{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:20Z","timestamp":1787022380187,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sapporo Medical University","award":["2016-2017"],"award-info":[{"award-number":["2016-2017"]}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.14814\/phy2.13741","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T11:44:24Z","timestamp":1529667864000},"page":"e13741","source":"Crossref","is-referenced-by-count":147,"title":["Empagliflozin normalizes the size and number of mitochondria and prevents reduction in mitochondrial size after myocardial infarction in diabetic hearts"],"prefix":"10.14814","volume":"6","author":[{"given":"Masashi","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"},{"name":"Department of Pharmacology; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Oshima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"},{"name":"Department of Cellular Physiology and Signal Transduction; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukishige","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Tanno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Renal and Metabolic Medicine; Sapporo Medical University School of Medicine; Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"10.14814\/phy2.13741-BIB0001|phy213741-cit-0001","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1113\/jphysiol.2008.163311","article-title":"Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes","volume":"587","author":"Barba","year":"2009","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.13741-BIB0002|phy213741-cit-0002","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/cvr\/cvx149","article-title":"Cardiac effects of SGLT2 inhibitors: the sodium hypothesis","volume":"114","author":"Bertero","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.14814\/phy2.13741-BIB0003|phy213741-cit-0003","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2337\/db07-0481","article-title":"Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins","volume":"56","author":"Boudina","year":"2007","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13741-BIB0004|phy213741-cit-0004","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/cvr\/cvq239","article-title":"Mitochondria in the diabetic heart","volume":"88","author":"Bugger","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.14814\/phy2.13741-BIB0005|phy213741-cit-0005","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.2337\/db08-0079","article-title":"Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3","volume":"57","author":"Bugger","year":"2008","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13741-BIB0006|phy213741-cit-0006","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1475-2840-13-28","article-title":"The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus","volume":"13","author":"Cherney","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.14814\/phy2.13741-BIB0007|phy213741-cit-0007","doi-asserted-by":"crossref","first-page":"H359","DOI":"10.1152\/ajpheart.00467.2008","article-title":"Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations","volume":"296","author":"Dabkowski","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.13741-BIB0008|phy213741-cit-0008","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2337\/dc12-1507","article-title":"Impact of diabetes on long-term outcome after primary angioplasty: insights from the DESERT cooperation","volume":"36","author":"Luca","year":"2013","journal-title":"Diabetes Care"},{"key":"10.14814\/phy2.13741-BIB0009|phy213741-cit-0009","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.gde.2016.03.001","article-title":"Mitochondrial fission\/fusion and cardiomyopathy","volume":"38","author":"Dorn","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.14814\/phy2.13741-BIB0010|phy213741-cit-0010","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1172\/JCI72227","article-title":"Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients","volume":"124","author":"Ferrannini","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.14814\/phy2.13741-BIB0011|phy213741-cit-0011","doi-asserted-by":"crossref","first-page":"H1075","DOI":"10.1152\/ajpheart.00945.2015","article-title":"Reduced mitochondrial respiration in the ischemic as well as in the remote nonischemic region in postmyocardial infarction remodeling","volume":"311","author":"Galan","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.13741-BIB0012|phy213741-cit-0012","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1085\/jgp.201210771","article-title":"Perspectives on: SGP symposium on mitochondrial physiology and medicine: what comes first, misshape or dysfunction? The view from metabolic excess","volume":"139","author":"Galloway","year":"2012","journal-title":"J. Gen. Physiol."},{"key":"10.14814\/phy2.13741-BIB0013|phy213741-cit-0013","doi-asserted-by":"crossref","first-page":"H853","DOI":"10.1152\/ajpheart.00154.2012","article-title":"Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats","volume":"303","author":"Guglielmino","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.13741-BIB0014|phy213741-cit-0014","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12933-016-0489-z","article-title":"Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes","volume":"16","author":"Habibi","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.14814\/phy2.13741-BIB0015|phy213741-cit-0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10557-017-6734-1","article-title":"Empagliflozin improves left ventricular diastolic dysfunction in a genetic model of type 2 diabetes","volume":"31","author":"Hammoudi","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.14814\/phy2.13741-BIB0016|phy213741-cit-0016","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00005344-200306000-00014","article-title":"Efficacy of edaravone, a free radical scavenger, on left ventricular function and structure in diabetes mellitus","volume":"41","author":"Hayashi","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.14814\/phy2.13741-BIB0017|phy213741-cit-0017","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00005344-198806000-00011","article-title":"Evolving myocardial infarction in the rat in\u00a0vivo: an inappropriate model for the investigation of drug-induced infarct size limitation during sustained regional ischaemia","volume":"11","author":"Hearse","year":"1988","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.14814\/phy2.13741-BIB0018|phy213741-cit-0018","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/CIRCRESAHA.109.205385","article-title":"Angiotensin II type 1 receptor-mediated upregulation of calcineurin activity underlies impairment of cardioprotective signaling in diabetic hearts","volume":"106","author":"Hotta","year":"2010","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13741-BIB0019|phy213741-cit-0019","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/15548627.2016.1166318","article-title":"Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways","volume":"12","author":"Huang","year":"2016","journal-title":"Autophagy"},{"key":"10.14814\/phy2.13741-BIB0020|phy213741-cit-0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.RES.88.5.529","article-title":"Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction","volume":"88","author":"Ide","year":"2001","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13741-BIB0021|phy213741-cit-0021","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.2337\/dc17-0518","article-title":"Comparison of ipragliflozin and pioglitazone effects on nonalcoholic fatty liver disease in patients with type 2 diabetes: a randomized, 24-week, open-label, active-controlled trial","volume":"40","author":"Ito","year":"2017","journal-title":"Diabetes Care"},{"key":"10.14814\/phy2.13741-BIB0022|phy213741-cit-0022","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3390\/antiox7010013","article-title":"Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression","volume":"7","author":"Jezek","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"10.14814\/phy2.13741-BIB0023|phy213741-cit-0023","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.2337\/db16-0733","article-title":"The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model","volume":"66","author":"Joubert","year":"2017","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13741-BIB0024|phy213741-cit-0024","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.yjmcc.2015.01.004","article-title":"Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart","volume":"80","author":"Kouzu","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.14814\/phy2.13741-BIB0025|phy213741-cit-0025","doi-asserted-by":"crossref","first-page":"23852","DOI":"10.1074\/jbc.M111.328708","article-title":"Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation","volume":"287","author":"Kuramoto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.13741-BIB0026|phy213741-cit-0026","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ehjcvp\/pvw009","article-title":"Sodium-glucose cotransporter 2 inhibition: cardioprotection by treating diabetes-a translational viewpoint explaining its potential salutary effects","volume":"2","author":"Leeuw","year":"2016","journal-title":"Eur. Heart J. Cardiovasc Pharmacother."},{"key":"10.14814\/phy2.13741-BIB0027|phy213741-cit-0027","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00030.2008","article-title":"Mitochondrial dynamics in mammalian health and disease","volume":"89","author":"Liesa","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.14814\/phy2.13741-BIB0028|phy213741-cit-0028","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.14814\/phy2.13741-BIB0029|phy213741-cit-0029","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","article-title":"Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission","volume":"24","author":"Loson","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.14814\/phy2.13741-BIB0030|phy213741-cit-0030","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI65268","article-title":"Diabetes increases mortality after myocardial infarction by oxidizing CaMKII","volume":"123","author":"Luo","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.14814\/phy2.13741-BIB0031|phy213741-cit-0031","doi-asserted-by":"crossref","first-page":"C246","DOI":"10.1152\/ajpcell.00294.2010","article-title":"Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: evidence that mitochondrial dysfunction begins in the subepicardium","volume":"300","author":"MacDonald","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.14814\/phy2.13741-BIB0032|phy213741-cit-0032","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1242\/jcs.159186","article-title":"OPA1 processing in cell death and disease - the long and short of it","volume":"129","author":"MacVicar","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.14814\/phy2.13741-BIB0033|phy213741-cit-0033","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.amjcard.2007.02.080","article-title":"Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)","volume":"100","author":"Marso","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"10.14814\/phy2.13741-BIB0034|phy213741-cit-0034","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/cvr\/21.10.737","article-title":"Species variation in the coronary collateral circulation during regional myocardial ischaemia: a critical determinant of the rate of evolution and extent of myocardial infarction","volume":"21","author":"Maxwell","year":"1987","journal-title":"Cardiovasc. Res."},{"key":"10.14814\/phy2.13741-BIB0035|phy213741-cit-0035","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bcp.2010.01.019","article-title":"Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase","volume":"79","author":"Mellor","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.14814\/phy2.13741-BIB0036|phy213741-cit-0036","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.2337\/db09-0158","article-title":"Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition","volume":"58","author":"Miki","year":"2009","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13741-BIB0037|phy213741-cit-0037","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1247\/csf.27.421","article-title":"Autophagosome formation in mammalian cells","volume":"27","author":"Mizushima","year":"2002","journal-title":"Cell Struct. Funct."},{"key":"10.14814\/phy2.13741-BIB0038|phy213741-cit-0038","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/CIRCULATIONAHA.113.008476","article-title":"Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients","volume":"130","author":"Montaigne","year":"2014","journal-title":"Circulation"},{"key":"10.14814\/phy2.13741-BIB0039|phy213741-cit-0039","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.2337\/dc16-0542","article-title":"Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME Study? a unifying hypothesis","volume":"39","author":"Mudaliar","year":"2016","journal-title":"Diabetes Care"},{"key":"10.14814\/phy2.13741-BIB0040|phy213741-cit-0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12933-015-0264-6","article-title":"Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats","volume":"14","author":"Murase","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.14814\/phy2.13741-BIB0041|phy213741-cit-0041","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1038\/s41598-017-05667-5","article-title":"Suppressed autophagic response underlies augmentation of renal ischemia\/reperfusion injury by type 2 diabetes","volume":"7","author":"Muratsubaki","year":"2017","journal-title":"Sci. Rep."},{"key":"10.14814\/phy2.13741-BIB0042|phy213741-cit-0042","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.14814\/phy2.13741-BIB0043|phy213741-cit-0043","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.tcb.2016.05.008","article-title":"Deciphering the molecular signals of PINK1\/Parkin mitophagy","volume":"26","author":"Nguyen","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.14814\/phy2.13741-BIB0044|phy213741-cit-0044","doi-asserted-by":"crossref","first-page":"e112394","DOI":"10.1371\/journal.pone.0112394","article-title":"The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity","volume":"9","author":"Oelze","year":"2014","journal-title":"PLoS ONE"},{"issue":"Supple I","key":"10.14814\/phy2.13741-BIB0045|phy213741-cit-0045","first-page":"S32","article-title":"Empagliflozin, an SGLT2 inhibitor, improves survival after myocardial infarction in diabetic rats by up-regulating anti-oxidative stress proteins","volume":"60","author":"Oshima","year":"2017","journal-title":"Diabetologia"},{"key":"10.14814\/phy2.13741-BIB0046|phy213741-cit-0046","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1152\/japplphysiol.00873.2014","article-title":"Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm","volume":"118","author":"Picard","year":"2015","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.14814\/phy2.13741-BIB0047|phy213741-cit-0047","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1038\/ncomms11124","article-title":"Early ERK1\/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming","volume":"7","author":"Prieto","year":"2016","journal-title":"Nat. Commun."},{"key":"10.14814\/phy2.13741-BIB0048|phy213741-cit-0048","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1091\/mbc.e10-06-0551","article-title":"Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in\u00a0vivo","volume":"22","author":"Qi","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.14814\/phy2.13741-BIB0049|phy213741-cit-0049","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCRESAHA.116.306842","article-title":"Lipid Use and Misuse by the Heart","volume":"118","author":"Schulze","year":"2016","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13741-BIB0050|phy213741-cit-0050","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1161\/CIRCULATIONAHA.110.014506","article-title":"Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus","volume":"124","author":"Shenouda","year":"2011","journal-title":"Circulation"},{"key":"10.14814\/phy2.13741-BIB0051|phy213741-cit-0051","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.115.020502","article-title":"Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure","volume":"133","author":"Shirakabe","year":"2016","journal-title":"Circulation"},{"key":"10.14814\/phy2.13741-BIB0052|phy213741-cit-0052","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.yjmcc.2012.01.021","article-title":"MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction","volume":"52","author":"Singh","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.14814\/phy2.13741-BIB0053|phy213741-cit-0053","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1038\/nutd.2014.20","article-title":"Tofogliflozin, a sodium\/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models","volume":"4","author":"Suzuki","year":"2014","journal-title":"Nutr. Diabetes"},{"key":"10.14814\/phy2.13741-BIB0054|phy213741-cit-0054","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1074\/jbc.M607279200","article-title":"Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission","volume":"282","author":"Taguchi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.13741-BIB0055|phy213741-cit-0055","doi-asserted-by":"crossref","first-page":"e39893","DOI":"10.1371\/journal.pone.0039893","article-title":"Role of ER stress in ventricular contractile dysfunction in type 2 diabetes","volume":"7","author":"Takada","year":"2012","journal-title":"PLoS ONE"},{"key":"10.14814\/phy2.13741-BIB0056|phy213741-cit-0056","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1530\/JOE-17-0457","article-title":"Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury","volume":"236","author":"Tanajak","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.14814\/phy2.13741-BIB0057|phy213741-cit-0057","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCRESAHA.117.311307","article-title":"Mitochondrial reactive oxygen species in lipotoxic hearts induce post-translational modifications of AKAP121, DRP1, and OPA1 that promote mitochondrial fission","volume":"122","author":"Tsushima","year":"2017","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13741-BIB0058|phy213741-cit-0058","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.yjmcc.2017.06.003","article-title":"LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy","volume":"108","author":"Xia","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.14814\/phy2.13741-BIB0059|phy213741-cit-0059","doi-asserted-by":"crossref","first-page":"13189","DOI":"10.1038\/ncomms13189","article-title":"CaMKII induces permeability transition through Drp1 phosphorylation during chronic beta-AR stimulation","volume":"7","author":"Xu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.14814\/phy2.13741-BIB0060|phy213741-cit-0060","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejphar.2014.01.040","article-title":"SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats","volume":"727","author":"Yokono","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.14814\/phy2.13741-BIB0500|phy213741-cit-0500","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1074\/jbc.M112.399345","article-title":"Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis","volume":"288","author":"Zhu","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.14814\/phy2.13741-BIB0061|phy213741-cit-0061","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N. Engl. J. Med."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13741\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T21:51:58Z","timestamp":1530136318000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13741","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}