{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:02:28Z","timestamp":1793325748381,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK115752"],"award-info":[{"award-number":["R01 DK115752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["P30-DK-074038"],"award-info":[{"award-number":["P30-DK-074038"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["R01 DK097423"],"award-info":[{"award-number":["R01 DK097423"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["1-I01-BX002298"],"award-info":[{"award-number":["1-I01-BX002298"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["AMC21"],"award-info":[{"award-number":["AMC21"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Service"},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013793","name":"Polycystic Kidney Disease Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001296","name":"PKD Foundation","doi-asserted-by":"publisher","award":["214g16a"],"award-info":[{"award-number":["214g16a"]}],"id":[{"id":"10.13039\/100001296","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health T32 training grant in Basic Immunology and Immunologic disease","award":["2T32AI007051-38"],"award-info":[{"award-number":["2T32AI007051-38"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.14814\/phy2.13951","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T09:05:07Z","timestamp":1547197507000},"page":"e13951","source":"Crossref","is-referenced-by-count":29,"title":["Urinary T cells correlate with rate of renal function loss in autosomal dominant polycystic kidney disease"],"prefix":"10.14814","volume":"7","author":[{"given":"Kurt A.","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology; The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology; The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Chumley","sequence":"additional","affiliation":[{"name":"Department of Medicine; The University of Alabama at Birmingham; Birmingham Alabama"},{"name":"Nephrology Research and Training Center; The University of Alabama at Birmingham; Birmingham Alabama"},{"name":"Department of Veterans Affairs Medical Center; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Chacana","sequence":"additional","affiliation":[{"name":"Department of Medicine; The University of Alabama at Birmingham; Birmingham Alabama"},{"name":"Nephrology Research and Training Center; The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie E.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology; The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley K.","family":"Yoder","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental and Integrative Biology; The University of Alabama at Birmingham; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Mrug","sequence":"additional","affiliation":[{"name":"Department of Medicine; The University of Alabama at Birmingham; Birmingham Alabama"},{"name":"Nephrology Research and Training Center; The University of Alabama at Birmingham; Birmingham Alabama"},{"name":"Department of Veterans Affairs Medical Center; Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"10.14814\/phy2.13951-BIB0001|phy213951-cit-0001","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ki.2015.71","article-title":"A comparison of ultrasound and magnetic resonance imaging shows that kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease","volume":"88","author":"Bhutani","year":"2015","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13951-BIB0002|phy213951-cit-0002","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1523-1755.2001.00065.x","article-title":"Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats","volume":"60","author":"Cowley","year":"2001","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13951-BIB0003|phy213951-cit-0003","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/art.24136","article-title":"CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients","volume":"60","author":"Enghard","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.14814\/phy2.13951-BIB0004|phy213951-cit-0004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12963-017-0123-7","article-title":"Incidence and survival of end-stage kidney disease due to polycystic kidney disease in Australia and New Zealand (1963-2014)","volume":"15","author":"Fernando","year":"2017","journal-title":"Popul. Health Metr."},{"key":"10.14814\/phy2.13951-BIB0005|phy213951-cit-0005","first-page":"526A","article-title":"Urinary monocyte chemotactic protein-1 (MCP1) predicts progression in autosomal dominant polycystic kidney disease (ADPKD)","volume":"21","author":"Grantham","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13951-BIB0006|phy213951-cit-0006","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1681\/ASN.2011010084","article-title":"Macrophages promote cyst growth in polycystic kidney disease","volume":"22","author":"Karihaloo","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13951-BIB0007|phy213951-cit-0007","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/030098588902600302","article-title":"Hereditary polycystic kidney disease associated with osteorenal syndrome in rats","volume":"26","author":"Kaspareit-Rittinghausen","year":"1989","journal-title":"Vet. Pathol."},{"key":"10.14814\/phy2.13951-BIB0008|phy213951-cit-0008","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.kint.2018.06.025","article-title":"CD8+ T cells modulate autosomal dominant polycystic kidney disease progression","volume":"94","author":"Kleczko","year":"2018","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13951-BIB0009|phy213951-cit-0009","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13075-015-0600-y","article-title":"The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers","volume":"17","author":"Kopetschke","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.14814\/phy2.13951-BIB0010|phy213951-cit-0010","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nm1783","article-title":"A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease","volume":"14","author":"Li","year":"2008","journal-title":"Nat. Med."},{"key":"10.14814\/phy2.13951-BIB0011|phy213951-cit-0011","first-page":"364A","article-title":"Experimental research on the treatment of autosomal dominant polycystic kidney disease with mycophenolate mofetil","volume":"18","author":"Mei","year":"2007","journal-title":"J. Am. Soc. Nehrol."},{"key":"10.14814\/phy2.13951-BIB0012|phy213951-cit-0012","first-page":"59A","article-title":"Prediction of GFR endpoints in early autosomal dominant polycystic kidney disease","volume":"24","author":"Mrug","year":"2013a","journal-title":"Am. J. Nephrol."},{"key":"10.14814\/phy2.13951-BIB0013|phy213951-cit-0013","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/nep.12153","article-title":"Renal macrophages in autosomal recessive polycystic kidney disease","volume":"18","author":"Mrug","year":"2013b","journal-title":"Nephrology"},{"key":"10.14814\/phy2.13951-BIB0014|phy213951-cit-0014","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.14814\/phy2.13951-BIB0015|phy213951-cit-0015","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/ki.2014.120","article-title":"Analysis of data from the ERA-EDTA Registry indicates that conventional treatments for chronic kidney disease do not reduce the need for renal replacement therapy in autosomal dominant polycystic kidney disease","volume":"86","author":"Spithoven","year":"2014","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13951-BIB0016|phy213951-cit-0016","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ki.2012.446","article-title":"Macrophages promote polycystic kidney disease progression","volume":"83","author":"Swenson-Fields","year":"2013","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13951-BIB0017|phy213951-cit-0017","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1681\/ASN.V17980","article-title":"A hereditary model of slowly progressive polycystic kidney disease in the mouse","volume":"1","author":"Takahashi","year":"1991","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13951-BIB0018|phy213951-cit-0018","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1681\/ASN.V10122534","article-title":"Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease","volume":"10","author":"Vogler","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13951-BIB0019|phy213951-cit-0019","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/ki.1992.413","article-title":"Renal histology in polycystic kidney disease with incipient and advanced renal failure","volume":"42","author":"Zeier","year":"1992","journal-title":"Kidney Int."},{"key":"10.14814\/phy2.13951-BIB0020|phy213951-cit-0020","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1097\/01.ASN.0000088720.61783.19","article-title":"Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease","volume":"14","author":"Zheng","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.14814\/phy2.13951-BIB0021|phy213951-cit-0021","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ki.2010.175","article-title":"Renal CD14 expression correlates with the progression of cystic kidney disease","volume":"78","author":"Zhou","year":"2010","journal-title":"Kidney Int."}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.14814%2Fphy2.13951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.14814\/phy2.13951\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T02:58:42Z","timestamp":1662778722000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.14814\/phy2.13951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"URL":"https:\/\/doi.org\/10.14814\/phy2.13951","archive":["Portico"],"relation":{},"ISSN":["2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}