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We tested RREPs evoked by brief airway occlusions in 10 participants with moderate\u2010to\u2010severe COPD, 11 age\u2010matched controls (AMC) and 14 young controls (YC), with similar airway occlusion pressure stimuli across groups. Mean age was 76\u2009years for COPD and AMC groups, and 30\u2009years for the YC group. Occlusion intensity and unpleasantness was rated using the modified Borg scale, and anxiety rated using the Hospital Anxiety and Depression Scale. There was no difference in RREP peak amplitudes across groups, except for the N1 peak, which was significantly greater in the YC group than the COPD and AMC groups (<jats:italic>p<\/jats:italic>\u00a0=\u20090.011). The latencies of P1, P2 and P3 occurred later in COPD versus YC (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05). P3 latency occurred later in AMC than YC (<jats:italic>p<\/jats:italic>\u00a0=\u20090.024). COPD and AMC groups had similar Borg ratings for occlusion intensity (3.0 (0.5, 3.5) [Median (IQR)] and 3.0 (3.0, 3.0), respectively; <jats:italic>p<\/jats:italic>\u00a0=\u20090.476) and occlusion unpleasantness (1.3 (0.1, 3.4) and 1.0 (0.75, 2.0), respectively; <jats:italic>p<\/jats:italic>\u00a0=\u20090.702). The COPD group had a higher anxiety score than AMC group (<jats:italic>p<\/jats:italic>\u00a0=\u20090.013). A higher N1 amplitude suggests the YC group had higher cognitive processing of respiratory inputs than the COPD and AMC groups. Both COPD and AMC groups showed delayed neural responses to the airway occlusion, which may indicate impaired processing of respiratory sensory inputs in COPD and healthy aging.<\/jats:p>","DOI":"10.14814\/phy2.15519","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T06:55:50Z","timestamp":1670050550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Respiratory\u2010related evoked potentials in chronic obstructive pulmonary disease and healthy aging"],"prefix":"10.14814","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9003-3188","authenticated-orcid":false,"given":"Isabella","family":"Epiu","sequence":"first","affiliation":[{"name":"Neuroscience Research Australia  Randwick New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"Prince of Wales Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Gandevia","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Randwick New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"Prince of Wales Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire L.","family":"Boswell\u2010Ruys","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Randwick New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"},{"name":"Prince of Wales Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie G.","family":"Carter","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Randwick New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison T.","family":"Finn","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Randwick New South Wales Australia"},{"name":"University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A. 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