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Disuse and paralysis from SCI leads to rapid muscle atrophy, with chronic muscle loss likely playing a role in the development of the secondary metabolic disorders often seen in those with SCI. Muscle disuse is associated with mitochondrial dysfunction. Previous evidence has suggested targeting the mitochondria with the tetrapeptide SS\u201031 is beneficial for muscle health in preclinical models that lead to mitochondrial dysfunction, such as cast immobilization or burn injury. We gave young male mice a sham (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) or 65\u00a0kdyne thoracic contusion SCI with (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) or without (<jats:italic>n<\/jats:italic>\u00a0=\u00a09) daily administration of 5.0\u00a0mg\/kg SS\u201031. Hindlimb muscle mass and muscle bundle respiration were measured at 7\u00a0days post\u2010SCI and molecular targets were investigated using immunoblotting, RT\u2010qPCR, and metabolomics. SS\u201031 did not preserve body mass or hindlimb muscle mass 7\u00a0days post\u2010SCI. SS\u201031 had no effect on soleus or plantaris muscle bundle respiration. SCI was associated with elevated levels of protein carbonylation, led to reduced protein expression of activated DRP1 and reductions in markers of mitochondrial fusion. SS\u201031 administration did result in reduced total DRP1 expression, as well as greater expression of inhibited DRP1. Gene expression of proinflammatory cytokines and their receptors were largely stable across groups, although SS\u201031 treatment led to greater mRNA expression of <jats:italic>IL1B<\/jats:italic>, <jats:italic>TNF<\/jats:italic>, and <jats:italic>TNFRSF12A<\/jats:italic>. In summation, SS\u201031 was not an efficacious treatment acutely after a moderate thoracic contusion SCI in young male mice.<\/jats:p>","DOI":"10.14814\/phy2.15266","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T09:47:38Z","timestamp":1653472058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["SS\u201031 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-7025","authenticated-orcid":false,"given":"Zachary A.","family":"Graham","sequence":"first","affiliation":[{"name":"Research Service Birmingham VA Medical Center  Birmingham Alabama USA"},{"name":"Department of Cell, Developmental, and Integrative Biology UAB  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"DeBerry","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine UAB  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Cardozo","sequence":"additional","affiliation":[{"name":"Center for the Medical Consequences of Spinal Cord Injury  Bronx New York USA"},{"name":"Medical Service James J. 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