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The key role of Na<jats:sub>v<\/jats:sub>1.5 in action potential initiation and propagation in both atria and ventricles predisposes organisms lacking <jats:italic>Scn5a<\/jats:italic> or carrying <jats:italic>Scn5a<\/jats:italic> mutations to cardiac arrhythmogenesis. Loss\u2010of\u2010function Na<jats:sub>v<\/jats:sub>1.5 genetic abnormalities account for many cases of the human arrhythmic disorder Brugada syndrome (BrS) and related conduction disorders. A murine model with a heterozygous <jats:italic>Scn5a<\/jats:italic> deletion recapitulates many electrophysiological phenotypes of BrS. This study examines the relationships between its <jats:italic>Scn5a<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> genotype, resulting transcriptional changes, and the consequent phenotypic presentations of BrS. Of 62 selected protein\u2010coding genes related to cardiomyocyte electrophysiological or homeostatic function, concentrations of mRNA transcribed from 15 differed significantly from wild type (WT). Despite halving apparent ventricular <jats:italic>Scn5a<\/jats:italic> transcription heterozygous deletion did not significantly downregulate its atrial expression, raising possibilities of atria\u2010specific feedback mechanisms. Most of the remaining 14 genes whose expression differed significantly between WT and <jats:italic>Scn5a<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> animals involved Ca<jats:sup>2+<\/jats:sup> homeostasis specifically in atrial tissue, with no overlap with any ventricular changes. All statistically significant changes in expression were upregulations in the atria and downregulations in the ventricles. This investigation demonstrates the value of future experiments exploring for and clarifying links between transcriptional control of <jats:italic>Scn5a<\/jats:italic> and of genes whose protein products coordinate Ca<jats:sup>2+<\/jats:sup> regulation and examining their possible roles in BrS.<\/jats:p>","DOI":"10.14814\/phy2.15043","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T13:59:37Z","timestamp":1633787977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Transcriptional profiles of genes related to electrophysiological function in <i>Scn5a<\/i><sup>+\/\u2212<\/sup> murine hearts"],"prefix":"10.14814","volume":"9","author":[{"given":"Michael","family":"Takla","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Science University of Surrey Guildford UK"},{"name":"Christ\u2019s College University of Cambridge Cambridge 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