{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:54:25Z","timestamp":1771926865909,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM135002"],"award-info":[{"award-number":["P20 GM135002"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preeclampsia (PE) is a hypertensive disorder that impacts 2\u20138% of pregnant women worldwide. It is characterized by new onset hypertension during the second half of gestation and is a leading cause of maternal and fetal morbidity\/mortality. Maternal obesity increases the risk of PE and is a key predictor of childhood obesity and potentially offspring cardiometabolic complications in a sex\u2010dependent manner. The influence of the maternal obesogenic environment, with superimposed PE, on offspring development into adulthood is unknown. Obese BPH\/5 mice spontaneously exhibit late\u2010gestational hypertension, fetal demise and growth restriction, and excessive gestational weight gain. BPH\/5 females have improved pregnancy outcomes when maternal weight loss via pair\u2010feeding is imposed beginning at conception. We hypothesized that phenotypic differences between female and male BPH\/5 offspring can be influenced by pair feeding BPH\/5 dams during pregnancy. BPH\/5 pair\u2010fed dams have improved litter sizes and increased fetal body weights. BPH\/5 offspring born to ad libitum dams have similar sex ratios, body weights, and fecal microbiome as well as increased blood pressure that is reduced in the dam pair\u2010fed offspring. Both BPH\/5 male and female offspring born to pair\u2010fed dams have a reduction in adiposity and an altered gut microbiome, while only female offspring born to pair\u2010fed dams have decreased circulating leptin and white adipose tissue inflammatory cytokines. These sexually dimorphic results suggest that reduction in the maternal obesogenic environment in early pregnancy may play a greater role in female BPH\/5 sex\u2010dependent cardiometabolic outcomes than males. Reprograming females may mitigate the transgenerational progression of cardiometabolic disease.<\/jats:p>","DOI":"10.14814\/phy2.15444","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T09:25:39Z","timestamp":1662456339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sex\u2010specific effects of maternal weight loss on offspring cardiometabolic outcomes in the obese preeclamptic\u2010like mouse model, <scp>BPH<\/scp>\/5"],"prefix":"10.14814","volume":"10","author":[{"given":"Kalie F.","family":"Beckers","sequence":"first","affiliation":[{"name":"Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Southeastern Louisiana University  Hammond Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet P.","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane C.L.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary W.","family":"Childers","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Southeastern Louisiana University  Hammond Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-1243","authenticated-orcid":false,"given":"Jenny L.","family":"Sones","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Sciences, School of Veterinary Medicine Louisiana State University  Baton Rouge Louisiana USA"},{"name":"Pennington Biomedical Research Center Louisiana State University  Baton Rouge Louisiana 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