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It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. We report a case of an elderly male presenting with significant recurrent hyponatremia,\u00a0and prerenal azotemia. With recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium, he was diagnosed to have cisplatin induced renal salt wasting syndrome.<\/jats:p>","DOI":"10.14814\/phy2.15617","type":"journal-article","created":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T01:18:03Z","timestamp":1677892683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Profound hyponatremia and dehydration: A case of cisplatin induced renal salt wasting syndrome"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1275-2723","authenticated-orcid":false,"given":"Tissa Bijoy","family":"George","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, UPMC McKeesport  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Kuriakose","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, UPMC Mercy  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjana Chandrasekhara","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, UPMC McKeesport  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Powell","sequence":"additional","affiliation":[{"name":"PINE Nephrology, UPMC McKeesport  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-5415","authenticated-orcid":false,"given":"Thomas R.","family":"Kleyman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Department of Cell Biology, Department of Pharmacology and Chemical Biology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"48","article-title":"Cisplatin\u2010induced acute hyponatremia leading to a seizure and coma: a case report","volume":"34","author":"Cheng C. 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