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The rats were injected with FGF\u201023 or PTH for 5\u00a0h before collecting the duodenum, jejunum, and ileum for Mg<jats:sup>2+<\/jats:sup> transport analysis in Ussing chambers. The duodenum, jejunum, and ileum were directly exposed to FGF\u201023, PTH, or FGF\u201023 plus PTH with or without cell signaling inhibitors for 150\u00a0min in Ussing chambers prior to performing the Mg<jats:sup>2+<\/jats:sup> transport study. The small intestinal tissues were also subjected to western blot analyses for FGF receptor (FGFR), PTH receptor (PTHR), Klotho, transient receptor potential melastatin 6 (TRPM6), and cyclin as well as the cystathionine \u03b2\u2010synthase domain divalent metal cation transport mediator 4 (CNNM4) expression. The small intestine abundantly expressed FGFR and PTHR proteins, whereas, Klotho was not expressed in rat small intestine. Systemic PTH or FGF\u201023 injection significantly suppressed transcellular Mg<jats:sup>2+<\/jats:sup> transport in the duodenum and jejunum. Direct FGF\u201023\u2010, PTH\u2010, or FGF\u201023 plus PTH exposure also suppressed transcellular Mg<jats:sup>2+<\/jats:sup> absorption in the duodenum and jejunum. There was no additional inhibitory effect of PTH and FGF\u201023 on intestinal Mg<jats:sup>2+<\/jats:sup> absorption. The inhibitory effect of PTH, FGF\u201023, or FGF\u201023 plus PTH was abolished by G\u00f6 6850. Systemic PTH\u2010 or FGF\u201023\u2010injection significantly decreased membranous TRPM6 expression, but increased cytosolic CNNM4 expression in the duodenum, jejunum, and ileum. In the present study, we propose a novel magnesiotropic action of PTH and FGF\u201023 by modulating small intestinal Mg<jats:sup>2+<\/jats:sup> absorption.<\/jats:p>","DOI":"10.14814\/phy2.15247","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T10:31:11Z","timestamp":1649241071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fibroblast growth factor\u201023 and parathyroid hormone suppress small intestinal magnesium absorption"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0236-6650","authenticated-orcid":false,"given":"Nasisorn","family":"Suksridechacin","sequence":"first","affiliation":[{"name":"Division of Physiology Department of Biomedical Sciences Faculty of Allied Health Sciences Burapha University  Chonburi Thailand"},{"name":"Biodiversity Research Centre Thailand Institute of Scientific and Technological Research  Pathumthani 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