{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:04:41Z","timestamp":1792123481506,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The brown bear\n                    <jats:italic>Ursus arctos<\/jats:italic>\n                    undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.\n                  <\/jats:p>","DOI":"10.14814\/phy2.15550","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:26:01Z","timestamp":1672791961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Translational implications of bradyarrhythmia in hibernating brown bears"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-4275","authenticated-orcid":false,"given":"Lisa A.","family":"Gottlieb","sequence":"first","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Bispebjerg  Copenhagen Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina L.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Forestry and Wildlife Management Inland Norway University of Applied Sciences  Koppang Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Forestry and Wildlife Management Inland Norway University of Applied Sciences  Koppang Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Fr\u00f6bert","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Pharmacology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bj\u00f6rkenheim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2015.4.1.28"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12983"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-46.3.724"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.173"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000090685.13169.07"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57126-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01787-4"},{"key":"e_1_2_10_9_1","first-page":"486","article-title":"Management of sinus node dysfunction with junctional escape rhythm in a case of anorexia nervosa","volume":"38","author":"Kossaify A.","year":"2010","journal-title":"Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir"},{"key":"e_1_2_10_10_1","first-page":"e382","article-title":"2018 ACC\/AHA\/HRS guideline on the evaluation and Management of Patients with Bradycardia and Cardiac Conduction Delay: A report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society","volume":"140","author":"Kusumoto F. 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