{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:41:29Z","timestamp":1773297689988,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the beneficial effects of olive oil against heart failure post\u2010myocardial infarction (PMI), induced by coronary artery ligation in rats. Animals were divided into sham and ligated groups and fed either regular chow, olive oil (10% wt\/wt), or corn oil (10% wt\/wt) and were followed up to 16\u2009weeks. On the echocardiography at 3\u2009days (PMI), in the ligated regular chow (LRC), ligated olive oil (LOO), and ligated corn oil (LCO) left ventricular ejection fraction (LVEF) decrease was 12.14%, 16.42%, and 17.53% from the baseline, respectively. However, only LOO group improved LVEF significantly at 16\u2009weeks PMI and became comparable with all sham groups. Both scar formation and collagen deposition at 16\u2009weeks PMI were less pronounced in the LOO group. Myocardial TNF\u2010\u03b1 level at 4\u2009weeks of PMI increased by 176%, 11%, and 181% in the LRC, LOO, and LCO groups, respectively. Plasma TNF\u2010\u03b1 levels in LOO were significantly lower than LRC group after 4\u2009weeks of PMI. Myocardial redox ratio (reduced glutathione\/oxidized glutathione) decreased at 4\u2009weeks PMI by 44.4%, 16.4%, and 36.9% in the LRC, LOO, and LCO groups, respectively, compared to the baseline. These changes in the redox ratio at 16\u2009weeks PMI were further exacerbated in the LRC and LCO groups. Lipid hydroperoxides formation increased at 4\u2009weeks PMI by 137.4%, 14.6%, and 97.1% in the LRC, LOO, and LCO groups, respectively. Since coronary artery ligation decreased left ventricular ejection fraction, increased myocardial TNF\u2010\u03b1 and oxidative stress, and since olive oil was able to inhibit these effects, it is proposed that dietary olive oil modulates cardiac remodeling and heart failure subsequent to myocardial infarction.<\/jats:p>","DOI":"10.14814\/phy2.15379","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T07:55:17Z","timestamp":1659945317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Olive oil protects against progression of heart failure by inhibiting remodeling of heart subsequent to myocardial infarction in rats"],"prefix":"10.14814","volume":"10","author":[{"given":"Abd Al\u2010Rahman","family":"Al\u2010Shudiefat","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Sciences Faculty of Applied Medical Sciences The Hashemite University  Zarqa Jordan"},{"name":"Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Ludke","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshi","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinder S.","family":"Jassal","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Section of Cardiology, Department of Internal Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashim K.","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Internal Medicine, Cardiology Division University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-9239","authenticated-orcid":false,"given":"Pawan K.","family":"Singal","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010012\u20101447\u2010z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010271"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8575136"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00800.2016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(90)90208\u2010q"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/110.8.1726"},{"key":"e_1_2_8_8_1","first-page":"2986","article-title":"Phase I study of recombinant tumor necrosis factor in cancer patients","volume":"47","author":"Blick M.","year":"1987","journal-title":"Cancer Research"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1976.9999"},{"key":"e_1_2_8_10_1","unstructured":"CDC. (2021).Cardiovascular disease and occupational factors. Retrieved fromhttps:\/\/www.cdc.gov\/niosh\/topics\/heartdisease\/default.html"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2018.07.029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1469281"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.10722"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00919.2007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.101"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800389"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103841.2012.02721.x"},{"key":"e_1_2_8_18_1","unstructured":"FDA. (2017).Monounsaturated fatty acids from olive oil and coronary heart disease. In health claim petition docket no. 2003Q\u20100559; FDA: FDA\u20102017\u2010Q\u20100807."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.110559"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1631560"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.12.036"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/118.4.425"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32203\u20107"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13033291"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108175.2008.00751.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_517_18"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733\u20108651(05)70041\u20102"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.268.2.H517"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010008\u20109104\u2010z"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.005"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(01)01126\u20103"},{"key":"e_1_2_8_32_1","first-page":"90","article-title":"On the mechanism of the positive inotropic action of fluoride, oleate, and calcium on the frog's heart","volume":"114","author":"Loewi O.","year":"1955","journal-title":"The Journal of Pharmacology Experimental Therapeutics"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.17582\/journal.aavs\/2021\/9.10.1684.1691"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061548"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.717033"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130526.20854.fa"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055477"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.8"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.1.H26"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735\u20101097(92)90452\u2010s"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)02690\u20108"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530317666171114114321"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21570"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.115296"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735\u20101097(95)00589\u20107"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.11.1189"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883\u2010001\u20100012\u20100"},{"key":"e_1_2_8_49_1","unstructured":"WHO. (2021).Cardiovascular diseases. Retrieved fromhttps:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cardiovascular\u2010diseases\u2010(cvds)"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.14740\/jem509w"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010019\u201003652\u20102"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.15379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T09:19:05Z","timestamp":1703582345000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":50,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.14814\/phy2.15379"],"URL":"https:\/\/doi.org\/10.14814\/phy2.15379","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"2022-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15379"}}