{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:36:33Z","timestamp":1784741793053,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/03083\u20104"],"award-info":[{"award-number":["2013\/03083\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37 DK35254"],"award-info":[{"award-number":["R37 DK35254"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We tested the hypothesis that third ventricular (3V) injections of angiotensin 1\u20137 (Ang 1\u20137) increases thermogenesis in brown adipose tissue (BAT), and whether the Mas receptor mediates this response. First, in male Siberian hamsters (<jats:italic>n<\/jats:italic>\u00a0=\u200918), we evaluated the effect of Ang 1\u20137 in the interscapular BAT (IBAT) temperature and, using selective Mas receptor antagonist A\u2010779, the role of Mas receptor in this response. Each animal received 3V injections (200\u2009nL), with 48\u2009h intervals: saline; Ang 1\u20137 (0.03, 0.3, 3, and 30\u2009nmol); A\u2010779 (3\u00a0nmol); and Ang 1\u20137 (0.3\u00a0nmol)\u2009+\u2009A\u2010779 (3\u00a0nmol). IBAT temperature increased after 0.3\u00a0nmol Ang 1\u20137 compared with Ang 1\u20137\u00a0+\u2009A\u2010779 at 20, 30, and 60\u2009min. Also, 0.3\u00a0nmol Ang 1\u20137 increased IBAT temperature at 10 and 20\u2009min, and decreased at 60\u2009min compared with pretreatment. IBAT temperature decreased after A\u2010779 at 60\u2009min and after Ang 1\u20137\u00a0+\u2009A\u2010779 at 30 and 60\u2009min compared with the respective pretreatment. A\u2010779 and Ang 1\u20137\u00a0+\u2009A\u2010779 decreased core temperature at 60\u2009min compared with 10\u00a0min. Then, we evaluated blood and tissue Ang 1\u20137 levels, and the expression of hormone\u2010sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) in IBAT. Male Siberian hamsters (<jats:italic>n<\/jats:italic>\u00a0=\u200936) were killed 10\u00a0min after one of the injections. No changes were observed in blood glucose, serum and IBAT Ang 1\u20137 levels, and ATGL. Ang 1\u20137 (0.3\u00a0nmol) increased p\u2010HSL expression compared with A\u2010779 and increased p\u2010HSL\/HSL ration compared with other injections. Ang 1\u20137 and Mas receptor immunoreactive cells were found in brain regions that coincide with the sympathetic nerves outflow to BAT. In conclusion, 3V injection of Ang 1\u20137 induced thermogenesis in IBAT in a Mas receptor\u2010dependent manner.<\/jats:p>","DOI":"10.14814\/phy2.15621","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T06:34:50Z","timestamp":1678516490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Central angiotensin 1\u20137 triggers brown fat thermogenesis"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-6923","authenticated-orcid":false,"given":"F. S.","family":"Evangelista","sequence":"first","affiliation":[{"name":"School of Arts, Science and Humanities University of Sao Paulo  Sao Paulo Brazil"},{"name":"Department of Biology, Center for Obesity Reversal, Neuroscience Institute Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Bartness","sequence":"additional","affiliation":[{"name":"Department of Biology, Center for Obesity Reversal, Neuroscience Institute Georgia State University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90103-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2005.07.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.1.R291"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.276.6.R1569"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72266"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2014.05.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.10.2475"},{"key":"e_1_2_9_9_1","first-page":"1","article-title":"The brain and brown fat","volume":"10","author":"Contreras C.","year":"2014","journal-title":"Annals of medicine"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00284.2003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00426.2009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.27.061406.093734"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009433"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00310.2020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048966"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3891"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02423-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-266247"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.05.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0348-z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117758"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00192.2017"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2012.04.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.03.006"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1432869100"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094759"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00535.2009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000179216.04357.49"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700047-JLR200"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05723.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67803"}],"container-title":["Physiological Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15621","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.14814\/phy2.15621","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.14814\/phy2.15621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T08:34:02Z","timestamp":1703579642000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.14814\/phy2.15621"],"URL":"https:\/\/doi.org\/10.14814\/phy2.15621","archive":["Portico"],"relation":{},"ISSN":["2051-817X","2051-817X"],"issn-type":[{"value":"2051-817X","type":"print"},{"value":"2051-817X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15621"}}