{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:43:30Z","timestamp":1773413010769,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minist\u00e8re de l\u2019\u00c9ducation, du Loisir et du Sport du Qu\u00e9bec"},{"name":"Foundation of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec"},{"name":"Reichwald Family UBC Southern Medical Program Chair in Preventive Medicine"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>\n \n The effect that cardiorespiratory fitness has on the dynamic cerebral autoregulatory capacity during changes in mean arterial pressure (\n MAP<\/jats:styled-content>\n ) remains equivocal. Using a multiple\u2010metrics approach, challenging\n MAP<\/jats:styled-content>\n across the spectrum of physiological extremes (i.e., spontaneous through forced\n MAP<\/jats:styled-content>\n oscillations), we characterized dynamic cerebral autoregulatory capacity in 19 male endurance athletes and eight controls via three methods: (1) onset of regulation (i.e., time delay before an increase in middle cerebral artery (\n MCA<\/jats:styled-content>\n ) conductance [\n MCA<\/jats:styled-content>\n blood velocity (\n MCA<\/jats:styled-content>\n v)\/\n MAP<\/jats:styled-content>\n ] and rate of regulation, after transient hypotension induced by sit\u2010to\u2010stand, and transfer function analysis (\n TFA<\/jats:styled-content>\n ) of\n MAP<\/jats:styled-content>\n and\n MCA<\/jats:styled-content>\n v responses during (2) spontaneous and (3) forced oscillations (5\u2010min of squat\u2010stand maneuvers performed at 0.05 and 0.10\u00a0Hz). Reductions in\n MAP<\/jats:styled-content>\n and mean\n MCA<\/jats:styled-content>\n v (\n MCAV<\/jats:styled-content>\n mean<\/jats:sub>\n ) during initial orthostatic stress (0\u201030\u00a0sec after sit\u2010to\u2010stand) and the prevalence of orthostatic hypotension were also determined. Onset of regulation was delayed after sit\u2010to\u2010stand in athletes (3.1\u00a0\u00b1\u00a01.7 vs. 1.5\u00a0\u00b1\u00a01.0\u00a0sec;\n P<\/jats:italic>\n \u00a0=\u00a00.03), but rate of regulation was not different between groups (0.24\u00a0\u00b1\u00a00.05 vs. 0.21\u00a0\u00b1\u00a00.09\u00a0sec\n \u22121<\/jats:sup>\n ;\n P<\/jats:italic>\n \u00a0=\u00a00.82). While both groups had comparable\n TFA<\/jats:styled-content>\n metrics during spontaneous oscillations, athletes had higher\n TFA<\/jats:styled-content>\n gain during 0.10\u00a0Hz squat\u2010stand versus recreational controls (\n P<\/jats:italic>\n \u00a0=\u00a00.01). Reductions in\n MAP<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.15) and\n MCAV<\/jats:styled-content>\n mean<\/jats:sub>\n (\n P<\/jats:italic>\n \u00a0=\u00a00.11) during orthostatic stress and the prevalence of initial orthostatic hypotension (\n P<\/jats:italic>\n \u00a0=\u00a00.65) were comparable between groups. These results indicate an intact ability of the cerebral vasculature to react to spontaneous oscillations but an attenuated capability to counter rapid and large changes in\n MAP<\/jats:styled-content>\n in individuals with elevated cardiorespiratory fitness.\n <\/jats:p>","DOI":"10.14814\/phy2.13486","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T20:10:17Z","timestamp":1510258217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness"],"prefix":"10.14814","volume":"5","author":[{"given":"Lawrence","family":"Labrecque","sequence":"first","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevan","family":"Rahimaly","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Imhoff","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Paquette","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Le Blanc","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Malenfant","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J. E.","family":"Lucas","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham United Kingdom"},{"name":"Department of Physiology University of Otago Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-7095","authenticated-orcid":false,"given":"Damian M.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Neurovascular Research Laboratory Faculty of Life Sciences and Education University of South Wales South Wales United Kingdom"},{"name":"Faculty of Medicine Reichwald Health Sciences Centre University of British Columbia\u2013Okanagan Kelowna British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Smirl","sequence":"additional","affiliation":[{"name":"Health and Exercise Sciences University of British Columbia Okanagan Kelowna British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-5044","authenticated-orcid":false,"given":"Patrice","family":"Brassard","sequence":"additional","affiliation":[{"name":"Department of Kinesiology Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec Canada"},{"name":"Research center of the Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00402.2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00854.2014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.158279"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120259"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002589"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01258.2012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.13"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00790.2016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.142"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1161\/01.STR.31.12.2895","article-title":"Dynamic cerebral autoregulation is unaffected by aging","volume":"31","author":"Carey B. J.","year":"2000","journal-title":"Stroke"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15626425"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00285.2014"},{"key":"e_1_2_7_15_1","first-page":"2859","article-title":"Gender related differences in cerebral autoregulation in older healthy subjects","volume":"2009","author":"Deegan B. M.","year":"2009","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/233339a0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12082"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.07.010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140751"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01497.2010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31824f94ed"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2014.08.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510008"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.22.1.26"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12660"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1152\/ajplegacy.1974.226.3.724","article-title":"Patterns of sympathetic neuron activity associated with Mayer waves","volume":"226","author":"Preiss G.","year":"1974","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000461"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00271.2007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.178"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00264.2015"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00667.2015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2008.08.001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.082479"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24090"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-013-2667-y"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.152066"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00328.2012"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00366.2014"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00651.2014"},{"key":"e_1_2_7_40_1","first-page":"73","volume-title":"Clinical\u00a0Autonomic Disorders","author":"Wieling W.","year":"1997"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060091"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.01.011"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.1.H233"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.13486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:54:07Z","timestamp":1696488847000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.13486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":42,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.14814\/phy2.13486"],"URL":"https:\/\/doi.org\/10.14814\/phy2.13486","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/190405","asserted-by":"object"}]},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"2017-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13486"}}