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Characteristic of the infection is the compromising of taste and smell. There is a persistent need to discriminate the dysfunctions and correlation between taste and smell, which are probably epiphenomena of other concealed conditions. Anosmic and ageusic long\u2010term <jats:styled-content style=\"fixed-case\">COVID<\/jats:styled-content>\u201019 patients were re\u2010evaluated after 1\u2009year using a Volabolomic approach with an e\u2010nose recording system coupled with olfactometric and gustometric tests. Here a range of sensory arrangements was found, from normal taste and smell to complete losses. The following patterns of olfactory threshold (OT)\u2010taste threshold\u2010olfactory uni\u2010 and cross\u2010modal perception were found anosmia\u2010severe hypogeusia\u2010anosmia; hyposmia\u2010hypogeusia\u2010severe hyposmia; normosmia\u2010ageusia\u2010hyposmia; severe hyposmia \u2010normogeusia\u2010normosmia. There is a strong correlation between OT and olfactory uni\u2010 and cross\u2010modal perception, a moderate correlation between olfactory and taste threshold and no correlation between OT and taste threshold. In conclusion, this study provides evidence for the feasibility of testing the chemical senses to directly objectify function in order to discriminate taste from olfactory impairment. Furthermore, it allows to hypothesize a long\u2010term effect of the virus due to neuroinvasion through, probably, the olfactory system with injury in the related multisensory areas of taste and smell.<\/jats:p>","DOI":"10.14814\/phy2.15486","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T08:14:30Z","timestamp":1669104870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physiological discrimination and correlation between olfactory and gustatory dysfunction in long\u2010term <scp>COVID<\/scp>\u201019"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-0029","authenticated-orcid":false,"given":"Andrea","family":"Mazzatenta","sequence":"first","affiliation":[{"name":"Neuroscience, Imaging and Clinical Sciences Department \u2018G. d'Annunzio\u2019 Chieti\u2010Pescara University  Chieti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420932617"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"427","article-title":"Smell and taste disorders: A primary care approach","volume":"61","author":"Bromley S. 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