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However, the effect of short\u2010term food intake change remains to be defined. Here, we investigated the effects of short\u2010term high\u2010fat diet intake and food restriction on cisplatin\u2010induced AKI. Mice were fed either a high\u2010fat diet (HFD) or a low\u2010fat diet (LFD) for 11\u2009days or were not fed for 40\u2009hh (fasting), before cisplatin administration. Cisplatin\u2010induced functional and structural damages to kidneys in both HFD\u2010 and LFD\u2010fed mice, with greater damages in HFD\u2010fed mice than LFD\u2010fed mice. HFD decreased mitochondrial total glutathione (tGSH) level, along with increases in the plasma and kidney cholesterol levels. Cisplatin caused the increase of kidney cholesterol levels and oxidative stress, along with the decrease of mitochondrial tGSH levels. In addition, cisplatin\u2010induced mitochondrial damage and apoptosis of tubular cells in both HFD\u2010 and LFD\u2010fed mice. An increase of Fis1 (mitochondria fission 1 protein), whereas a decrease of Opa1 (mitochondria fusion 1 protein) occurred by cisplatin. These cisplatin effects were greater in HFD\u2010fed mice than in LFD\u2010fed mice. Administration of mitochondria\u2010specific antioxidant treatment during HFD feeding inhibited these cisplatin\u2010induced changes. Fasting for 40\u2009h also significantly reduced the cisplatin\u2010induced changes mentioned above. These data demonstrate that short\u2010term HFD intake worsens cisplatin\u2010induced oxidative stress by the reduction of mitochondrial tGSH, resulting in increased cisplatin\u2010induced nephrotoxicity. These data newly indicate that the control of calorie intake, even for a short period, affects kidney susceptibility to injury. Although most studies described the effects of a long\u2010term high\u2010fat diet on the kidneys, in this study, we found that even if a high\u2010fat diet was consumed for a short\u2010term, physiological changes and mitochondria tGSH decrease in the kidneys, and consequently increased cisplatin\u2010nephrotoxic susceptibility. These data suggest the association of calorie intake with kidney susceptibility to cisplatin.<\/jats:p>","DOI":"10.14814\/phy2.15348","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T07:09:52Z","timestamp":1656054592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Short\u2010term control of diet affects cisplatin\u2010induced acute kidney injury through modulation of mitochondrial dynamics and mitochondrial <scp>GSH<\/scp>"],"prefix":"10.14814","volume":"10","author":[{"given":"Ji Su","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anatomy and BK21 Plus School of Medicine, Kyungpook National University  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Kwon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anatomy and BK21 Plus School of Medicine, Kyungpook National University  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