{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:05:16Z","timestamp":1792209916680,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with HFpEF experience severe exercise intolerance due in part to peripheral vascular and skeletal muscle impairments. Interventions targeting peripheral adaptations to exercise training may reverse vascular dysfunction, increase peripheral oxidative capacity, and improve functional capacity in HFpEF. Determine if 8\u2009weeks of isolated knee extension exercise (KE) training will reverse vascular dysfunction, peripheral oxygen utilization, and exercise capacity in patients with HFpEF. Nine HFpEF patients (66\u2009\u00b1\u20095\u2009years, 6 females) performed graded IKE exercise (5, 10, and 15\u2009W) and maximal exercise testing (cycle ergometer) before and after IKE training (3x\/week, 30\u2009min\/leg). Femoral blood flow (ultrasound) and leg vascular conductance (LVC; index of vasodilation) were measured during graded IKE exercise. Peak pulmonary oxygen uptake (V\u0307O<jats:sub>2<\/jats:sub>; Douglas bags) and cardiac output (Q<jats:sub>C<\/jats:sub>; acetylene rebreathe) were measured during graded maximal cycle exercise. IKE training improved LVC (pre: 810\u2009\u00b1\u2009417, post: 1234\u2009\u00b1\u2009347\u00a0ml\/min\/100\u2009mmHg; <jats:italic>p<\/jats:italic>\u00a0=\u20090.01) during 15\u2009W IKE exercise and increased functional capacity by 13% (peak V\u0307O<jats:sub>2<\/jats:sub> during cycle ergometry; pre:12.4\u00a0\u00b1\u20095.2, post: 14.0\u00a0\u00b1\u20096.0\u2009ml\/min\/kg; <jats:italic>p<\/jats:italic>\u00a0=\u20090.01). The improvement in peak V\u0307O<jats:sub>2<\/jats:sub> was independent of changes in Q\u0307c (pre:12.7\u00a0\u00b1\u20093.5, post: 13.2\u00a0\u00b1\u20093.9\u00a0L\/min; <jats:italic>p<\/jats:italic>\u00a0=\u20090.26) and due primarily to increased a\u2010vO<jats:sub>2<\/jats:sub> difference (pre: 10.3\u00a0\u00b1\u20091.6, post: 11.0\u00a0\u00b1\u20091.7; <jats:italic>p<\/jats:italic>\u00a0=\u20090.02). IKE training improved vasodilation and functional capacity in patients with HFpEF. Exercise interventions aimed at increasing peripheral oxidative capacity may be effective therapeutic options for HFpEF patients.<\/jats:p>","DOI":"10.14814\/phy2.15419","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T06:59:34Z","timestamp":1659596374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Isolated knee extensor exercise training improves skeletal muscle vasodilation, blood flow, and functional capacity in patients with <scp>HFpEF<\/scp>"],"prefix":"10.14814","volume":"10","author":[{"suffix":"Jr.","given":"Christopher M.","family":"Hearon","sequence":"first","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel","family":"Samels","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin A.","family":"Dias","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"MacNamara","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas  Dallas Texas USA"},{"name":"University of Texas Southwestern Medical Center Department of Internal Medicine  Dallas Texas 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