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Thus, the objective of this study was to evaluate the effects of food readjustment and\/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet\u2010induced obesity. Forty C57BL\/6J ovariectomized mice were divided into the following groups: high\u2010fat diet\u2010fed \u2010 60% lipids throughout the protocol (HF), food readjustment \u2010 60% lipids for 5\u2009weeks, readjusted to 10% for the next 5\u2009weeks (FR), high\u2010fat diet\u2010fed undergoing moderate\u2010intensity exercise training (HFT), and food readjustment associated with moderate\u2010intensity exercise training (FRT). Blood glucose evaluations and oral glucose tolerance tests were performed. Blood pressure was assessed by direct intra\u2010arterial measurement. Baroreflex sensitivity was tested using heart rate phenylephrine and sodium nitroprusside induced blood pressure changes. Cardiovascular autonomic modulation was evaluated in time and frequency domains. Inflammatory profile was evaluated by IL\u20106, IL\u201010 cytokines, and TNF\u2010alpha measurements. Only the exercise training associated with food readjustment strategy induced improved functional capacity, body composition, metabolic parameters, inflammatory profile, and resting bradycardia, while positively changing cardiovascular autonomic modulation and increasing baroreflex sensitivity. Our findings demonstrate that the association of these strategies seems to be effective in the management of cardiometabolic risk in a model of loss of ovarian function with diet\u2010induced obesity.<\/jats:p>","DOI":"10.14814\/phy2.15609","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T01:23:51Z","timestamp":1678497831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Food readjustment plus exercise training improves cardiovascular autonomic control and baroreflex sensitivity in high\u2010fat diet\u2010fed ovariectomized mice"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0283-7432","authenticated-orcid":false,"given":"Bruno","family":"Nascimento\u2010Carvalho","sequence":"first","affiliation":[{"name":"Unidade de Hipertensao, Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina Universidade de Sao Paulo (InCor\u2010HCFMUSP)  S\u00e3o Paulo Brazil"},{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Dos\u2010Santos","sequence":"additional","affiliation":[{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Da\u00a0Costa\u2010Santos","sequence":"additional","affiliation":[{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina L.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar A.","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Unidade de Hipertensao, Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina Universidade de Sao Paulo (InCor\u2010HCFMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila P.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3640-9049","authenticated-orcid":false,"given":"Katia","family":"De\u00a0Angelis","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erico C.","family":"Caperuto","sequence":"additional","affiliation":[{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u2010Claudia","family":"Irigoyen","sequence":"additional","affiliation":[{"name":"Unidade de Hipertensao, Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina Universidade de Sao Paulo (InCor\u2010HCFMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia\u00a0B.","family":"Scapini","sequence":"additional","affiliation":[{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris C.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Human Movement Lab S\u00e3o Judas Tadeu University (USJT)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.163147"},{"key":"e_1_2_8_3_1","first-page":"104","article-title":"Efeitos do treinamento aer\u00f3bico sobre a freq\u00fc\u00eancia card\u00edaca","volume":"9","author":"Almeida M. 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