlaich","year":"2011","journal-title":"J. Hypertens."},{"key":"10.14814\/phy2.13461-BIB0018|phy213461-cit-0018","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1210\/jc.2011-1677","article-title":"Cardiovascular disease and risk factors in PCOS women of postmenopausal age: a 21-year controlled follow-up study","volume":"96","author":"Schmidt","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.14814\/phy2.13461-BIB0019|phy213461-cit-0019","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.genm.2010.11.013","article-title":"Cardiovascular-renal and metabolic characterization of a rat model of polycystic ovary syndrome","volume":"8","author":"Yanes","year":"2011","journal-title":"Gend. Med."},{"key":"10.14814\/phy2.13461-BIB0020|phy213461-cit-0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5539\/gjhs.v5n1p187","article-title":"Association between metabolic syndrome and premicroalbuminuria among Iranian women with Polycystic Ovary Syndrome: a case control study","volume":"5","author":"Ziaee","year":"2012","journal-title":"Glob. J. Health Sci."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13461\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T13:00:28Z","timestamp":1521205228000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":20,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2017,11]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13461","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}