{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:19:47Z","timestamp":1770221987519,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-03904"],"award-info":[{"award-number":["RGPIN-2017-03904"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 2016-04300"],"award-info":[{"award-number":["RGPIN 2016-04300"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Foundation for Innovation","award":["222084"],"award-info":[{"award-number":["222084"]}]},{"name":"Ontario Graduate Student Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.14814\/phy2.13729","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T16:38:26Z","timestamp":1528735106000},"page":"e13729","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of neuropathological effects of a high-fat high-sucrose diet in middle-aged male C57BL6\/J mice"],"prefix":"10.14814","volume":"6","author":[{"given":"Bradley J.","family":"Baranowski","sequence":"first","affiliation":[{"name":"Department of Health Sciences; Brock University; Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten N.","family":"Bott","sequence":"additional","affiliation":[{"name":"Department of Health Sciences; Brock University; Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca E. K.","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences; Brock University; Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"10.14814\/phy2.13729-BIB0001|phy213729-cit-0001","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2007-995246","article-title":"Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection","volume":"66","author":"Behl","year":"1998","journal-title":"Fortschr. Neurol. Psychiatr."},{"key":"10.14814\/phy2.13729-BIB0002|phy213729-cit-0002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1750-1326-4-14","article-title":"The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events","volume":"4","author":"Bhaskar","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"10.14814\/phy2.13729-BIB0003|phy213729-cit-0003","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3233\/JAD-2012-121030","article-title":"Increased Tau phosphorylation and impaired brain insulin\/IGF signaling in mice fed a high fat\/high cholesterol diet","volume":"36","author":"Bhat","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.14814\/phy2.13729-BIB0005|phy213729-cit-0005","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1038\/nutd.2012.3","article-title":"Relation of depot-specific adipose inflammation to insulin resistance in human obesity","volume":"2","author":"Bigornia","year":"2012","journal-title":"Nutr. Diabetes"},{"key":"10.14814\/phy2.13729-BIB0006|phy213729-cit-0006","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700137","article-title":"Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL\/6J mice","volume":"61","author":"Bott","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.14814\/phy2.13729-BIB0007|phy213729-cit-0007","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.tibs.2004.03.006","article-title":"Advances in protein kinase B signalling: AKTion on multiple fronts","volume":"29","author":"Brazil","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.14814\/phy2.13729-BIB0008|phy213729-cit-0008","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/oby.2007.608","article-title":"High-fat diets: modeling the metabolic disorders of human obesity in rodents","volume":"15","author":"Buettner","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"10.14814\/phy2.13729-BIB0010|phy213729-cit-0010","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/iub.1098","article-title":"The impairment of insulin signaling in Alzheimer's disease","volume":"64","author":"Candeias","year":"2012","journal-title":"IUBMB Life"},{"key":"10.14814\/phy2.13729-BIB0011|phy213729-cit-0011","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.14814\/phy2.13729-BIB0012|phy213729-cit-0012","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1073\/pnas.0807991106","article-title":"Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.14814\/phy2.13729-BIB0013|phy213729-cit-0013","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.nbd.2008.12.014","article-title":"JNK regulates APP cleavage and degradation in a model of Alzheimer's disease","volume":"33","author":"Colombo","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.14814\/phy2.13729-BIB0014|phy213729-cit-0014","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1523\/JNEUROSCI.20-12-04563.2000","article-title":"The MAPK\/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in\u00a0vivo","volume":"20","author":"Davis","year":"2000","journal-title":"J. Neurosci."},{"key":"10.14814\/phy2.13729-BIB0015|phy213729-cit-0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1101\/lm.88005","article-title":"Insulin receptor signaling in long-term memory consolidation following spatial learning","volume":"12","author":"Dou","year":"2005","journal-title":"Learn Mem."},{"key":"10.14814\/phy2.13729-BIB0018|phy213729-cit-0018","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s007020100016","article-title":"Phosphorylated mitogen-activated protein kinase (MAPK\/ERK-P), protein kinase of 38\u00a0kDa (p38-P), stress-activated protein kinase (SAPK\/JNK-P), and calcium\/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies","volume":"108","author":"Ferrer","year":"2001a","journal-title":"J. Neural. Transm (Vienna)"},{"key":"10.14814\/phy2.13729-BIB0019|phy213729-cit-0019","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1750-3639.2001.tb00387.x","article-title":"Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration","volume":"11","author":"Ferrer","year":"2001b","journal-title":"Brain Pathol."},{"key":"10.14814\/phy2.13729-BIB0020|phy213729-cit-0020","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in obesity among adults in the United States, 2005 to 2014","volume":"315","author":"Flegal","year":"2016","journal-title":"JAMA"},{"key":"10.14814\/phy2.13729-BIB0021|phy213729-cit-0021","first-page":"1121","article-title":"The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease","volume":"115","author":"Gandy","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.14814\/phy2.13729-BIB0022|phy213729-cit-0022","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.neurobiolaging.2005.05.022","article-title":"Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease","volume":"26","author":"Gouras","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.14814\/phy2.13729-BIB0023|phy213729-cit-0023","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1471-4159.2004.02949.x","article-title":"Activation of Akt\/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology","volume":"93","author":"Griffin","year":"2005","journal-title":"J. Neurochem."},{"key":"10.14814\/phy2.13729-BIB0025|phy213729-cit-0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/00365510701864610","article-title":"Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease","volume":"69","author":"Hampel","year":"2009","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.14814\/phy2.13729-BIB0026|phy213729-cit-0026","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1046\/j.1471-4159.2003.01585.x","article-title":"Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death","volume":"84","author":"Hashimoto","year":"2003","journal-title":"J. Neurochem."},{"key":"10.14814\/phy2.13729-BIB0028|phy213729-cit-0028","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1046\/j.1471-4159.1999.0722053.x","article-title":"p38 kinase is activated in the Alzheimer's disease brain","volume":"72","author":"Hensley","year":"1999","journal-title":"J. Neurochem."},{"key":"10.14814\/phy2.13729-BIB0030|phy213729-cit-0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1600-0447.1987.tb02906.x","article-title":"The prevalence of dementia: a quantitative integration of the literature","volume":"76","author":"Jorm","year":"1987","journal-title":"Acta Psychiatr. Scand."},{"key":"10.14814\/phy2.13729-BIB0031|phy213729-cit-0031","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"10.14814\/phy2.13729-BIB0032|phy213729-cit-0032","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","article-title":"Pathological roles of MAPK signaling pathways in human diseases","volume":"1802","author":"Kim","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.14814\/phy2.13729-BIB0034|phy213729-cit-0034","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.bbadis.2016.10.006","article-title":"High fat diet induces brain insulin resistance and cognitive impairment in mice","volume":"1863","author":"Kothari","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.14814\/phy2.13729-BIB0035|phy213729-cit-0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/JAD-2006-9102","article-title":"Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease","volume":"9","author":"Lester-Coll","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.14814\/phy2.13729-BIB0036|phy213729-cit-0036","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/db07-0171","article-title":"Alzheimer-like changes in rat models of spontaneous diabetes","volume":"56","author":"Li","year":"2007","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13729-BIB0037|phy213729-cit-0037","doi-asserted-by":"crossref","first-page":"12230","DOI":"10.1523\/JNEUROSCI.1694-14.2014","article-title":"Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid beta","volume":"34","author":"Ma","year":"2014","journal-title":"J. Neurosci."},{"key":"10.14814\/phy2.13729-BIB0038|phy213729-cit-0038","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/japplphysiol.00299.2015","article-title":"Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice","volume":"119","author":"Macpherson","year":"2015","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"1011","key":"10.14814\/phy2.13729-BIB0039|phy213729-cit-0039","first-page":"e11","article-title":"Environmental enrichment ameliorated high-fat diet-induced Abeta deposition and memory deficit in APP transgenic mice","volume":"33","author":"Maesako","year":"2012a","journal-title":"Neurobiol. Aging"},{"key":"10.14814\/phy2.13729-BIB0040|phy213729-cit-0040","doi-asserted-by":"crossref","first-page":"23024","DOI":"10.1074\/jbc.M112.367011","article-title":"Exercise is more effective than diet control in preventing high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice","volume":"287","author":"Maesako","year":"2012b","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.13729-BIB0041|phy213729-cit-0041","doi-asserted-by":"crossref","first-page":"e72796","DOI":"10.1371\/journal.pone.0072796","article-title":"Continuation of exercise is necessary to inhibit high fat diet-induced beta-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice","volume":"8","author":"Maesako","year":"2013","journal-title":"PLoS ONE"},{"key":"10.14814\/phy2.13729-BIB0043|phy213729-cit-0043","doi-asserted-by":"crossref","first-page":"28294","DOI":"10.1074\/jbc.M212265200","article-title":"Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway","volume":"278","author":"Marques","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.13729-BIB0044|phy213729-cit-0044","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/s11064-007-9530-7","article-title":"Different effect of high fat diet and physical exercise in the hippocampal signaling","volume":"33","author":"Muller","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.14814\/phy2.13729-BIB0045|phy213729-cit-0045","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1091\/mbc.e06-07-0625","article-title":"The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration","volume":"18","author":"Muresan","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.14814\/phy2.13729-BIB0046|phy213729-cit-0046","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fnins.2014.00375","article-title":"Obesity and cognitive decline: role of inflammation and vascular changes","volume":"8","author":"Nguyen","year":"2014","journal-title":"Front Neurosci."},{"key":"10.14814\/phy2.13729-BIB0047|phy213729-cit-0047","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12603-015-0601-1","article-title":"A high-sugar high-fat diet induced metabolic syndrome shows some symptoms of Alzheimer's Disease in rats","volume":"20","author":"Niu","year":"2016","journal-title":"J. Nutr. Health Aging"},{"key":"10.14814\/phy2.13729-BIB0049|phy213729-cit-0049","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00401-002-0657-y","article-title":"Role of protein kinase B in Alzheimer's neurofibrillary pathology","volume":"105","author":"Pei","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.14814\/phy2.13729-BIB0050|phy213729-cit-0050","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1097\/00001756-199908020-00035","article-title":"Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation","volume":"10","author":"Perry","year":"1999","journal-title":"NeuroReport"},{"key":"10.14814\/phy2.13729-BIB0052|phy213729-cit-0052","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-2990.2004.00569.x","article-title":"Expression of stress-activated kinases c-Jun N-terminal kinase (SAPK\/JNK-P) and p38 kinase (p38-P), and tau hyperphosphorylation in neurites surrounding betaA plaques in APP Tg2576 mice","volume":"30","author":"Puig","year":"2004","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.14814\/phy2.13729-BIB0053|phy213729-cit-0053","doi-asserted-by":"crossref","first-page":"e30378","DOI":"10.1371\/journal.pone.0030378","article-title":"Amyloid precursor protein and proinflammatory changes are regulated in brain and adipose tissue in a murine model of high fat diet-induced obesity","volume":"7","author":"Puig","year":"2012","journal-title":"PLoS ONE"},{"key":"10.14814\/phy2.13729-BIB0054|phy213729-cit-0054","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2007.01.008","article-title":"Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis","volume":"5","author":"Reznick","year":"2007","journal-title":"Cell Metab."},{"key":"10.14814\/phy2.13729-BIB0055|phy213729-cit-0055","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00001756-200404290-00005","article-title":"Akt activity in Alzheimer's disease and other neurodegenerative disorders","volume":"15","author":"Rickle","year":"2004","journal-title":"NeuroReport"},{"key":"10.14814\/phy2.13729-BIB0056|phy213729-cit-0056","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/JAD-2001-3111","article-title":"Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein","volume":"3","author":"Selkoe","year":"2001","journal-title":"J. Alzheimers Dis."},{"key":"10.14814\/phy2.13729-BIB0057|phy213729-cit-0057","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/ncb1104-1054","article-title":"Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases","volume":"6","author":"Selkoe","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.14814\/phy2.13729-BIB0058|phy213729-cit-0058","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0169-328X(00)00245-X","article-title":"JNK activation is associated with intracellular beta-amyloid accumulation","volume":"85","author":"Shoji","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.14814\/phy2.13729-BIB0059|phy213729-cit-0059","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jneuroim.2014.06.004","article-title":"Inflammation and insulin\/IGF-1 resistance as the possible link between obesity and neurodegeneration","volume":"273","author":"Spielman","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.14814\/phy2.13729-BIB0060|phy213729-cit-0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-61779-111-6_2","article-title":"Dissection of rodent brain regions","volume":"57","author":"Spijker","year":"2011","journal-title":"Neuroproteomics, Neuromethods"},{"key":"10.14814\/phy2.13729-BIB0061|phy213729-cit-0061","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3892\/ijmm.2017.2962","article-title":"The extracellular signal-regulated kinase 1\/2 pathway in neurological diseases: A potential therapeutic target (Review)","volume":"39","author":"Sun","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.14814\/phy2.13729-BIB0063|phy213729-cit-0063","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.neurobiolaging.2007.12.015","article-title":"JNK and ERK1\/2 pathways have a dual opposite effect on the expression of BACE1","volume":"30","author":"Tamagno","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.14814\/phy2.13729-BIB0064|phy213729-cit-0064","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1471-4159.2008.05415.x","article-title":"High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice","volume":"106","author":"Thirumangalakudi","year":"2008","journal-title":"J. Neurochem."},{"key":"10.14814\/phy2.13729-BIB0065|phy213729-cit-0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.RES.0000156076.17807.1F","article-title":"Another role for the celebrity: Akt and insulin resistance","volume":"96","author":"Tian","year":"2005","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13729-BIB0066|phy213729-cit-0066","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/jnnp.2006.110361","article-title":"Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study","volume":"78","author":"Verdelho","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.14814\/phy2.13729-BIB0067|phy213729-cit-0067","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-010-0759-x","article-title":"AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies","volume":"121","author":"Vingtdeux","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.14814\/phy2.13729-BIB0068|phy213729-cit-0068","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.neuroscience.2009.04.032","article-title":"Exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation and beta-amyloid generation in rat brains","volume":"161","author":"Zhang","year":"2009","journal-title":"Neuroscience"},{"key":"10.14814\/phy2.13729-BIB0069|phy213729-cit-0069","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1096\/fj.06-7703com","article-title":"Amyloid beta oligomers induce impairment of neuronal insulin receptors","volume":"22","author":"Zhao","year":"2008","journal-title":"FASEB J."},{"key":"10.14814\/phy2.13729-BIB0070|phy213729-cit-0070","doi-asserted-by":"crossref","first-page":"B539","DOI":"10.1093\/gerona\/54.12.B539","article-title":"Age-associated impairment in brain MAPK signal pathways and the effect of caloric restriction in Fischer 344 rats","volume":"54","author":"Zhen","year":"1999","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.14814\/phy2.13729-BIB0071|phy213729-cit-0071","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/jnen\/59.10.880","article-title":"Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease","volume":"59","author":"Zhu","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.14814\/phy2.13729-BIB0072|phy213729-cit-0072","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0047-6374(01)00342-6","article-title":"Differential activation of neuronal ERK, JNK\/SAPK and p38 in Alzheimer disease: the \u2018two hit\u2019 hypothesis","volume":"123","author":"Zhu","year":"2001a","journal-title":"Mech. Ageing Dev."},{"key":"10.14814\/phy2.13729-BIB0073|phy213729-cit-0073","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1471-4159.2001.00046.x","article-title":"Activation and redistribution of c-jun N-terminal kinase\/stress activated protein kinase in degenerating neurons in Alzheimer's disease","volume":"76","author":"Zhu","year":"2001b","journal-title":"J. Neurochem."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13729","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13729\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T09:58:20Z","timestamp":1604397500000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13729","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}