{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:24:11Z","timestamp":1787235851189,"version":"build-2736575974"},"reference-count":91,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Left ventricular mechanical dyssynchrony (LVMD) refers to the nonuniformity in mechanical contraction and relaxation timing in different ventricular segments. We aimed to determine the relationship between LVMD and LV performance, as assessed by ventriculo\u2010arterial coupling (VAC), LV mechanical efficiency (LV\n                    <jats:sub>eff<\/jats:sub>\n                    ), left ventricular ejection fraction (LVEF), and diastolic function during sequential experimental changes in loading and contractile conditions. Thirteen Yorkshire pigs submitted to three consecutive stages with two opposite interventions each: changes in afterload (phenylephrine\/nitroprusside), preload (bleeding\/reinfusion and fluid bolus), and contractility (esmolol\/dobutamine). LV pressure\u2013volume data were obtained with a conductance catheter. Segmental mechanical dyssynchrony was assessed by global, systolic, and diastolic dyssynchrony (DYS) and internal flow fraction (IFF). Late systolic LVMD was related to an impaired VAC, LV\n                    <jats:sub>eff<\/jats:sub>\n                    , and LVEF, whereas diastolic LVMD was associated with delayed LV relaxation (logistic tau), decreased LV peak filling rate, and increased atrial contribution to LV filling. The hemodynamic factors related to LVMD were contractility, afterload, and heart rate. However, the relationship between these factors differed throughout the cardiac cycle. LVMD plays a significant role in LV systolic and diastolic performance and is associated with hemodynamic factors and intraventricular conduction.\n                  <\/jats:p>","DOI":"10.14814\/phy2.15607","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T20:59:32Z","timestamp":1676667572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between intraventricular mechanical dyssynchrony and left ventricular systolic and diastolic performance: An in vivo experimental study"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-2114","authenticated-orcid":false,"given":"Manuel Ignacio","family":"Monge\u00a0Garc\u00eda","sequence":"first","affiliation":[{"name":"Intensive Care Unit Hospital Universitario SAS Jerez  Jerez de la Frontera Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Jian","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras","family":"Hatib","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J.","family":"Settles","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cecconi","sequence":"additional","affiliation":[{"name":"Department Anaesthesia and Intensive Care Units, Humanitas Research Hospital Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Pinsky","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"H883","article-title":"Wall motion asynchrony prolongs time constant of left ventricular relaxation","volume":"257","author":"Aoyagi T.","year":"1989","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90671-X"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2009.01962.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.2.483"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.5.812"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.02.009"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.038"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.02.058"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1983.244.3.H417"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.082"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90166-0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80315-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01987-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80387-X"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.1.190"},{"key":"e_1_2_12_17_1","first-page":"H428","article-title":"Influence of pacing site on canine left ventricular contraction","volume":"251","author":"Burkhoff D.","year":"1986","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.250.6.R1021"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.01.024"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90600.2008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.074"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743120"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.11.005"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.264.6.H1817"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.3.H1053"},{"key":"e_1_2_12_26_1","first-page":"H2516","article-title":"Force\u2010frequency relations during heart failure in pigs","volume":"267","author":"Eising G. 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