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This study aimed to further elucidate how this regulatory mechanism is affected during SSM with added resistance (~20% bodyweight). Twenty\u2010five participants (sex\/gender: 13 females\/12 males) completed two bouts of 5\u2010min SSM for both bodyweight and resistance conditions (10% bodyweight in each arm) at frequencies of 0.05\u00a0Hz (20\u2010s squat\/stand cycles) and 0.10\u00a0Hz (10\u2010s squat\/stand cycles). Middle and posterior cerebral artery (MCA\/PCA) cerebral blood velocities were indexed with transcranial Doppler ultrasound. Beat\u2010to\u2010beat blood pressure (BP) was quantified via finger photoplesmography. Transfer function analysis was employed to quantify dCA in both cerebral arteries across the cardiac cycle (diastole, mean, and systole). Two\u2010by\u2010two Analysis of Variance with generalized eta squared effect sizes were utilized to determine differences between resistance vs. bodyweight squats and between sexes\/genders. Absolute mean and diastolic BP were elevated during the resistance squats (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001); however, only the BP point\u2010estimate power spectrum densities were augmented at 0.10\u00a0Hz (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.048). No differences were noted for phase and gain metrics between bodyweight and resistance SSM (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.067); however, females displayed attenuated systolic regulation (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.003). Despite augmented systemic BP during resistance SSM, the brain was effective at buffering the additional stress to mitigate overperfusion\/pressure. Females displayed less dCA regulation within the systolic aspect of the cardiac cycle, which may be associated with physiological underpinnings related to various clinical conditions\/presentations.<\/jats:p>","DOI":"10.14814\/phy2.15278","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T05:01:00Z","timestamp":1652850060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does oscillation size matter? Impact of added resistance on the cerebral pressure\u2010flow Relationship in females and males"],"prefix":"10.14814","volume":"10","author":[{"given":"Kailey T.","family":"Newel","sequence":"first","affiliation":[{"name":"Cerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary  Alberta Canada"},{"name":"Sport Injury Prevention Research Centre Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Integrated Concussion Research Program University of Calgary  Calgary Alberta Canada"},{"name":"Faculty of Health and Exercise Science University of British Columbia  Kelowna British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-5793","authenticated-orcid":false,"given":"Joel S.","family":"Burma","sequence":"additional","affiliation":[{"name":"Cerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary  Alberta Canada"},{"name":"Sport Injury Prevention Research Centre Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Integrated Concussion Research Program University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Carere","sequence":"additional","affiliation":[{"name":"Cerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary  Alberta Canada"},{"name":"Sport Injury Prevention Research Centre Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Integrated Concussion Research Program University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney\u00a0M.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Cerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary  Alberta Canada"},{"name":"Sport Injury Prevention Research Centre Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Integrated Concussion Research Program University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-0038","authenticated-orcid":false,"given":"Jonathan D.","family":"Smirl","sequence":"additional","affiliation":[{"name":"Cerebrovascular Concussion Lab Faculty of Kinesiology University of Calgary  Alberta Canada"},{"name":"Sport Injury Prevention Research Centre Faculty of Kinesiology University of Calgary  Calgary Alberta Canada"},{"name":"Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"},{"name":"Integrated Concussion Research Program University of Calgary  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00854.2014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.036814"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010019\u201000857\u20109"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.540781"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.594168"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256\u2010199826040\u201000002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03192707"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2016.07.002"},{"key":"e_1_2_9_10_1","first-page":"552","article-title":"Non\u2010normal data: Is ANOVA still a valid option?","volume":"29","author":"Blanca M. 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