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The purpose of this study was to investigate the effects of therapeutic hypothermia on short\u2010term experimental ARDS. Twenty adult female Yorkshire pigs were divided into four groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a05 each): normothermic control (C), normothermic injured (I), hypothermic control (HC), and hypothermic injured (HI). Acute respiratory distress syndrome was induced experimentally via intrapulmonary injection of oleic acid. Target core temperature was achieved in the HI group within 1\u00a0h of injury induction. Cardiorespiratory, histologic, cytokine, and metabolomic data were collected on all animals prior to and following injury\/sham. All data were collected for approximately 12\u00a0h from the beginning of the study until euthanasia. Therapeutic hypothermia reduced injury in the HI compared to the I group (histological injury score\u00a0=\u00a00.51\u00a0\u00b1\u00a00.18 vs. 0.76\u00a0\u00b1\u00a00.06; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.02) with no change in gas exchange. All groups expressed distinct phenotypes, with a reduction in pro\u2010inflammatory metabolites, an increase in anti\u2010inflammatory metabolites, and a reduction in inflammatory cytokines observed in the HI group compared to the I group. Changes to respiratory system mechanics in the injured groups were due to increases in lung elastance (E) and resistance (R) (\u0394E from pre\u2010injury\u00a0=\u00a046\u00a0\u00b1\u00a014\u00a0cmH<jats:sub>2<\/jats:sub>O L<jats:sup>\u22121<\/jats:sup>, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001; \u0394R from pre\u2010injury: 3\u00a0\u00b1\u00a02\u00a0cmH<jats:sub>2<\/jats:sub>O\u00a0L<jats:sup>\u22121<\/jats:sup>\u00a0s<jats:sup>\u2212<\/jats:sup>, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.30) rather than changes to the chest wall (\u0394E from pre\u2010injury: 0.7\u00a0\u00b1\u00a01.6\u00a0cmH<jats:sub>2<\/jats:sub>O\u00a0L<jats:sup>\u22121<\/jats:sup>, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.99; \u0394R from pre\u2010injury: 0.6\u00a0\u00b1\u00a00.1\u00a0cmH<jats:sub>2<\/jats:sub>O\u00a0L<jats:sup>\u22121<\/jats:sup>\u00a0s<jats:sup>\u2212<\/jats:sup>, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.01). Both control groups had no change in respiratory mechanics. In conclusion, therapeutic hypothermia can reduce markers of injury and inflammation associated with experimentally induced short\u2010term ARDS.<\/jats:p>","DOI":"10.14814\/phy2.15286","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T06:45:50Z","timestamp":1651733150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Therapeutic hypothermia attenuates physiologic, histologic, and metabolomic markers of injury in a porcine model of acute respiratory distress syndrome"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0265-254X","authenticated-orcid":false,"given":"Sarah A.","family":"Angus","sequence":"first","affiliation":[{"name":"Department of Kinesiology University of Waterloo  Waterloo Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine Department of Medicine Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad M.","family":"Banoei","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Molgat\u2010Seon","sequence":"additional","affiliation":[{"name":"Department Kinesiology and Applied Health University of Winnipeg  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-9032","authenticated-orcid":false,"given":"Carli M.","family":"Peters","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna R.","family":"Parmar","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald E. G.","family":"Griesdale","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine Department of Medicine Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Anesthesiology Pharmacology &amp; Therapeutics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mypinder","family":"Sekhon","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine Department of Medicine Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-5014","authenticated-orcid":false,"given":"Andrew William","family":"Sheel","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent W.","family":"Winston","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Departments of Medicine and Biochemistry &amp; 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