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The physiological effects of intermittent hypoxia on the respiratory system during spontaneous sleep in individuals with chronic cervical SCI are unknown. We hypothesized that individuals with cervical SCI would demonstrate higher short\u2010 and long\u2010term ventilatory responses to acute intermittent hypoxia (AIH) exposure than individuals with thoracic SCI during sleep. Twenty participants (10 with cervical SCI [9 male] and 10 with thoracic SCI [6 male]) underwent an AIH and sham protocol during sleep. During the AIH protocol, each participant experienced 15 episodes of isocapnic hypoxia using mixed gases of 100% nitrogen (N<jats:sub>2<\/jats:sub>) and 40% carbon dioxide (CO<jats:sub>2<\/jats:sub>) to achieve an oxygen saturation of less than 90%. This was followed by two breaths of 100% oxygen (O<jats:sub>2<\/jats:sub>). Measurements were collected before, during, and 40\u2009min after the AIH protocol to obtain ventilatory data. During the sham protocol, participants breathed room air for the same amount of time that elapsed during the AIH protocol and at approximately the same time of night. Hypoxic ventilatory response (HVR) during the AIH protocol was significantly higher in participants with cervical SCI than those with thoracic SCI. There was no significant difference in minute ventilation (<jats:italic>V<\/jats:italic><jats:sub>.E.<\/jats:sub>), tidal volume (<jats:italic>V<\/jats:italic><jats:sub>.T.<\/jats:sub>), or respiratory frequency (<jats:italic>f<\/jats:italic>) during the recovery period after AIH in cervical SCI compared to thoracic SCI groups. Individuals with cervical SCI demonstrated a significant short\u2010term increase in HVR compared to thoracic SCI. However, there was no evidence of ventilatory long\u2010term facilitation following AIH in either group.<\/jats:p>","DOI":"10.14814\/phy2.15455","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T09:25:20Z","timestamp":1662456320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tetraplegia is associated with increased hypoxic ventilatory response during nonrapid eye movement sleep"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-4526","authenticated-orcid":false,"given":"Sarah","family":"Vaughan","sequence":"first","affiliation":[{"name":"Department of Medicine John D. Dingell VA Medical Center  Detroit Michigan USA"},{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-3375","authenticated-orcid":false,"given":"Abdulghani","family":"Sankari","sequence":"additional","affiliation":[{"name":"Department of Medicine John D. Dingell VA Medical Center  Detroit Michigan USA"},{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"},{"name":"Department of Medical Education Ascension Providence Hospital  Southfield Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Medicine John D. Dingell VA Medical Center  Detroit Michigan USA"},{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Eshraghi","sequence":"additional","affiliation":[{"name":"Department of Medicine John D. Dingell VA Medical Center  Detroit Michigan USA"},{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Obiakor","sequence":"additional","affiliation":[{"name":"Department of Medicine John D. Dingell VA Medical Center  Detroit Michigan USA"},{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Yarandi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susmita","family":"Chowdhuri","sequence":"additional","affiliation":[{"name":"Department of Medicine John D. Dingell VA Medical Center  Detroit Michigan USA"},{"name":"Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anan","family":"Salloum","sequence":"additional","affiliation":[{"name":"Department of Medicine John D. 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