{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:40:33Z","timestamp":1790404833406,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24EB028941"],"award-info":[{"award-number":["U24EB028941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiol Rep"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.14814\/phy2.14890","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T07:16:48Z","timestamp":1624951008000},"source":"Crossref","is-referenced-by-count":27,"title":["Impact of sodium glucose linked cotransporter\u20102 inhibition on renal microvascular oxygen tension in a rodent model of diabetes mellitus"],"prefix":"10.14814","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-4818","authenticated-orcid":false,"given":"Gregory M. T.","family":"Hare","sequence":"first","affiliation":[{"name":"Department of Anesthesia St. Michael's HospitalUniversity of Toronto Toronto ON Canada"},{"name":"Department of Physiology University of Toronto Toronto ON Canada"},{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia St. Michael's HospitalUniversity of Toronto Toronto ON Canada"},{"name":"Department of Physiology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Thai","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Anesthesia St. Michael's HospitalUniversity of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina P.","family":"Cazorla\u2010Bak","sequence":"additional","affiliation":[{"name":"Department of Anesthesia St. Michael's HospitalUniversity of Toronto Toronto ON Canada"},{"name":"Department of Physiology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Nghiem","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei A.","family":"Vinogradov","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Toronto Toronto ON Canada"},{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"},{"name":"Department of Medicine Division of Cardiology St. Michael's HospitalUniversity of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. David","family":"Mazer","sequence":"additional","affiliation":[{"name":"Department of Anesthesia St. Michael's HospitalUniversity of Toronto Toronto ON Canada"},{"name":"Department of Physiology University of Toronto Toronto ON Canada"},{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"},{"name":"Institute of Medical Science University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program Biomedicine Discovery Institute and Department of Physiology Monash University Melbourne Vic Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge InstituteSt. Michael's Hospital Toronto ON Canada"},{"name":"Department of Medicine Division of Endocrinology St. Michael's HospitalUniversity of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00323.2019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2317-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-019-0105-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51343-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158810"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3180"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01848-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac2022234"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00473.2013"},{"key":"e_1_2_10_11_1","first-page":"42","volume-title":"Brenner and Rector's the kidney","author":"Fenton R.","year":"2016"},{"key":"e_1_2_10_12_1","first-page":"S74","article-title":"Progressive renal disease: The chronic hypoxia hypothesis","volume":"65","author":"Fine L. G.","year":"1998","journal-title":"Kidney International Supplement"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0796"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610422"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.02.041"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1096"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.016"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00206.2006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22229-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.5.629"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.1"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00294.2016"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.051"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030012"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044235"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_2_10_28_1","first-page":"144","volume-title":"Brenner and Rector's the kidney","author":"Mount D. B.","year":"2016"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30256-6"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00689.2014"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1811744"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00324.2003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.604"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5865-1_73"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00425.2014"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00357.2011"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V10122569"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.03.018"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042375"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.016173"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32590-X"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.14890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.14890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.14890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T07:27:34Z","timestamp":1624951654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.14814\/phy2.14890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.14814\/phy2.14890"],"URL":"https:\/\/doi.org\/10.14814\/phy2.14890","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]}}}