{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:48:45Z","timestamp":1781880525150,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:00:00Z","timestamp":1522281600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15-HL109843"],"award-info":[{"award-number":["R15-HL109843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK96859"],"award-info":[{"award-number":["DK96859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL116264"],"award-info":[{"award-number":["HL116264"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17GRNT33650049"],"award-info":[{"award-number":["17GRNT33650049"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SFRN2391002"],"award-info":[{"award-number":["15SFRN2391002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.14814\/phy2.13655","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T01:55:13Z","timestamp":1522634113000},"page":"e13655","source":"Crossref","is-referenced-by-count":18,"title":["The complement system in hypertension and renal damage in the Dahl SS rat"],"prefix":"10.14814","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-0891","authenticated-orcid":false,"given":"Jean F.","family":"Regal","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences; University of Minnesota Medical School, Duluth Campus; Duluth Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor F.","family":"Laule","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; University of Minnesota Medical School, Duluth Campus; Duluth Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"McCutcheon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; University of Minnesota Medical School, Duluth Campus; Duluth Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate M.","family":"Root","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; University of Minnesota Medical School, Duluth Campus; Duluth Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen","family":"Hashmat","sequence":"additional","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Mattson","sequence":"additional","affiliation":[{"name":"Department of Physiology; Medical College of Wisconsin; Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"10.14814\/phy2.13655-BIB0001|phy213655-cit-0001","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.180.2.1231","article-title":"Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL\/lpr mice","volume":"180","author":"Atkinson","year":"2008","journal-title":"J. Immunol."},{"key":"10.14814\/phy2.13655-BIB0002|phy213655-cit-0002","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/01.ASN.0000051597.27127.A1","article-title":"Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL\/lpr mice","volume":"14","author":"Bao","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13655-BIB0003|phy213655-cit-0003","doi-asserted-by":"crossref","first-page":"F953","DOI":"10.1152\/ajprenal.00329.2004","article-title":"Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure","volume":"288","author":"Basile","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.14814\/phy2.13655-BIB0004|phy213655-cit-0004","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1161\/HYPERTENSIONAHA.113.01420","article-title":"Urinary excretion of c5b-9 in severe preeclampsia: tipping the balance of complement activation in pregnancy","volume":"62","author":"Burwick","year":"2013","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0005|phy213655-cit-0005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/01.CIR.101.5.541","article-title":"Soluble complement receptor-1 protects heart, lung, and cardiac myofilament function from cardiopulmonary bypass damage","volume":"101","author":"Chai","year":"2000","journal-title":"Circulation"},{"key":"10.14814\/phy2.13655-BIB0006|phy213655-cit-0006","doi-asserted-by":"crossref","first-page":"R1136","DOI":"10.1152\/ajpregu.00298.2009","article-title":"T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats","volume":"298","author":"Miguel","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13655-BIB0007|phy213655-cit-0007","doi-asserted-by":"crossref","first-page":"F734","DOI":"10.1152\/ajprenal.00454.2010","article-title":"Infiltrating T lymphocytes in the kidney increase oxidative stress and participate in the development of hypertension and renal disease","volume":"300","author":"Miguel","year":"2011a","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.14814\/phy2.13655-BIB0008|phy213655-cit-0008","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/HYPERTENSIONAHA.110.154302","article-title":"High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney","volume":"57","author":"Miguel","year":"2011b","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0009|phy213655-cit-0009","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/sj.jhh.1002129","article-title":"Plasma levels of complement C3 is associated with development of hypertension: a longitudinal cohort study","volume":"21","author":"Engstrom","year":"2007","journal-title":"J. Hum. Hypertens."},{"key":"10.14814\/phy2.13655-BIB0010|phy213655-cit-0010","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1161\/HYPERTENSIONAHA.114.04468","article-title":"Null mutation of the nicotinamide adenine dinucleotide phosphate-oxidase subunit p67phox protects the Dahl-S rat from salt-induced reductions in medullary blood flow and glomerular filtration rate","volume":"65","author":"Evans","year":"2015","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0011|phy213655-cit-0011","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/HYPERTENSIONAHA.114.04179","article-title":"Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats","volume":"65","author":"Geurts","year":"2015","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0012|phy213655-cit-0012","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2249.1997.511e-ce1408.x","article-title":"Local therapy with soluble\u00a0complement receptor 1 (sCR1) suppresses inflammation in rat mono-articular arthritis","volume":"110","author":"Goodfellow","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.14814\/phy2.13655-BIB0013|phy213655-cit-0013","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/ajh.2011.214","article-title":"Role of complement 3a in the synthetic phenotype and angiotensin II-production in vascular smooth muscle cells from spontaneously hypertensive rats","volume":"25","author":"Han","year":"2012","journal-title":"Am. J. Hypertens."},{"key":"10.14814\/phy2.13655-BIB0014|phy213655-cit-0014","doi-asserted-by":"crossref","first-page":"F555","DOI":"10.1152\/ajprenal.00594.2015","article-title":"Interleukin-6 inhibition attenuates hypertension and associated renal damage in Dahl salt-sensitive rats","volume":"311","author":"Hashmat","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.14814\/phy2.13655-BIB0015|phy213655-cit-0015","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/10641963.2013.789042","article-title":"Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats","volume":"36","author":"Ikeda","year":"2014","journal-title":"Clin. Exp. Hypertens."},{"key":"10.14814\/phy2.13655-BIB0016|phy213655-cit-0016","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molimm.2013.04.009","article-title":"Complement activation is critical for placental ischemia-induced hypertension in the rat","volume":"56","author":"Lillegard","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.14814\/phy2.13655-BIB0017|phy213655-cit-0017","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1124\/jpet.114.218123","article-title":"Differential effects of complement activation products c3a and c5a on cardiovascular function in hypertensive pregnant rats","volume":"351","author":"Lillegard","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.14814\/phy2.13655-BIB0018|phy213655-cit-0018","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/HYPERTENSIONAHA.113.02637","article-title":"Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence","volume":"63","author":"Liu","year":"2014","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0019|phy213655-cit-0019","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.smim.2013.04.002","article-title":"Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis","volume":"25","author":"Mastellos","year":"2013","journal-title":"Semin. Immunol."},{"key":"10.14814\/phy2.13655-BIB0020|phy213655-cit-0020","doi-asserted-by":"crossref","first-page":"F499","DOI":"10.1152\/ajprenal.00258.2014","article-title":"Infiltrating immune cells in the kidney in salt-sensitive hypertension and renal injury","volume":"307","author":"Mattson","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.14814\/phy2.13655-BIB0021|phy213655-cit-0021","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.HYP.0000228320.23697.29","article-title":"Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat","volume":"48","author":"Mattson","year":"2006","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0022|phy213655-cit-0022","doi-asserted-by":"crossref","first-page":"F837","DOI":"10.1152\/ajprenal.90341.2008","article-title":"Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease","volume":"295","author":"Mattson","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.14814\/phy2.13655-BIB0023|phy213655-cit-0023","doi-asserted-by":"crossref","first-page":"R407","DOI":"10.1152\/ajpregu.00304.2012","article-title":"Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage","volume":"304","author":"Mattson","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13655-BIB0024|phy213655-cit-0024","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1681\/ASN.V114700","article-title":"Complement activation products in the urine from proteinuric patients","volume":"11","author":"Morita","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13655-BIB0025|phy213655-cit-0025","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/eci.12275","article-title":"C3 and C4 are strongly related to adipose tissue variables and\u00a0cardiovascular risk factors","volume":"44","author":"Nilsson","year":"2014","journal-title":"Eur. J. Clin. Invest."},{"key":"10.14814\/phy2.13655-BIB0026|phy213655-cit-0026","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2369-12-64","article-title":"Excretion of complement proteins and its activation marker C5b-9 in IgA nephropathy in relation to renal function","volume":"12","author":"Onda","year":"2011","journal-title":"BMC Nephrol."},{"key":"10.14814\/phy2.13655-BIB0027|phy213655-cit-0027","doi-asserted-by":"crossref","first-page":"R1234","DOI":"10.1152\/ajpregu.00821.2007","article-title":"Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure","volume":"294","author":"Pechman","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.14814\/phy2.13655-BIB0028|phy213655-cit-0028","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.4049\/jimmunol.152.11.5477","article-title":"Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis","volume":"152","author":"Piddlesden","year":"1994","journal-title":"J. Immunol."},{"key":"10.14814\/phy2.13655-BIB0029|phy213655-cit-0029","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-5728(96)00144-0","article-title":"Soluble complement receptor 1 (sCR1) protects against experimental autoimmune myasthenia gravis","volume":"71","author":"Piddlesden","year":"1996","journal-title":"J. Neuroimmunol."},{"key":"10.14814\/phy2.13655-BIB0030|phy213655-cit-0030","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.molimm.2009.09.019","article-title":"Complement inhibition accelerates regeneration in a model of peripheral nerve injury","volume":"47","author":"Ramaglia","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.14814\/phy2.13655-BIB0031|phy213655-cit-0031","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0022-3565(25)39575-3","article-title":"Role of the complement system in antigen-induced bronchoconstriction and changes in blood pressure in the guinea pig","volume":"267","author":"Regal","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.14814\/phy2.13655-BIB0032|phy213655-cit-0032","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2016.08.016","article-title":"Role of IgM and\u00a0angiotensin II Type I receptor autoantibodies in\u00a0local\u00a0complement activation in placental ischemia-induced hypertension in the rat","volume":"78","author":"Regal","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.14814\/phy2.13655-BIB0033|phy213655-cit-0033","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11906-017-0784-4","article-title":"The Complement System and Preeclampsia","volume":"19","author":"Regal","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.14814\/phy2.13655-BIB0034|phy213655-cit-0034","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrneph.2017.156","article-title":"The renaissance of complement therapeutics","volume":"14","author":"Ricklin","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.14814\/phy2.13655-BIB0035|phy213655-cit-0035","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.00031.2016","article-title":"Role of the Immune System in Hypertension","volume":"97","author":"Rodriguez-Iturbe","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.14814\/phy2.13655-BIB0036|phy213655-cit-0036","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1161\/ATVBAHA.110.215525","article-title":"Perivascular adipose tissue-derived complement 3 is required for adventitial fibroblast functions and adventitial remodeling in deoxycorticosterone acetate-salt hypertensive rats","volume":"30","author":"Ruan","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.14814\/phy2.13655-BIB0037|phy213655-cit-0037","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1161\/ATVBAHA.114.304927","article-title":"Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice","volume":"35","author":"Ruan","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.14814\/phy2.13655-BIB0038|phy213655-cit-0038","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/HYPERTENSIONAHA.113.02191","article-title":"CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney","volume":"63","author":"Rudemiller","year":"2014","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0039|phy213655-cit-0039","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/HYPERTENSIONAHA.114.04736","article-title":"Mutation of SH2B3 (LNK), a genome-wide association study candidate for\u00a0hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation","volume":"65","author":"Rudemiller","year":"2015","journal-title":"Hypertension"},{"key":"10.14814\/phy2.13655-BIB0040|phy213655-cit-0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01540956","article-title":"Relationships between antibodies against human soluble complement receptor 1 (hsCR1) from various species","volume":"16","author":"Ruggieri","year":"1996","journal-title":"J. Clin. Immunol."},{"key":"10.14814\/phy2.13655-BIB0041|phy213655-cit-0041","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0009-8981(95)06147-9","article-title":"Urinary C4 excretion in\u00a0systemic lupus erythematosus","volume":"243","author":"Ueda","year":"1995","journal-title":"Clin. Chim. Acta"},{"key":"10.14814\/phy2.13655-BIB0042|phy213655-cit-0042","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1681\/ASN.2013010045","article-title":"Soluble CR1 therapy improves complement regulation in C3 glomerulopathy","volume":"24","author":"Zhang","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13655-BIB0043|phy213655-cit-0043","doi-asserted-by":"crossref","first-page":"F957","DOI":"10.1152\/ajprenal.00344.2013","article-title":"Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice","volume":"305","author":"Zhou","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13655\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T09:40:24Z","timestamp":1751535624000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13655","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}