{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:52:37Z","timestamp":1779277957124,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T00:00:00Z","timestamp":1679788800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["grant number 183774"],"award-info":[{"award-number":["grant number 183774"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Loss of the mediator Of cell motility 1 (<jats:italic>Memo1<\/jats:italic>) in mice caused kidney disease and a bone disease with diminished osteoblast and osteoclast biomarkers in serum, resembling alterations occurring in adynamic bone disease in humans with chronic kidney disease or in Klotho\u2010deficient mice. Here, we investigated whether <jats:italic>Memo1<\/jats:italic> expression in osteoblasts is required for normal bone structure and FGF23 expression. We deleted <jats:italic>Memo1<\/jats:italic> in the osteoblast\u2013osteocyte lineage in Memo fl\/fl mice using a Cre under Col1a1 promotor to obtain osteoblast\u2010specific knockout (obKO) mice. We studied organs by micro\u2010computed tomography, qPCR, and western blot. We challenged mice with folic acid for acute kidney injury (AKI) and analyzed organs. Memo obKO were viable without changes in gross anatomy, serum electrolytes, or circulating FGF23 concentrations compared to controls. <jats:italic>Memo1<\/jats:italic> expression was blunted in bones of Memo obKO, whereas it remained unchanged in other organs. Micro\u2010CT revealed no differences between genotypes in bone structure of vertebrae, femur, and tibia. During AKI, <jats:italic>Fgf23<\/jats:italic> expression in calvaria, and renal transcriptional changes were comparable between genotypes. However, renal injury marker expression, circulating FGF23, and parathyroid hormone revealed a sex difference with more severely affected females than males of either genotype. The present data imply that Memo1 in osteoblasts is dispensable for bone structure and expression of <jats:italic>Fgf23<\/jats:italic>. Moreover, we found evidence of potential sex differences in murine folic acid nephropathy similar to other experimental models of renal injury that are important to consider when using this experimental model of renal injury.<\/jats:p>","DOI":"10.14814\/phy2.15650","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:28:21Z","timestamp":1679884101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>FGFR<\/scp> regulator Memo1 is dispensable for <scp>FGF23<\/scp> expression by osteoblasts during folic acid\u2010driven kidney injury"],"prefix":"10.14814","volume":"11","author":[{"given":"Katalin","family":"Bartos","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension Bern University Hospital  Bern Switzerland"},{"name":"Department of Biomedical Research University of Bern  Bern Switzerland"},{"name":"National Center of Competence in Research (NCCR) Kidney Control of Homeostasis (Kidney.CH), University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-651X","authenticated-orcid":false,"given":"Matthias B.","family":"Moor","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Bern University Hospital  Bern Switzerland"},{"name":"Department of Biomedical Research University of Bern  Bern Switzerland"},{"name":"National Center of Competence in Research (NCCR) Kidney Control of Homeostasis (Kidney.CH), University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000665\u2010x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010022\u201000710\u20101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021081150"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.02.026"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01494"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-228320"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00332.2015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00590.2012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601036R"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5705"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094114"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/36285"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-021-00373-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004870"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1134"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14410"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00874"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10034"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-352"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0937-y"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11111316"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419081"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-04701-x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.740615"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2015.12.024"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ame2.12194"}],"container-title":["Physiological 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