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Turmeric (<jats:italic>Curcuma longa<\/jats:italic>) is a polyphenolic and biologically active natural compound with various pharmacological functions. The aim of this systematic review was to determine the efficacy of curcumin supplementation for reducing RD severity. This review complied with the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) statement. A comprehensive literature search was conducted in Cochrane library, PubMed, Scopus, Web of Science, and MEDLINE databases. A total of seven studies comprising 473 cases and 552 controls were included in this review. Four studies demonstrated that curcumin supplementation had a beneficial effect on RD intensity. These data provide evidence for the potential clinical use of curcumin in supportive cancer care. Further large prospective and well\u2010designed trials are warranted to exactly determine the \u201creal effective extract, supplemental form and dose of curcumin\u201d for RD prevention and treatment of patients receiving radiotherapy.<\/jats:p>","DOI":"10.14814\/phy2.15624","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T07:30:50Z","timestamp":1678087850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic effect of turmeric on radiodermatitis: A systematic review"],"prefix":"10.14814","volume":"11","author":[{"given":"Atieh","family":"Ostadi","sequence":"first","affiliation":[{"name":"Faculty of Paramedical, Mashhad Branch Islamic Azad University  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Arab\u2010Zozani","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Birjand University of Medical Sciences  Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Zarei","sequence":"additional","affiliation":[{"name":"Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Brighton &amp; Sussex Medical School Division of Medical Education  Falmer UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4563-6112","authenticated-orcid":false,"given":"Afsane","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit Imam Reza Hospital, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Clinical Research Development Unit of Akbar Hospital Faculty of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"90","article-title":"Evaluation of anti\u2010inflammatory effects of curcumin gel as an adjunct to scaling and root planing: A clinical study","volume":"7","author":"Anuradha B.","year":"2015","journal-title":"Journal of International Oral Health\u00e5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12890"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-167-7_10"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14584"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90083-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00483.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80971-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199708000-00013"},{"key":"e_1_2_10_12_1","first-page":"151","article-title":"Chemopreventive effects of \u03b1\u2010santalol on skin tumor development in CD\u20101 and SENCAR mice","volume":"12","author":"Dwivedi C.","year":"2003","journal-title":"Cancer Epidemiology and Prevention Biomarkers"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000178075.20124.2a"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0788-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.8.2117S"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"Ginex P. 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