{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:06:22Z","timestamp":1787022382106,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011076","name":"Simon Fougner Hartmanns Familiefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["physoc.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Physiological Reports"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The purpose of this study was to investigate the effects of loading conditions and left ventricular (LV) contractility on mitral annular dynamics. In 10 anesthetized pigs, eight piezoelectric transducers were implanted equidistantly around the mitral annulus. High\u2010fidelity catheters measured left ventricular pressures and the slope of the end\u2010systolic pressure\u2010volume relationship (\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>es<\/jats:sub>\n                    ) determined LV contractility. Adjustments of pre\u2010 and afterload were done by constriction of the inferior caval vein and occlusion of the descending aorta. Mitral annulus area indexed to body surface area (MAA\n                    <jats:sub>i<\/jats:sub>\n                    ), annular circularity index (ACI), and non\u2010planarity angle (NPA) were calculated by computational analysis. MAA\n                    <jats:sub>i<\/jats:sub>\n                    was more dynamic in response to loading interventions than ACI and NPA. However, MAA\n                    <jats:sub>i<\/jats:sub>\n                    maximal cyclical reduction (\u2212\u0394r) and average deformational velocity (\u2212) did not change accordingly (\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.31 and\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.22). Reduced\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>es<\/jats:sub>\n                    was associated to attenuation in MAA\n                    <jats:sub>i<\/jats:sub>\n                    \u2010\u0394r and MAA\n                    <jats:sub>i<\/jats:sub>\n                    \u2010 (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.744;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001 and\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.467;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029). In conclusion, increased cardiac load and reduced LV contractility may cause deterioration of mitral annular dynamics, likely impairing coaptation and increasing susceptibility to valvular incompetence.\n                  <\/jats:p>","DOI":"10.14814\/phy2.15665","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T21:14:46Z","timestamp":1681679686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mitral annular dynamics are influenced by left ventricular load and contractility in an acute animal model"],"prefix":"10.14814","volume":"11","author":[{"given":"Robert Matongo","family":"Persson","sequence":"first","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Science, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Martin Dahl","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Department of Structural Engineering, Faculty of Engineering Science The Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-7688","authenticated-orcid":false,"given":"John\u2010Peder Escobar","family":"Kvitting","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketil","family":"Grong","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorien Emile","family":"Prot","sequence":"additional","affiliation":[{"name":"Department of Structural Engineering, Faculty of Engineering Science The Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo\u2010Riitta","family":"Salminen","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e5rd","family":"Svenheim","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Leiknes","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lodve","family":"Stangeland","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Haaverstad","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Science, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-8870","authenticated-orcid":false,"given":"Stig","family":"Urheim","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"},{"name":"Department of Clinical Science, Faculty of Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025260"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.1.106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02937-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00208.2007"},{"key":"e_1_2_10_7_1","volume-title":"Carpentier's reconstructive valve surgery: From valve analysis to valve reconstruction","author":"Carpentier A. 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