{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:47:01Z","timestamp":1777733221475,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002733"],"award-info":[{"award-number":["UL1TR002733"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK 068158"],"award-info":[{"award-number":["R01 DK 068158"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Esophageal distal baseline impedance (DBI) is an indicator of mucosal integrity; lower values suggest increased permeability. Aims were to characterize the (1) effect of DBI category (&lt;900\u2009\u03a9, 900\u20132000\u2009\u03a9, and\u2009&gt;2000\u2009\u03a9) on sensory\u2010motor characteristics of mid\u2010esophageal provocation\u2010induced motility reflexes, and (2) clinical outcomes among high\u2010risk human infants evaluated for gastroesophageal reflux disease. Symptomatic infants (<jats:italic>N<\/jats:italic>\u00a0=\u00a049, 41\u2009\u00b1\u20093\u2009weeks postmenstrual age) underwent pH\u2010impedance testing to characterize acid reflux index (ARI) and DBI, and pharyngo\u2010esophageal manometry to examine upper esophageal sphincter (UES), peristaltic, and lower esophageal sphincter (LES) functions. Sensory\u2010motor response characteristics included response threshold (ml), occurrence (%), latency (s), duration (s), and magnitude (mmHg) upon mid\u2010esophageal stimulations (0.1\u20132.0\u2009ml of air, water, and apple juice). Motility and clinical outcomes were compared among DBI groups. In infants with DBI &lt;900\u2009\u03a9 and 900\u20132000\u2009\u03a9 (vs. &gt;2000\u2009\u03a9): (a) Long\u2010term feeding milestones did not differ (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05); (b) complete peristaltic propagation decreased in 900\u20132000\u2009\u03a9 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), polymorphic waveforms increased in &lt;900\u2009\u03a9 and 900\u20132000\u2009\u03a9 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05); (c) media effects were noted with liquids (vs. air) wherein UES and esophageal contractility were prolonged in &lt;900\u2009\u03a9 and 900\u20132000\u2009\u03a9 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and esophageal sensitivity heightened for &lt;900\u2009\u03a9 with water and for 900\u20132000\u2009\u03a9 with air (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). ARI was not correlated with DBI in infants with chronic lung disease (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.05, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.82). We conclude that pharyngo\u2010esophageal motility sensory\u2010motor characteristics in infants are modified by DBI category. These preliminary findings pave\u2010the\u2010way for further physiological testing in convalescing high\u2010risk infants to ascertain potential mechanisms of airway\u2010digestive reflex interactions and symptom generation, which may lead to targeted therapies.<\/jats:p>","DOI":"10.14814\/phy2.15366","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T08:00:44Z","timestamp":1656316844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of esophageal mucosal permeability markers on <scp>provocation\u2010induced<\/scp> esophageal reflexes in <scp>high\u2010risk<\/scp> infants"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9007-8850","authenticated-orcid":false,"given":"Sudarshan R.","family":"Jadcherla","sequence":"first","affiliation":[{"name":"Innovative Infant Feeding Disorders Research Program Nationwide Children's Hospital  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USA"},{"name":"Center for Perinatal Research The Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minna","family":"Njeh","sequence":"additional","affiliation":[{"name":"Innovative Infant Feeding Disorders Research Program Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Center for Perinatal Research The Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas","family":"Alshaikh","sequence":"additional","affiliation":[{"name":"Innovative Infant Feeding Disorders Research Program Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Center for Perinatal Research The Research Institute at Nationwide Children's Hospital  Columbus Ohio 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