{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:44:31Z","timestamp":1778903071974,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.14814\/phy2.14799","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T12:43:57Z","timestamp":1622119437000},"source":"Crossref","is-referenced-by-count":5,"title":["A collagen extraction and deuterium oxide stable isotope tracer method for the quantification of bone collagen synthesis rates\n            <i>in vivo<\/i>"],"prefix":"10.14814","volume":"9","author":[{"given":"Rita","family":"Civil","sequence":"first","affiliation":[{"name":"Musculoskeletal Physiology Research Group Sport Health and Performance Enhancement Research CentreSchool of Science and TechnologyNottingham Trent University Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Brook","sequence":"additional","affiliation":[{"name":"Clinical, Metabolic and Molecular Physiology University of NottinghamRoyal Derby Hospital Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty J.","family":"Elliott\u2010Sale","sequence":"additional","affiliation":[{"name":"Musculoskeletal Physiology Research Group Sport Health and Performance Enhancement Research CentreSchool of Science and TechnologyNottingham Trent University Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia","family":"Santos","sequence":"additional","affiliation":[{"name":"Musculoskeletal Physiology Research Group Sport Health and Performance Enhancement Research CentreSchool of Science and TechnologyNottingham Trent University Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Varley","sequence":"additional","affiliation":[{"name":"Musculoskeletal Physiology Research Group Sport Health and Performance Enhancement Research CentreSchool of Science and TechnologyNottingham Trent University Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-7590","authenticated-orcid":false,"given":"Sanna","family":"Lensu","sequence":"additional","affiliation":[{"name":"Department of Biology of Physical Activity University of Jyv\u00e4skyl\u00e4 Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Kainulainen","sequence":"additional","affiliation":[{"name":"Department of Biology of Physical Activity University of Jyv\u00e4skyl\u00e4 Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2019-5939","authenticated-orcid":false,"given":"Lauren G.","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology The University of Toledo Toledo OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Britton","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan Ann Arbor MI USA"},{"name":"Department of Molecular and Integrative Physiology University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Clinical, Metabolic and Molecular Physiology University of NottinghamRoyal Derby Hospital Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Smith","sequence":"additional","affiliation":[{"name":"Clinical, Metabolic and Molecular Physiology University of NottinghamRoyal Derby Hospital Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Sale","sequence":"additional","affiliation":[{"name":"Musculoskeletal Physiology Research Group Sport Health and Performance Enhancement Research CentreSchool of Science and TechnologyNottingham Trent University Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-046X","authenticated-orcid":false,"given":"Philip J.","family":"Atherton","sequence":"additional","affiliation":[{"name":"Clinical, Metabolic and Molecular Physiology University of NottinghamRoyal Derby Hospital Derby UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-002-1345-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050201"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.07.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000392"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00815-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2005.12.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-1155-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/JES.0000000000000215"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00580.2004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.02.013"},{"key":"e_1_2_7_12_1","first-page":"114","article-title":"Mechanical basis of bone strength: Influence of bone material, bone structure and muscle action","volume":"17","author":"Hart N. H.","year":"2017","journal-title":"Journal of Musculoskeletal and Neuronal Interactions"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213515190"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-1103-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.02.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.58B4.1018028"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00021.2013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.08.035"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-010-0004-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00983-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00797.2006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093690"},{"key":"e_1_2_7_23_1","first-page":"258A","article-title":"Collagen synthesis in human bone measured using stable isotope\u2010labelled alanine and proline","volume":"52","author":"Scrimgeour C. M.","year":"1993","journal-title":"Proceedings of the Nutrition Society London"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2015.20.1.8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224745"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328285d858"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.08.054"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-2035-9"},{"key":"e_1_2_7_29_1","first-page":"987","article-title":"Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism","volume":"47","author":"Wilkinson D. D. J.","year":"2016","journal-title":"Mass Spectrometry Reviews"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272277"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00650.2013"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20547"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100140410"},{"key":"e_1_2_7_34_1","first-page":"1","article-title":"Effects of loading duration and short rest insertion on cancellous and cortical bone adaptation in the mouse tibia","volume":"12","author":"Yang H.","year":"2017","journal-title":"PLoS One"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.14799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.14799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.14799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T18:49:50Z","timestamp":1622227790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.14814\/phy2.14799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.14814\/phy2.14799"],"URL":"https:\/\/doi.org\/10.14814\/phy2.14799","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}