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However, the precise signaling pathways leading to the exaggerated autonomic responses in PAD are undetermined. Considering that limb ischemia\/reperfusion (I\/R) is a feature of PAD, we determined the characteristics of acid\u2010sensing ion channel (ASIC) currents in muscle dorsal root ganglion (DRG) neurons under the conditions of hindlimb I\/R and ischemia of PAD. In particular, we examined ASIC currents in two distinct subpopulations, isolectin B<jats:sub>4<\/jats:sub>\u2010positive, and B<jats:sub>4<\/jats:sub>\u2010negative (IB4+ and IB4\u2212) muscle DRG neurons, linking to glial cell line\u2010derived neurotrophic factor and nerve growth factor. In results, ASIC1a\u2010 and ASIC3\u2010like currents were observed in IB4\u2212 muscle DRG neurons with a greater percentage of ASIC3\u2010like currents. Hindimb I\/R and ischemia did not alter the distribution of ASIC1a and ASIC3 currents with activation of pH\u00a06.7 in IB4+ and IB4\u2212 muscle DRG neurons; however, I\/R altered the distribution of ASIC3 currents in IB4+ muscle DRG neurons with pH\u00a05.5, but not in IB4\u2212 neurons. In addition, I\/R and ischemia amplified the density of ASIC3\u2010like currents in IB4\u2212 muscle DRG neurons. Our results suggest that a selective subpopulation of muscle afferent nerves should be taken into consideration when ASIC signaling pathways are studied to determine the exercise pressor reflex in PAD.<\/jats:p>","DOI":"10.14814\/phy2.15654","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T03:20:25Z","timestamp":1679887225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics of acid\u2010sensing ion channel currents in male rat muscle dorsal root ganglion neurons following ischemia\/reperfusion"],"prefix":"10.14814","volume":"11","author":[{"given":"Qin","family":"Li","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute The Pennsylvania State University College of Medicine  Hershey Pennsylvania 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