{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:54:17Z","timestamp":1773665657954,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16PRE33410549"],"award-info":[{"award-number":["16PRE33410549"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL113084"],"award-info":[{"award-number":["R01HL113084"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC1HL099538"],"award-info":[{"award-number":["RC1HL099538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.14814\/phy2.13898","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:29:29Z","timestamp":1540258169000},"page":"e13898","source":"Crossref","is-referenced-by-count":16,"title":["Force-frequency relationship and early relaxation kinetics are preserved upon sarcoplasmic blockade in human myocardium"],"prefix":"10.14814","volume":"6","author":[{"given":"Jae-Hoon","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology; The Ohio State University Wexner Medical Center; Columbus Ohio"},{"name":"Dorothy M. Davis Heart and Lung Research Institute; The Ohio State University Wexner Medical Center; Columbus Ohio"},{"name":"Medical Scientist Training Program and Biomedical Sciences Graduate Program; The Ohio State University Wexner Medical Center; Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D.","family":"Canan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology; The Ohio State University Wexner Medical Center; Columbus Ohio"},{"name":"Dorothy M. Davis Heart and Lung Research Institute; The Ohio State University Wexner Medical Center; Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan A.","family":"Whitson","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery; Department of Surgery; The Ohio State University Wexner Medical Center; Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Kilic","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery; Department of Surgery; The Ohio State University Wexner Medical Center; Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M. L.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology; The Ohio State University Wexner Medical Center; Columbus Ohio"},{"name":"Dorothy M. Davis Heart and Lung Research Institute; The Ohio State University Wexner Medical Center; Columbus Ohio"},{"name":"Department of Internal Medicine; The Ohio State University Wexner Medical Center; Columbus Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"key":"10.14814\/phy2.13898-BIB0001|phy213898-cit-0001","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-010-0658-3","volume-title":"Excitation-contraction coupling and cardiac contractile force, in developments in cardiovascular medicine","author":"Bers","year":"2001"},{"key":"10.14814\/phy2.13898-BIB0002|phy213898-cit-0002","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12551-014-0143-5","article-title":"Tri-modal regulation of cardiac muscle relaxation; intracellular calcium decline, thin filament deactivation, and cross-bridge cycling kinetics","volume":"6","author":"Biesiadecki","year":"2014","journal-title":"Biophys Rev"},{"key":"10.14814\/phy2.13898-BIB0003|phy213898-cit-0003","doi-asserted-by":"crossref","first-page":"H249","DOI":"10.1152\/ajpheart.2000.278.1.H249","article-title":"Phospholamban: a major determinant of the cardiac force-frequency relationship","volume":"278","author":"Bluhm","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.13898-BIB0004|phy213898-cit-0004","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jacc.2004.05.049","article-title":"Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart","volume":"44","author":"Chaudhary","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.14814\/phy2.13898-BIB0005|phy213898-cit-0005","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3389\/fphys.2016.00562","article-title":"Myofilament calcium sensitivity: role in regulation of in\u00a0vivo cardiac contraction and relaxation","volume":"7","author":"Chung","year":"2016","journal-title":"Front. Physiol."},{"key":"10.14814\/phy2.13898-BIB0006|phy213898-cit-0006","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yjmcc.2018.07.005","article-title":"Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium","volume":"121","author":"Chung","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.14814\/phy2.13898-BIB0007|phy213898-cit-0007","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/JP275130","article-title":"Ups and downs of calcium in the heart","volume":"596","author":"Eisner","year":"2018","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.13898-BIB0008|phy213898-cit-0008","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.phrs.2016.11.033","article-title":"Effects of zacopride, a moderate IK1 channel agonist, on triggered arrhythmia and contractility in human ventricular myocardium","volume":"115","author":"Elnakish","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.14814\/phy2.13898-BIB0009|phy213898-cit-0009","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1172\/JCI115061","article-title":"Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole","volume":"87","author":"Gwathmey","year":"1991","journal-title":"J Clin Invest"},{"key":"10.14814\/phy2.13898-BIB0010|phy213898-cit-0010","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/01.RES.70.6.1225","article-title":"Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy","volume":"70","author":"Hasenfuss","year":"1992","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13898-BIB0011|phy213898-cit-0011","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.75.3.434","article-title":"Relation between myocardial function and expression of sarcoplasmic reticulum Ca2+-ATPase in failing and nonfailing human myocardium","volume":"75","author":"Hasenfuss","year":"1994a","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13898-BIB0012|phy213898-cit-0012","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/oxfordjournals.eurheartj.a060471","article-title":"Influence of the force-frequency relationship on haemodynamics and left ventricular function in patients with non-failing hearts and in patients with dilated cardiomyopathy","volume":"15","author":"Hasenfuss","year":"1994b","journal-title":"Eur. Heart J."},{"key":"10.14814\/phy2.13898-BIB0013|phy213898-cit-0013","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/hc0202.102238","article-title":"Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium","volume":"105","author":"Hasenfuss","year":"2002","journal-title":"Circulation"},{"issue":"Pt 2","key":"10.14814\/phy2.13898-BIB0014|phy213898-cit-0014","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1469-7793.1998.431bw.x","article-title":"Changes in force and cytosolic Ca2+ concentration after length changes in isolated rat ventricular trabeculae","volume":"506","author":"Kentish","year":"1998","journal-title":"J. Physiol."},{"key":"10.14814\/phy2.13898-BIB0015|phy213898-cit-0015","first-page":"73","article-title":"Changes in intracellular calcium concentration influence beat-to-beat variability of action potential duration in canine ventricular myocytes","volume":"66","author":"Kistamas","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"key":"10.14814\/phy2.13898-BIB0016|phy213898-cit-0016","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/01.RES.0000129181.48395.ff","article-title":"Functional relevance of the stretch-dependent slow force response in failing human myocardium","volume":"94","author":"Lewinski","year":"2004","journal-title":"Circ. Res."},{"issue":"4 Pt 2","key":"10.14814\/phy2.13898-BIB0017|phy213898-cit-0017","first-page":"H1361","article-title":"Effects of left ventricular hypertrophy on force and Ca2+ handling in isolated rat myocardium","volume":"274","author":"Maier","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"3 Pt 2","key":"10.14814\/phy2.13898-BIB0018|phy213898-cit-0018","first-page":"H779","article-title":"Phospholamban-to-SERCA2 ratio controls the force-frequency relationship","volume":"276","author":"Meyer","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.14814\/phy2.13898-BIB0019|phy213898-cit-0019","doi-asserted-by":"crossref","first-page":"H2077","DOI":"10.1152\/ajpheart.00685.2015","article-title":"The Frank-Starling mechanism involves deceleration of cross-bridge kinetics and is preserved in failing human right ventricular myocardium","volume":"309","author":"Milani-Nejad","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.13898-BIB0020|phy213898-cit-0020","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00360-008-0331-3","article-title":"The positive force-frequency relationship is maintained in absence of sarcoplasmic reticulum function in rabbit, but not in rat myocardium","volume":"179","author":"Monasky","year":"2009","journal-title":"J. Comp. Physiol. B."},{"key":"10.14814\/phy2.13898-BIB0021|phy213898-cit-0021","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1172\/JCI118849","article-title":"Diminished post-rest potentiation of contractile force in human dilated\u00a0cardiomyopathy. Functional evidence for alterations\u00a0in intracellular Ca2+ handling","volume":"98","author":"Pieske","year":"1996","journal-title":"J Clin Invest"},{"key":"10.14814\/phy2.13898-BIB0022|phy213898-cit-0022","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.RES.85.1.38","article-title":"Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium","volume":"85","author":"Pieske","year":"1999","journal-title":"Circ. Res."},{"key":"10.14814\/phy2.13898-BIB0023|phy213898-cit-0023","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yjmcc.2003.09.001","article-title":"Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium","volume":"36","author":"Rossman","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.14814\/phy2.13898-BIB0024|phy213898-cit-0024","doi-asserted-by":"crossref","first-page":"e63608","DOI":"10.1371\/journal.pone.0063608","article-title":"The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity","volume":"8","author":"Torres","year":"2013","journal-title":"PLoS ONE"},{"key":"10.14814\/phy2.13898-BIB0025|phy213898-cit-0025","doi-asserted-by":"crossref","first-page":"H2212","DOI":"10.1152\/ajpheart.00778.2006","article-title":"Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity","volume":"292","author":"Varian","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.14814\/phy2.13898-BIB0026|phy213898-cit-0026","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF00408669","article-title":"Decreased expression of cardiac sarcoplasmic reticulum Ca(2\u00a0+\u00a0)-pump ATPase in congestive heart failure due to myocardial infarction","volume":"163-164","author":"Zarain-Herzberg","year":"1996","journal-title":"Mol. Cell. Biochem."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13898\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T01:35:25Z","timestamp":1540863325000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":26,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13898","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}