{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:21Z","timestamp":1787022381564,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["M449"],"award-info":[{"award-number":["M449"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal obesity is associated with increased risk of prolonged and dysfunctional labor and emergency caesarean section. To elucidate the mechanisms behind the associated uterine dystocia, a translational animal model is required. Our previous work identified that exposure to a high\u2010fat, high\u2010cholesterol (HFHC) diet to induce obesity down\u2010regulates uterine contractile associated protein expression and causes asynchronous contractions ex vivo. This study aims to investigate the impact of maternal obesity on uterine contractile function in vivo using intrauterine telemetry surgery. Virgin female Wistar rats were fed either a control (CON,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06) or HFHC (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06) diet for 6\u2009weeks prior to conception, and throughout pregnancy. On Day 9 of gestation, a pressure\u2010sensitive catheter was surgically implanted aseptically within the gravid uterus. Following 5\u2009days recovery, intrauterine pressure (IUP) was recorded continuously until delivery of the 5th pup (Day 22). HFHC induced obesity led to a significant 1.5\u2010fold increase in IUP (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.026) and fivefold increase in frequency of contractions (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.013) relative to CON. Determination of the time of labor onset identified that HFHC rats IUP (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.046) increased significantly 8\u00a0h prior to 5th pup delivery, which contrasts to CON with no significant increase. Myometrial contractile frequency in HFHC rats significantly increased 12\u2009h prior to delivery of the 5th pup (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.023) compared to only 3\u00a0h in CON, providing evidence that labor in HFHC rats was prolonged by 9\u00a0h. In conclusion, we have established a translational rat model that will allow us to unravel the mechanism behind uterine dystocia associated with maternal obesity.\n                  <\/jats:p>","DOI":"10.14814\/phy2.15610","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T20:30:32Z","timestamp":1677789032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of maternal obesity on in vivo uterine contractile activity during parturition in the rat"],"prefix":"10.14814","volume":"11","author":[{"given":"Ronan","family":"Muir","sequence":"first","affiliation":[{"name":"Division of Food Nutrition and Dietetics, School of Bioscience University of Nottingham, Sutton Bonington Campus  Loughborough England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raheela","family":"Khan","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine University of Nottingham, Royal Derby Hospital  Derby England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly","family":"Shmygol","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Medicine and Health Sciences United Arab Emirates University  Al Ain UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Quenby","sequence":"additional","affiliation":[{"name":"Biomedical Research Unit in Reproductive Health University Hospital Coventry and Warwickshire  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-080X","authenticated-orcid":false,"given":"Matthew","family":"Elmes","sequence":"additional","affiliation":[{"name":"Division of Food Nutrition and Dietetics, School of Bioscience University of Nottingham, Sutton Bonington Campus  Loughborough England UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2012.12.013"},{"key":"e_1_2_11_3_1","first-page":"225","article-title":"Intrauterine pressure during the second stage of labour in obese women","volume":"103","author":"Buhimschi C.","year":"2004","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_11_4_1","unstructured":"Butland B. 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