{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:21Z","timestamp":1787022381421,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DolCas Biotech, LLC, Fort Valley"},{"name":"Arjuna Natural, Irving, TX, USA"},{"name":"VA-Merit Grant","award":["I01BX003271-01"],"award-info":[{"award-number":["I01BX003271-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.14814\/phy2.13789","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T04:42:26Z","timestamp":1531716146000},"page":"e13789","source":"Crossref","is-referenced-by-count":44,"title":["Curcumin supplementation mitigates NASH development and progression in female Wistar rats"],"prefix":"10.14814","volume":"6","author":[{"given":"Rory P.","family":"Cunningham","sequence":"first","affiliation":[{"name":"Research Service-Harry S Truman Memorial VA Hospital; Columbia Missouri"},{"name":"Department of Nutrition and Exercise Physiology; University of Missouri; Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary P.","family":"Moore","sequence":"additional","affiliation":[{"name":"Research Service-Harry S Truman Memorial VA Hospital; Columbia Missouri"},{"name":"Department of Nutrition and Exercise Physiology; University of Missouri; Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique N.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; Edward Via College of Osteopathic Medicine - Auburn Campus; Auburn Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Healy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; Edward Via College of Osteopathic Medicine - Auburn Campus; Auburn Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; Edward Via College of Osteopathic Medicine - Auburn Campus; Auburn Alabama"},{"name":"School of Kinesiology; Auburn University; Auburn Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Scott","family":"Rector","sequence":"additional","affiliation":[{"name":"Research Service-Harry S Truman Memorial VA Hospital; Columbia Missouri"},{"name":"Department of Nutrition and Exercise Physiology; University of Missouri; Columbia Missouri"},{"name":"Department of Medicine-GI; University of Missouri; Columbia Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-086X","authenticated-orcid":false,"given":"Jeffrey S.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences; Edward Via College of Osteopathic Medicine - Auburn Campus; Auburn Alabama"},{"name":"School of Kinesiology; Auburn University; Auburn Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"10.14814\/phy2.13789-BIB0001|phy213789-cit-0001","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1515\/znc-2001-7-826","article-title":"Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites","volume":"56","author":"Boll","year":"2001","journal-title":"Z. Naturforsch."},{"key":"10.14814\/phy2.13789-BIB0002|phy213789-cit-0002","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3748\/wjg.v18.i8.727","article-title":"Role of cytokines and chemokines in non-alcoholic fatty liver disease","volume":"18","author":"Braunersreuther","year":"2012","journal-title":"WJG"},{"key":"10.14814\/phy2.13789-BIB0003|phy213789-cit-0003","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J. Clin. Investig."},{"key":"10.14814\/phy2.13789-BIB0004|phy213789-cit-0004","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrgastro.2010.21","article-title":"Pathology of nonalcoholic fatty liver disease","volume":"7","author":"Brunt","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.14814\/phy2.13789-BIB0005|phy213789-cit-0005","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"10.14814\/phy2.13789-BIB0006|phy213789-cit-0006","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.25762","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association","volume":"55","author":"Chalasani","year":"2012","journal-title":"Hepatology"},{"key":"10.14814\/phy2.13789-BIB0007|phy213789-cit-0007","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1053\/jhep.2002.32527","article-title":"Apolipoprotein synthesis in nonalcoholic steatohepatitis","volume":"35","author":"Charlton","year":"2002","journal-title":"Hepatology"},{"key":"10.14814\/phy2.13789-BIB0008|phy213789-cit-0008","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.2337\/db10-0193","article-title":"Obesity is a fibroblast growth factor 21 (FGF21)-resistant state","volume":"59","author":"Chui","year":"2010","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13789-BIB0009|phy213789-cit-0009","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1053\/j.gastro.2010.04.054","article-title":"Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease","volume":"139","author":"Dushay","year":"2010","journal-title":"Gastroenterology"},{"key":"10.14814\/phy2.13789-BIB0010|phy213789-cit-0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1124\/mol.107.039818","article-title":"Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation","volume":"73","author":"Fu","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.14814\/phy2.13789-BIB0011|phy213789-cit-0011","first-page":"1","article-title":"Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research","volume":"14","author":"Jurenka","year":"2009","journal-title":"Altern. Med. Rev."},{"key":"10.14814\/phy2.13789-BIB0012|phy213789-cit-0012","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2249.2006.03108.x","article-title":"Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents","volume":"145","author":"Kaur","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.14814\/phy2.13789-BIB0013|phy213789-cit-0013","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cmet.2017.07.009","article-title":"Acetyl CoA carboxylase inhibition reduces hepatic steatosis but elevates plasma triglycerides in mice and humans: a bedside to bench investigation","volume":"26","author":"Kim","year":"2017","journal-title":"Cell Metab."},{"key":"10.14814\/phy2.13789-BIB0014|phy213789-cit-0014","first-page":"57","article-title":"Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis","volume":"34","author":"Koruk","year":"2004","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.14814\/phy2.13789-BIB0015|phy213789-cit-0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-7075-4-8","article-title":"Effects of curcumin on retinal oxidative stress and inflammation in diabetes","volume":"4","author":"Kowluru","year":"2007","journal-title":"Nutr. Metab."},{"key":"10.14814\/phy2.13789-BIB0016|phy213789-cit-0016","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.2337\/db08-0144","article-title":"Impact of oxidative stress and peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 in hepatic insulin resistance","volume":"57","author":"Kumashiro","year":"2008","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13789-BIB0017|phy213789-cit-0017","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jhep.2004.08.010","article-title":"Curcumin inhibits NF-\u03baB activation and reduces the severity of experimental steatohepatitis in mice","volume":"41","author":"Leclercq","year":"2004","journal-title":"J. Hepatol."},{"key":"10.14814\/phy2.13789-BIB0018|phy213789-cit-0018","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1038\/s41598-017-06872-y","article-title":"Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.14814\/phy2.13789-BIB0019|phy213789-cit-0019","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NF\u03baB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.14814\/phy2.13789-BIB0020|phy213789-cit-0020","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2010.05.018","article-title":"Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride","volume":"53","author":"Li","year":"2010","journal-title":"J. Hepatol."},{"key":"10.14814\/phy2.13789-BIB0021|phy213789-cit-0021","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/hep.23524","article-title":"Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats","volume":"51","author":"Li","year":"2010","journal-title":"Hepatology"},{"key":"10.14814\/phy2.13789-BIB0022|phy213789-cit-0022","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.2337\/db14-0541","article-title":"FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting","volume":"63","author":"Liang","year":"2014","journal-title":"Diabetes"},{"key":"10.14814\/phy2.13789-BIB0023|phy213789-cit-0023","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/ajcn\/79.3.502","article-title":"Model of nonalcoholic steatohepatitis","volume":"79","author":"Lieber","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.14814\/phy2.13789-BIB0024|phy213789-cit-0024","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jhep.2006.03.005","article-title":"\u2018Endocrine NAFLD'a hormonocentric perspective of nonalcoholic fatty liver disease pathogenesis","volume":"44","author":"Lonardo","year":"2006","journal-title":"J. Hepatol."},{"key":"10.14814\/phy2.13789-BIB0025|phy213789-cit-0025","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.dld.2015.08.004","article-title":"Epidemiological modifiers of non-alcoholic fatty liver disease: focus on high-risk groups","volume":"47","author":"Lonardo","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"10.14814\/phy2.13789-BIB0026|phy213789-cit-0026","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00109-009-0464-1","article-title":"Molecular mechanisms involved in NAFLD progression","volume":"87","author":"Malaguarnera","year":"2009","journal-title":"J. Mol. Med."},{"key":"10.14814\/phy2.13789-BIB0027|phy213789-cit-0027","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/labinvest.2008.91","article-title":"Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice","volume":"88","author":"Palacios","year":"2008","journal-title":"Lab. Invest."},{"key":"10.14814\/phy2.13789-BIB0028|phy213789-cit-0028","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/13813450802033958","article-title":"Role of curcumin in health and disease","volume":"114","author":"Pari","year":"2008","journal-title":"Arch. Physiol. Biochem."},{"key":"10.14814\/phy2.13789-BIB0029|phy213789-cit-0029","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1211\/0022357001774048","article-title":"Protective effect of curcumin in rat liver injury induced by carbon tetrachloride","volume":"52","author":"Park","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.14814\/phy2.13789-BIB0030|phy213789-cit-0030","doi-asserted-by":"crossref","first-page":"E1420","DOI":"10.1152\/ajpendo.00362.2009","article-title":"Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis","volume":"297","author":"Preitner","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.14814\/phy2.13789-BIB0031|phy213789-cit-0031","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.freeradbiomed.2009.06.015","article-title":"Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-\u03b1","volume":"47","author":"Ramirez-Tortosa","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.14814\/phy2.13789-BIB0032|phy213789-cit-0032","doi-asserted-by":"crossref","first-page":"G619","DOI":"10.1152\/ajpgi.00428.2007","article-title":"Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in otsuka long-evans tokushima fatty rats","volume":"294","author":"Rector","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.14814\/phy2.13789-BIB0033|phy213789-cit-0033","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1472-8206.2008.00611.x","article-title":"Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-\u03b2 modulation and oxidative stress","volume":"22","author":"Reyes-Gordillo","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.14814\/phy2.13789-BIB0034|phy213789-cit-0034","doi-asserted-by":"crossref","first-page":"G264","DOI":"10.1152\/ajpgi.00002.2004","article-title":"Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model","volume":"287","author":"Sahai","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.14814\/phy2.13789-BIB0035|phy213789-cit-0035","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.14814\/phy2.13789-BIB0036|phy213789-cit-0036","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1007\/s10620-013-2743-5","article-title":"Predictors of all-cause mortality and liver-related mortality in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"58","author":"Stepanova","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"10.14814\/phy2.13789-BIB0037|phy213789-cit-0037","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00125-008-1135-4","article-title":"Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?","volume":"51","author":"Targher","year":"2008","journal-title":"Diabetologia"},{"key":"10.14814\/phy2.13789-BIB0038|phy213789-cit-0038","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.14814\/phy2.13789-BIB0039|phy213789-cit-0039","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults","volume":"34","author":"Vernon","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.14814\/phy2.13789-BIB0040|phy213789-cit-0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/CS20030285","article-title":"Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients","volume":"106","author":"Videla","year":"2004","journal-title":"Clin. Sci."},{"key":"10.14814\/phy2.13789-BIB0041|phy213789-cit-0041","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1210\/en.2008-0262","article-title":"Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity","volume":"149","author":"Weisberg","year":"2008","journal-title":"Endocrinology"},{"key":"10.14814\/phy2.13789-BIB0042|phy213789-cit-0042","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","article-title":"Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States","volume":"148","author":"Wong","year":"2015","journal-title":"Gastroenterology"},{"key":"10.14814\/phy2.13789-BIB0043|phy213789-cit-0043","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1089\/jmf.2007.555","article-title":"Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats","volume":"11","author":"Wu","year":"2008","journal-title":"J. Med. Food"},{"key":"10.14814\/phy2.13789-BIB0044|phy213789-cit-0044","first-page":"277","article-title":"Diet polyphenol curcumin stimulates hepatic Fgf21 production and restores its sensitivity in high-fat-diet-fed male mice","volume":"158","author":"Zeng","year":"2016","journal-title":"Endocrinology"},{"key":"10.14814\/phy2.13789-BIB0045|phy213789-cit-0045","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13789\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:28:03Z","timestamp":1533608883000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":45,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13789","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}