{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:03:06Z","timestamp":1785780186858,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous research has shown that \u226460\u2009min hypoxic exposure improves subsequent glycaemic control, but the optimal level of hypoxia is unknown and data are lacking from individuals with overweight. We undertook a cross\u2010over pilot feasibility study investigating the effect of 60\u2010min prior resting exposure to different inspired oxygen fractions (CON F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub>\u00a0=\u00a00.209; HIGH F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub>\u00a0=\u00a00.155; VHIGH F<jats:sub>I<\/jats:sub>O<jats:sub>2<\/jats:sub>\u00a0=\u00a00.125) on glycaemic control, insulin sensitivity, and oxidative stress during a subsequent oral glucose tolerance test (OGTT) in males with overweight (mean (SD) BMI\u00a0=\u00a027.6 (1.3) kg\/m<jats:sup>2<\/jats:sup>; <jats:italic>n<\/jats:italic>\u00a0=\u00a012). Feasibility was defined by exceeding predefined withdrawal criteria for peripheral blood oxygen saturation (SpO<jats:sub>2<\/jats:sub>), partial pressure of end\u2010tidal oxygen or carbon dioxide and acute mountain sickness (AMS), and dyspnoea symptomology. Hypoxia reduced SpO<jats:sub>2<\/jats:sub> in a stepwise manner (CON\u00a0=\u00a097(1)%; HIGH\u00a0=\u00a091(1)%; VHIGH\u00a0=\u00a081(3)%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but did not affect peak plasma glucose concentration (CON\u00a0=\u00a07.5(1.8) mmol\u2219L<jats:sup>\u22121<\/jats:sup>; HIGH\u00a0=\u00a07.7(1.1) mmol\u2219L<jats:sup>\u22121<\/jats:sup>; VHIGH\u00a0=\u00a07.7(1.1) mmol\u2219L<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.777; <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.013), plasma glucose area under the curve, insulin sensitivity, or metabolic clearance rate of glucose (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). We observed no between\u2010conditions differences in oxidative stress (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05), but dyspnoea and AMS symptoms increased in VHIGH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), with one participant meeting the withdrawal criteria. Acute HIGH or VHIGH exposure prior to an OGTT does not influence glucose homeostasis in males with overweight, but VHIGH is associated with adverse symptomology and reduced feasibility.<\/jats:p>","DOI":"10.14814\/phy2.15623","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T09:50:01Z","timestamp":1683280201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of different levels of acute hypoxia on subsequent oral glucose tolerance in males with overweight: A balanced cross\u2010over pilot feasibility study"],"prefix":"10.14814","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-6471","authenticated-orcid":false,"given":"Jo","family":"Corbett","sequence":"first","affiliation":[{"name":"Extreme Environments Laboratory, School of Sport, Health and Exercise Science University of Portsmouth  Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Tipton","sequence":"additional","affiliation":[{"name":"Extreme Environments Laboratory, School of Sport, Health and Exercise Science University of Portsmouth  Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Perissiou","sequence":"additional","affiliation":[{"name":"Clinical, Health and Rehabilitation Team, School of Sport, Health and Exercise Science University of Portsmouth  Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"James","sequence":"additional","affiliation":[{"name":"Extreme Environments Laboratory, School of Sport, Health and Exercise Science University of Portsmouth  Portsmouth UK"},{"name":"Clinical, Health and Rehabilitation Team, School of Sport, Health and Exercise Science University of Portsmouth  Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Young","sequence":"additional","affiliation":[{"name":"National Horizons Centre Teesside University  Middlesbrough UK"},{"name":"School of Health and Life Sciences Teesside University  Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Newman","sequence":"additional","affiliation":[{"name":"National Horizons Centre Teesside University  Middlesbrough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cummings","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrinology Department Portsmouth Hospitals University NHS Trust  Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Centre for Sport Exercise and Health, Dept Medicine University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-7581","authenticated-orcid":false,"given":"Michael P. 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