{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:58:59Z","timestamp":1793656739903,"version":"4.5.1"},"reference-count":51,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["MLP901"],"award-info":[{"award-number":["MLP901"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008802","name":"Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy","doi-asserted-by":"publisher","award":["GAP0183"],"award-info":[{"award-number":["GAP0183"]}],"id":[{"id":"10.13039\/501100008802","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["MLP901"],"award-info":[{"award-number":["MLP901"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008802","name":"Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy","doi-asserted-by":"publisher","award":["GAP0183"],"award-info":[{"award-number":["GAP0183"]}],"id":[{"id":"10.13039\/501100008802","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"Abstract<\/jats:title>\n \n Autonomic modulation is critical during various physiological activities, including orthostatic stimuli and primarily evaluated by heart rate variability (HRV). Orthostatic stress affects people differently suggesting the possibility of identification of predisposed groups to autonomic dysfunction\u2010related disorders in a healthy state. One way to understand this kind of variability is by using\n Ayurvedic<\/jats:italic>\n approach that classifies healthy individuals into\n Prakriti<\/jats:italic>\n types based on clinical phenotypes. To this end, we explored the differential response to orthostatic stress in different\n Prakriti<\/jats:italic>\n types using HRV. HRV was measured in 379 subjects(\n Vata<\/jats:italic>\n \u00a0=\u00a097,\n Pitta<\/jats:italic>\n \u00a0=\u00a068,\n Kapha<\/jats:italic>\n \u00a0=\u00a068, and Mixed\n Prakriti<\/jats:italic>\n \u00a0=\u00a0146) from two geographical regions(Vadu and Delhi NCR) for 5\u00a0min supine (baseline), 3\u00a0min head\u2010up\u2010tilt (HUT) at 60\u00b0, and 5\u00a0min resupine. We observed that\n Kapha<\/jats:italic>\n group had lower baseline HRV than other two groups, although not statistically significant. The relative change (%\n \u0394<\/jats:italic>\n 1&2<\/jats:sub>\n ) in various HRV parameters in response to HUT was although minimal in\n Kapha<\/jats:italic>\n group.\n Kapha<\/jats:italic>\n also had significantly lower change in HR, LF (nu), HF (nu), and LF\/HF than\n Pitta<\/jats:italic>\n in response to HUT. The relative change (%\n \u0394<\/jats:italic>\n 1<\/jats:sub>\n ) in HR and parasympathetic parameters (RMSSD, HF, SD1) was significantly greater in the\n Vata<\/jats:italic>\n than in the\n Kapha<\/jats:italic>\n . Thus, the low baseline and lower response to HUT in\n Kapha<\/jats:italic>\n and the maximum drop in parasympathetic activity of\n Vata<\/jats:italic>\n may indicate a predisposition to early autonomic dysfunction and associated conditions. It emphasizes the critical role of\n Prakriti<\/jats:italic>\n \u2010based phenotyping in stratifying the differential responses of cardiac autonomic modulation in various postures among healthy individuals across different populations.\n <\/jats:p>","DOI":"10.14814\/phy2.15435","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T03:24:43Z","timestamp":1663212283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Heart rate variability during head\u2010up tilt shows inter\u2010individual differences among healthy individuals of extreme\n Prakriti<\/i>\n types"],"prefix":"10.14814","volume":"10","author":[{"given":"Ritu","family":"Rani","sequence":"first","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"},{"name":"CSIR's Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics) CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Genomics and Molecular Medicine CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"},{"name":"Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathiban","family":"Rengarajan","sequence":"additional","affiliation":[{"name":"Department of Physiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tavpritesh","family":"Sethi","sequence":"additional","affiliation":[{"name":"Genomics and Molecular Medicine CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"},{"name":"Indraprastha Institute of Information Technology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat Krushna","family":"Khuntia","sequence":"additional","affiliation":[{"name":"CSIR's Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics) CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Genomics and Molecular Medicine CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Kumar","sequence":"additional","affiliation":[{"name":"CSIR's Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics) CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Genomics and Molecular Medicine CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deep Shikha","family":"Punera","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"},{"name":"CSIR's Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics) CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Genomics and Molecular Medicine CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"},{"name":"Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Applied Development of Ayurveda Prakriti and Genomics CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"},{"name":"CSIR's Ayurgenomics Unit\u2013TRISUTRA (Translational Research and Innovative Science ThRough Ayurgenomics) CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Genomics and Molecular Medicine CSIR\u2010Institute of Genomics & Integrative Biology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhushan","family":"Girase","sequence":"additional","affiliation":[{"name":"Vadu Rural Health Program KEM Hospital Research Centre Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Vadu Rural Health Program KEM Hospital Research Centre Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Juvekar","sequence":"additional","affiliation":[{"name":"Vadu Rural Health Program KEM Hospital Research Centre Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Pesala","sequence":"additional","affiliation":[{"name":"Indian Institute of Technology Jodhpur Rajasthan 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