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The goal of this study, which included both nondiabetic and diabetic rats, was to look at the mechanisms of intermittent fasting and exercise in the management of diabetotoxicity. The effects of starvation and honey on the oral glucose tolerance test, insulin tolerance test, adipocytokines, oxidative glucose metabolic enzymes, glycolytic enzymes, food intake, and body weight in rats with streptozotocin\u2010induced diabetes were also investigated. In the nondiabetic phase, rats were administered an oral regimen of distilled water (0.5\u00a0ml\/rat), honey (1\u00a0g\/kg body weight), and interventions with IF, and starvation for 4\u00a0weeks while in the diabetic phase, after STZ or citrate buffer injections, interventions with IF, exercise, starvation, and honey treatment began for 4\u00a0weeks. At all OGTT and ITT points, there was a substantial rise in glucose in the STZ group. Adipocytokines hormone, oxidative glucose metabolic enzymes, glycolytic enzymes, and body weight were all affected by STZ when compared to starvation and honey, however, IF and exercise significantly reduced these alterations. In diabetic rats, intermittent fasting and exercise enhanced serum adipocytokines levels. These findings imply that adipokines modulate glycolytic\/nonmitochondrial enzymes and glucose metabolic\/mitochondrial dehydrogenase to mediate the antidiabetic effects of intermittent fasting and exercise.<\/jats:p>","DOI":"10.14814\/phy2.15279","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T13:20:38Z","timestamp":1666963238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intermittent fasting and exercise therapy abates STZ\u2010induced diabetotoxicity in rats through modulation of adipocytokines hormone, oxidative glucose metabolic, and glycolytic pathway"],"prefix":"10.14814","volume":"10","author":[{"given":"Ejime A.","family":"Chijiokwu","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eze K.","family":"Nwangwa","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-0770","authenticated-orcid":false,"given":"Mega O.","family":"Oyovwi","sequence":"additional","affiliation":[{"name":"Department of Human Physiology Achievers University  Owo Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander O.","family":"Naiho","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Emojevwe","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Medical Sciences  Ondo Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejiro P.","family":"Ohwin","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosper A.","family":"Ehiwarior","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn T.","family":"Ojugbeli","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udoka S.","family":"Nwabuoku","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onome B.","family":"Oghenetega","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science Babcock University  Ilisan\u2010Romo Ogun State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofulue O.","family":"Ogheneyoma","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Basic Medical Science College of Health Sciences Delta State University  Abraka Delta State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06474"},{"issue":"2","key":"e_1_2_14_3_1","first-page":"53","article-title":"Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats","volume":"41","author":"Ahmed O. 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