{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:55:20Z","timestamp":1781272520453,"version":"3.54.1"},"reference-count":74,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.14814\/phy2.15403","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T10:16:39Z","timestamp":1661595399000},"source":"Crossref","is-referenced-by-count":2,"title":["Characterization of the Notch pathway in nasal polyps of patients with chronic rhinosinusitis: A pilot study"],"prefix":"10.14814","volume":"10","author":[{"given":"Giorgio","family":"Aquila","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Alaimo","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Marracino","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Martino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Camponogara","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vieceli Dalla Sega","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fortini","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pannuti","sequence":"additional","affiliation":[{"name":"University of Hawaii Cancer Center, University of Hawaii  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Section of Otolaryngology University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Malagutti","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pelucchi","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7174-9674","authenticated-orcid":false,"given":"Paola","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1199-3"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"35","article-title":"Heart rate reduction with ivabradine in the early phase of atherosclerosis is protective in the endothelium of ApoE\u2010deficient mice","volume":"69","author":"Aquila G.","year":"2018","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-018-0776-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80019-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.025"},{"issue":"5","key":"e_1_2_10_7_1","first-page":"336","article-title":"Immunological profiling of key inflammatory drivers of nasal polyp formation and growth in chronic rhinosinusitis","volume":"57","author":"Biggs T. C.","year":"2019","journal-title":"Rhinology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7582057"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3981"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27237"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.12.1361"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.02.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.027"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.408"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.042"},{"issue":"9","key":"e_1_2_10_17_1","first-page":"654","article-title":"The notch signalling system: Recent insights into the complexity of a conserved pathway. Nature Reviews","volume":"13","author":"Guruharsha K. G.","year":"2012","journal-title":"Genetics"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.09.026"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662264"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1800215"},{"issue":"3","key":"e_1_2_10_21_1","first-page":"227","article-title":"Increased epithelial cell proliferation in nasal polyps","volume":"101","author":"Hsu M. C.","year":"2002","journal-title":"Journal of the Formosan Medical Association"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485890"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43535"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2018.09.029"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2014.12.006"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20187"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2018.06.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-017-0456-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.04.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00095.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1527904"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0030-5"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"55","article-title":"Effects of intranasal budesonide on the expression of c\u2010fos and c\u2010myc in nasal polyps","volume":"22","author":"Lin H.","year":"2008","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.027"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01847.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22214"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-28"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2013.839380"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3210"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015573922"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.067"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.05.005"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino10.261"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S2379"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.783715"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4038"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10125"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.936203"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14046863"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.01.004"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-011-0427-z"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004389"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs141"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/407430"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncoscience.355"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2016.30.4252"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100401"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-016-0250-0"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2017.04.036"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05518.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.171959.111"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2016.01.012"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0715-0"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22250"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.046"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1324"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.034884"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26604"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.041"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.01.079"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.06.006"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1059"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.03.026"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26798"},{"issue":"5","key":"e_1_2_10_75_1","first-page":"2707","article-title":"Inflammatory infiltration and tissue remodeling in nasal polyps and adjacent mucosa of unaffected sinus","volume":"11","author":"Zhu H.","year":"2018","journal-title":"International Journal of Clinical and Experimental Pathology"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.15403","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T08:10:58Z","timestamp":1664784658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":74,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.14814\/phy2.15403"],"URL":"https:\/\/doi.org\/10.14814\/phy2.15403","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8]]}}}