{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:11:44Z","timestamp":1753884704759,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001275","name":"Oak Foundation","doi-asserted-by":"publisher","award":["Ocay\u201013\u2010309"],"award-info":[{"award-number":["Ocay\u201013\u2010309"]}],"id":[{"id":"10.13039\/100001275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bioimpedance (mfBIA) non\u2010invasively assesses cellular muscle health. Our aim was to explore whether mfBIA captures abnormal cellular muscle health in patients with Parkinson's Disease (PD) and how such changes are modulated with the use of Parkinson's medication. In patients with PD (<jats:italic>n<\/jats:italic>\u00a0=\u200920) mfBIA measurements were made of biceps brachii, triceps, and extensor carpi radialis longus muscles of the more affected arm whilst at rest, using a mobile mfBIA device (IMPEDIMED, Australia). mfBIA and assessment of motor symptoms were performed in a pragmatic off\u2010medication state, as well as one and 3\u2009h after oral intake of 200\u2009mg levodopa. Age and sex\u2010matched healthy subjects (HC; <jats:italic>n<\/jats:italic>\u00a0=\u200920) served as controls. PD and HC mfBIA parameters were compared by applying an unpaired two\u2010tailed adjusted <jats:italic>t<\/jats:italic>\u2010test and ANOVA with Tukey's correction for multiple comparisons (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.05). The PD group consisted of 13 men (71\u2009\u00b1\u200917\u2009years) and 7 women (65\u2009\u00b1\u20097\u2009years). Independent of medication, internal (R<jats:sub>i<\/jats:sub>) and external resistance (R<jats:sub>e<\/jats:sub>) were found to be significantly higher, and membrane capacitance (Mc) significantly lower, in <jats:italic>m.biceps brachii<\/jats:italic> in PD subjects compared to HC. Center frequency (fc) was significantly higher in <jats:italic>m.biceps brachii<\/jats:italic> of PD subjects in the \u201cmedication\u2010off\u201d state. There was no difference between PD and HC in mfBIA parameters in the measured extensor muscles. The upper limb flexor muscle shows a difference in mfBIA parameters in PD compared to HC. mfBIA may be useful in the diagnosis and assessment of PD patients and is objective, non\u2010invasive, reliable, and easy to use.<\/jats:p>","DOI":"10.14814\/phy2.15465","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T06:44:16Z","timestamp":1665038656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Probing cellular health at the muscle level\u2014Multi\u2010frequency bioimpedance in Parkinson's disease"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0603-1142","authenticated-orcid":false,"given":"Marko","family":"Celicanin","sequence":"first","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6495-5629","authenticated-orcid":false,"given":"Adrian Paul","family":"Harrison","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Copenhagen, IVH, PAS (Excitable Tissues &amp; Biomechanics)  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack Kvistgaard","family":"Olsen","sequence":"additional","affiliation":[{"name":"The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Korbo","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemette","family":"L\u00f8kkegaard","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Bjerg","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Danneskiold\u2010Sams\u00f8e","sequence":"additional","affiliation":[{"name":"The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartwig Roman","family":"Siebner","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen, IVH, PAS (Excitable Tissues &amp; Biomechanics)  Copenhagen Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research Copenhagen University Hospital Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tihomir","family":"Ilic","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Medical Faculty of Military Medical Academy University of Defense  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-9678","authenticated-orcid":false,"given":"Else Marie","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22609"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12354"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12022"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181a9ed9b"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013\u20104694(95)93574\u2010q"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.10.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X132488"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531\u20108257(200001)15:1<48::aid\u2010mds1009>3.0.co;2\u2010e"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20213"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/36\/3\/453"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.12.061"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019629"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/34\/2\/237"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/36\/1\/27"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21481"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns1001s49"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318230208a"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2022.10463"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27461"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.13059"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/29\/2\/003"},{"key":"e_1_2_11_26_1","first-page":"757","article-title":"Bioelectric impedance analysis of lower leg ischaemic muscles","volume":"1","author":"Tonkovic S.","year":"2000","journal-title":"IEEE Conf. 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