{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:50:39Z","timestamp":1791607839599,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006203","name":"Johnson Space Center","doi-asserted-by":"publisher","award":["NNJ15ZSA001N\u2010AGBR"],"award-info":[{"award-number":["NNJ15ZSA001N\u2010AGBR"]}],"id":[{"id":"10.13039\/100006203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.14814\/phy2.14977","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T10:43:53Z","timestamp":1628246633000},"source":"Crossref","is-referenced-by-count":50,"title":["Optic disc edema and chorioretinal folds develop during strict 6\u00b0 head\u2010down tilt bed rest with or without artificial gravity"],"prefix":"10.14814","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-3583","authenticated-orcid":false,"given":"Steven S.","family":"Laurie","sequence":"first","affiliation":[{"name":"KBR Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H.","family":"Greenwald","sequence":"additional","affiliation":[{"name":"KBR Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Marshall\u2010Goebel","sequence":"additional","affiliation":[{"name":"KBR Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura P.","family":"Pardon","sequence":"additional","affiliation":[{"name":"KBR Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Center for Space MedicineBaylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"KBR Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Stern","sequence":"additional","affiliation":[{"name":"Institute of Aerospace MedicineGerman Aerospace CenterClinical Aerospace Medicine Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haleh","family":"Sangi\u2010Haghpeykar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon R.","family":"Macias","sequence":"additional","affiliation":[{"name":"NASA Johnson Space Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Bershad","sequence":"additional","affiliation":[{"name":"Center for Space MedicineBaylor College of Medicine Houston TX USA"},{"name":"Department of Neurology Baylor College of Medicine Houston TX USA"},{"name":"Department of Neurosurgery Baylor College of Medicine Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.10.023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.00910.x"},{"key":"e_1_2_9_4_1","first-page":"568","article-title":"Self\u2010tonometry under microgravity conditions","volume":"66","author":"Draeger J.","year":"1995","journal-title":"Aviation, Space and Environmental Medicine"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00227-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24463"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239228"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01040.2020"},{"key":"e_1_2_9_9_1","first-page":"895","article-title":"Lack of blood\u2010brain barrier properties in microvessels of the prelaminar optic nerve head","volume":"42","author":"Hofman P.","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199509000-00011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279383"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.5261"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.09.042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00250.2020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP273557"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41526-020-0097-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0349"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.0673"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000467"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31829b41a6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz203"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.15011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00863.2020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00885.2016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2017.12.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.6226"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3357\/ASEM.3191.2012"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17459"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.009"},{"key":"e_1_2_9_31_1","unstructured":"Stenger M. B. Tarver W. J. Brunstetter T. Gibson C. R. Laurie S. S. Lee S. M. C. Macias B. R. Mader T. H. Otto C. A. Smith S. M. &Zwart S. R.(2017).NASA Human Research Program Evidence Report: Risk of Spaceflight Associated Neuro\u2010ocular Syndrome (SANS). NASA Johnson Space Center. Available at:https:\/\/humanresearchroadmap.nasa.gov\/evidence\/reports\/SANS.pdf?rnd=0.434276635495143[Accessed April 16 2020]."},{"key":"e_1_2_9_32_1","unstructured":"Sundblad P. Orlov O. Angerer O. Larina I. &Cromwell R.(2014).Guidelines for Standardization of Bed Rest Studies in the Spaceflight Context. International Academy of Astronautics ISBN\/EAN IAA: 9782917761342. Available at.https:\/\/www.nasa.gov\/sites\/default\/files\/atoms\/files\/bed_rest_studies_complete.pdf[Accessed April 16 2020]."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18530"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-015-0037-z"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196926"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/IMCRJ.S86143"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/491894"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2016"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.14977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.14977","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.14977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T11:51:44Z","timestamp":1658836304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.14814\/phy2.14977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":37,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.14814\/phy2.14977"],"URL":"https:\/\/doi.org\/10.14814\/phy2.14977","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}